Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 428913..429550 Replicon chromosome
Accession NZ_CP008740
Organism Haemophilus influenzae 2019

Toxin (Protein)


Gene name VapC1 Uniprot ID A0A0Y7JDC3
Locus tag C645_RS02125 Protein ID WP_005659980.1
Coordinates 429146..429550 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID A0A0H3PN67
Locus tag C645_RS02120 Protein ID WP_005656316.1
Coordinates 428913..429149 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C645_RS02095 424141..424881 - 741 WP_005649034.1 YebC/PmpR family DNA-binding transcriptional regulator -
C645_RS02100 425041..425517 - 477 WP_005656312.1 dihydroneopterin triphosphate diphosphatase -
C645_RS02105 425539..427305 - 1767 WP_005656313.1 aspartate--tRNA ligase -
C645_RS02110 427524..428042 + 519 WP_005656314.1 isoprenylcysteine carboxyl methyltransferase family protein -
C645_RS02115 428095..428820 + 726 WP_005656315.1 carboxy-S-adenosyl-L-methionine synthase CmoA -
C645_RS02120 428913..429149 + 237 WP_005656316.1 antitoxin Antitoxin
C645_RS02125 429146..429550 + 405 WP_005659980.1 type II toxin-antitoxin system VapC family toxin Toxin
C645_RS02130 429616..430023 + 408 WP_005656318.1 lactoylglutathione lyase -
C645_RS02135 430097..430786 + 690 WP_005659978.1 ribonuclease T -
C645_RS02140 431100..432452 + 1353 WP_046067579.1 Na+/H+ antiporter family protein -
C645_RS02145 432485..433072 + 588 WP_046067580.1 primosomal replication protein -
C645_RS02155 433428..433994 - 567 WP_005635150.1 elongation factor P -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin

SpoVT-AbrB domain

(6-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15660.23 Da        Isoelectric Point: 8.9777

>T47324 WP_005659980.1 NZ_CP008740:429146-429550 [Haemophilus influenzae 2019]
MIYMLDTNIIIYLMKNRPKIVAERVSQLLPNDRLVISFITYAELIKGAFGSQNYEQSIRAIELLTERVNVLYPNEQICLH
YGKWANTLKKQGRPIGNNDLWIACHALSLNAVLITHNVKEFQRITDLQWQDWTK

Download         Length: 405 bp

>T47324 NZ_CP008740:429146-429550 [Haemophilus influenzae 2019]
ATGATTTATATGTTAGACACCAATATCATTATTTATTTAATGAAAAATCGCCCCAAAATTGTTGCCGAACGAGTATCACA
ATTATTGCCTAATGATCGCTTAGTTATCAGCTTTATTACTTATGCTGAACTTATTAAAGGCGCCTTTGGTAGTCAAAATT
ATGAGCAATCAATACGAGCAATAGAATTACTTACTGAACGAGTAAATGTACTATATCCCAATGAACAAATCTGTTTACAT
TATGGCAAATGGGCAAATACACTCAAAAAACAAGGGAGACCTATCGGAAATAATGATCTATGGATTGCTTGTCACGCATT
GAGTTTAAATGCTGTTCTTATTACACATAATGTAAAAGAATTTCAGCGTATTACAGATCTTCAGTGGCAAGATTGGACAA
AATAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9007.16 Da        Isoelectric Point: 4.2342

>AT47324 WP_005656316.1 NZ_CP008740:428913-429149 [Haemophilus influenzae 2019]
MLAKVFQSGNSQAVRIPMDFRFDVDTVEIFRKENGDVVLRPVSKKTDDFLALFEGFDETFIQALEARDDLPPQERENL

Download         Length: 237 bp

>AT47324 NZ_CP008740:428913-429149 [Haemophilus influenzae 2019]
ATGCTTGCTAAAGTGTTTCAAAGTGGTAACAGCCAAGCTGTTCGGATCCCGATGGACTTTCGTTTTGACGTCGATACCGT
AGAAATTTTCCGAAAGGAAAATGGGGATGTGGTATTACGCCCAGTTTCTAAAAAAACAGATGATTTTCTTGCGTTATTTG
AAGGATTTGATGAGACCTTTATTCAAGCACTTGAAGCGCGTGATGATTTACCGCCTCAGGAGCGAGAAAATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Y7JDC3

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3PN67

References