Detailed information of TA system TA047314

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapC-vagC/VapC-VagC
• Location: 1684629..1685266
• Replicon: chromosome
• Accession: NZ_CP008730
• Organism: Burkholderia multivorans strain DDS 15A-1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: DM80_RS23625
• Protein ID: WP_048805442.1
• Coordinates: 1684629..1685030 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: -
• Locus tag: DM80_RS23630
• Protein ID: WP_048805443.1
• Coordinates: 1685030..1685266 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DM80_RS23615	1681960..1683102	+	1143	WP_006401424.1	alginate lyase family protein	-
DM80_RS23620	1683129..1684517	+	1389	WP_006401425.1	L-serine ammonia-lyase	-
DM80_RS23625	1684629..1685030	-	402	WP_048805442.1	type II toxin-antitoxin system VapC family toxin	Toxin
DM80_RS23630	1685030..1685266	-	237	WP_048805443.1	AbrB family transcriptional regulator	Antitoxin
DM80_RS23635	1685454..1687157	+	1704	WP_048805444.1	thiamine pyrophosphate-binding protein	-
DM80_RS23640	1687154..1688251	+	1098	WP_048805445.1	ADP-heptose--LPS heptosyltransferase	-
DM80_RS23650	1688379..1689410	-	1032	WP_048805447.1	helix-turn-helix domain-containing protein	-
DM80_RS23655	1689574..1690116	-	543	WP_048805448.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-119)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14965.10 Da
• Isoelectric Point: 5.2054

>T47314 WP_048805442.1 NZ_CP008730:c1685030-1684629 [Burkholderia multivorans]
MPRYMLDTNMCIYLMKNQPEQVARRFAQCYTGDVVMSAITYAELEYGVTVCANPARERRNLAALIEDIPVAPFDGAAAQA
YGPIREATRERKKDHLDKLIGAHAVSLDVVLVTNNERDFAGYPGLRLENWLTD

Nucleotide

• Length: 402 bp

>T47314 NZ_CP008730:c1685030-1684629 [Burkholderia multivorans]
ATGCCGCGCTACATGCTCGACACCAACATGTGCATCTATCTGATGAAGAACCAGCCGGAGCAGGTCGCGCGGCGTTTCGC
GCAGTGCTACACGGGGGACGTCGTCATGTCGGCGATCACCTATGCGGAACTCGAGTACGGCGTGACGGTATGTGCCAATC
CGGCGCGCGAACGCCGCAATCTCGCCGCGCTGATCGAGGATATCCCGGTTGCGCCGTTCGACGGAGCGGCTGCGCAGGCA
TACGGCCCCATTCGCGAGGCGACGCGCGAACGCAAGAAGGATCATCTCGACAAGCTGATCGGCGCGCACGCGGTATCGCT
CGACGTCGTGCTGGTGACCAACAACGAGCGTGATTTCGCGGGTTATCCGGGCTTGAGGCTCGAGAACTGGCTGACCGACT
AG

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8985.09 Da
• Isoelectric Point: 5.1651

>AT47314 WP_048805443.1 NZ_CP008730:c1685266-1685030 [Burkholderia multivorans]
MHITRVFRNGNSQAVRIPADLAYERSDIELEIERVGDEIRIRPARRPLTGVLGKFAKFGPDFMAEGRGDQEQAEREDW

Nucleotide

• Length: 237 bp

>AT47314 NZ_CP008730:c1685266-1685030 [Burkholderia multivorans]
ATGCATATCACCCGGGTCTTCCGGAATGGCAACTCGCAGGCGGTGCGGATTCCTGCGGATCTGGCTTATGAGCGCAGCGA
TATCGAACTCGAAATCGAGCGTGTCGGTGATGAAATTCGCATCCGGCCTGCGCGGCGGCCGCTGACCGGCGTGCTCGGCA
AGTTCGCGAAATTCGGGCCGGATTTCATGGCCGAGGGGCGCGGCGATCAGGAACAGGCCGAGCGCGAGGATTGGTGA