47325

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 597020..597498 Replicon chromosome
Accession NZ_CP008740
Organism Haemophilus influenzae 2019

Toxin (Protein)


Gene name VapD Uniprot ID A0A0H3PEZ5
Locus tag C645_RS03100 Protein ID WP_005656500.1
Coordinates 597020..597298 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID A0A0M1GIA6
Locus tag C645_RS03105 Protein ID WP_005649350.1
Coordinates 597307..597498 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C645_RS03080 592211..593881 - 1671 WP_005688724.1 fructose-specific PTS transporter subunit EIIC -
C645_RS03085 593883..594824 - 942 WP_005688722.1 1-phosphofructokinase -
C645_RS03090 594826..596325 - 1500 WP_005656498.1 fused PTS fructose transporter subunit IIA/HPr protein -
C645_RS03095 596397..596927 - 531 WP_005656499.1 hypothetical protein -
C645_RS03100 597020..597298 - 279 WP_005656500.1 virulence-associated protein VapD Toxin
C645_RS03105 597307..597498 - 192 WP_005649350.1 DUF5397 domain-containing protein Antitoxin
C645_RS03110 597570..598868 - 1299 WP_032821894.1 hemolysin family protein -
C645_RS03115 598919..599443 - 525 WP_005656502.1 DUF1523 family protein -
C645_RS03120 599470..600252 - 783 WP_005659775.1 YchF/TatD family DNA exonuclease -
C645_RS03125 600307..601290 - 984 WP_005659773.1 DNA polymerase III subunit delta' -
C645_RS03130 601287..601919 - 633 WP_005656505.1 dTMP kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin

Protein of unknown function DUF5397

(1-63)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.09 Da        Isoelectric Point: 5.7408

>T47325 WP_005656500.1 NZ_CP008740:c597298-597020 [Haemophilus influenzae 2019]
MYAIAFDLVVKDTQDYHPKGVQQAYTDIGAVLAKFGFVRTQGSLYTNMNEDMANLFQAMNALKQLAWISQSVRDIRAFRI
EQWSDFTDFIRN

Download         Length: 279 bp

>T47325 NZ_CP008740:c597298-597020 [Haemophilus influenzae 2019]
ATGTACGCGATTGCTTTTGATTTAGTTGTAAAAGACACTCAAGATTATCATCCAAAGGGTGTTCAACAGGCTTATACAGA
CATTGGCGCAGTTTTAGCAAAATTTGGTTTTGTTAGAACACAAGGAAGTTTATATACCAATATGAATGAAGATATGGCGA
ATCTCTTTCAGGCAATGAATGCACTAAAACAGTTGGCGTGGATTTCTCAGTCTGTACGAGATATTCGCGCTTTTCGTATT
GAGCAATGGTCTGATTTTACTGATTTTATACGAAATTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7047.02 Da        Isoelectric Point: 3.9930

>AT47325 WP_005649350.1 NZ_CP008740:c597498-597307 [Haemophilus influenzae 2019]
MELRQQIPTGCIKQFGQFGVPYVVGEVAEFLPDGDVLVNITLLQSGEKDIYRLSHLLEDPEAE

Download         Length: 192 bp

>AT47325 NZ_CP008740:c597498-597307 [Haemophilus influenzae 2019]
ATGGAACTAAGACAACAAATTCCAACAGGCTGTATTAAGCAATTTGGGCAATTTGGCGTGCCTTATGTGGTTGGCGAGGT
TGCGGAATTTTTGCCAGATGGTGATGTGTTGGTGAATATCACATTGTTACAATCTGGTGAAAAAGACATTTATCGCTTAT
CTCACCTGCTTGAAGATCCCGAAGCTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3PEZ5

Antitoxin

Source ID Structure
AlphaFold DB A0A0M1GIA6

References