Detailed information of TA system TA047315

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/Tad-HTH_37
• Location: 2833118..2833818
• Replicon: chromosome
• Accession: NZ_CP008730
• Organism: Burkholderia multivorans strain DDS 15A-1

Toxin (Protein)

• Gene name: tad
• Uniprot ID: A0A2S9M997
• Locus tag: DM80_RS28955
• Protein ID: WP_035951940.1
• Coordinates: 2833441..2833818 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: -
• Locus tag: DM80_RS28950
• Protein ID: WP_006413467.1
• Coordinates: 2833118..2833441 (-)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DM80_RS28930	2828466..2829926	+	1461	WP_048805885.1	PLP-dependent aminotransferase family protein	-
DM80_RS28935	2830086..2831984	+	1899	WP_048805886.1	molecular chaperone HtpG	-
DM80_RS28940	2831993..2832607	+	615	WP_012212956.1	chorismate lyase	-
DM80_RS28945	2832604..2833095	+	492	WP_048805887.1	DNA-deoxyinosine glycosylase	-
DM80_RS28950	2833118..2833441	-	324	WP_006413467.1	helix-turn-helix domain-containing protein	Antitoxin
DM80_RS28955	2833441..2833818	-	378	WP_035951940.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DM80_RS36405	2834109..2834246	-	138	WP_155772743.1	hypothetical protein	-
DM80_RS28960	2834348..2834602	-	255	WP_048805888.1	hypothetical protein	-
DM80_RS28965	2834830..2835747	+	918	WP_048805889.1	spermidine synthase	-
DM80_RS28970	2835944..2836177	+	234	WP_006398697.1	DUF3311 domain-containing protein	-
DM80_RS28975	2836174..2837724	+	1551	WP_006398698.1	sodium:solute symporter family protein	-
DM80_RS28980	2837828..2838277	-	450	WP_006413500.1	VOC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (23-114)

Antitoxin

• Cro/C1-type helix-turn-helix domain (30-85)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13604.61 Da
• Isoelectric Point: 9.5844

>T47315 WP_035951940.1 NZ_CP008730:c2833818-2833441 [Burkholderia multivorans]
MGINSSMVPYTKPLYWLGSARRDLKAMPEAVQDTFGYALYLAQTGGKHDQAKPLRGFGSAGVLEVVESEDSGTYRAVYTV
KLGGAVYVLHCFQKKSCRGIATPKPDIELVRARLRAAEAHANGEK

Nucleotide

• Length: 378 bp

>T47315 NZ_CP008730:c2833818-2833441 [Burkholderia multivorans]
ATGGGTATAAATTCGTCGATGGTTCCATACACTAAACCGCTTTACTGGCTCGGCTCGGCACGCAGGGACTTGAAAGCGAT
GCCCGAAGCGGTACAGGACACGTTTGGCTATGCGCTGTATCTGGCTCAGACGGGAGGAAAGCACGATCAGGCCAAGCCGT
TGAGGGGCTTCGGATCGGCCGGCGTGCTCGAGGTCGTGGAGTCGGAGGACAGCGGCACGTACCGGGCGGTCTATACGGTG
AAACTCGGTGGCGCCGTCTATGTGCTGCACTGTTTCCAGAAGAAATCGTGCCGCGGTATCGCTACACCGAAGCCGGACAT
CGAACTGGTTCGCGCGCGCCTGAGGGCCGCCGAAGCACACGCAAATGGAGAAAAGTGA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 11828.75 Da
• Isoelectric Point: 8.0686

>AT47315 WP_006413467.1 NZ_CP008730:c2833441-2833118 [Burkholderia multivorans]
MIEIERGSGNVYADLGMPDAEEMRVKAQLAAKIAEIIKTRKWTQQHAARLLGMTQPKLSNMLRGQFRGVSEAKMLDCLAK
LGRDVQIVVGPDRHSEAEGHIEVVFAA

Nucleotide

• Length: 324 bp

>AT47315 NZ_CP008730:c2833441-2833118 [Burkholderia multivorans]
ATGATCGAAATCGAACGGGGCAGCGGCAACGTCTACGCGGATCTGGGCATGCCCGACGCCGAAGAAATGCGCGTCAAGGC
TCAACTCGCGGCCAAGATCGCGGAGATCATCAAGACCCGCAAATGGACGCAGCAGCACGCGGCGCGGTTGCTCGGCATGA
CGCAACCGAAGCTATCGAATATGCTGCGCGGGCAGTTTCGCGGCGTAAGCGAAGCGAAGATGCTCGACTGTCTCGCCAAG
CTCGGGCGCGATGTCCAGATCGTCGTAGGACCGGACCGTCATTCGGAAGCCGAAGGACACATCGAAGTCGTATTCGCTGC
CTGA

Structures

Toxin

• AlphaFold DB: A0A2S9M997