Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 1595729..1596285 Replicon chromosome
Accession NZ_CP008730
Organism Burkholderia multivorans strain DDS 15A-1

Toxin (Protein)


Gene name parE Uniprot ID A0A8A8D2I2
Locus tag DM80_RS23210 Protein ID WP_034188048.1
Coordinates 1595995..1596285 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A8A8D2B6
Locus tag DM80_RS23205 Protein ID WP_025369732.1
Coordinates 1595729..1596007 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DM80_RS23185 1591312..1592463 - 1152 WP_048805412.1 efflux RND transporter periplasmic adaptor subunit -
DM80_RS23190 1592460..1593068 - 609 WP_004393990.1 TetR/AcrR family transcriptional regulator -
DM80_RS23195 1593210..1593470 - 261 WP_025369735.1 hypothetical protein -
DM80_RS34600 1594034..1594303 + 270 Protein_1443 mobilization protein -
DM80_RS23200 1594464..1595666 + 1203 WP_048805413.1 hypothetical protein -
DM80_RS23205 1595729..1596007 + 279 WP_025369732.1 CopG family ribbon-helix-helix protein Antitoxin
DM80_RS23210 1595995..1596285 + 291 WP_034188048.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DM80_RS34605 1596282..1596521 + 240 WP_144245534.1 hypothetical protein -
DM80_RS23215 1596559..1597551 - 993 WP_006412423.1 IS5-like element ISBmu2 family transposase -
DM80_RS36375 1597655..1597804 + 150 WP_158332655.1 hypothetical protein -
DM80_RS23220 1597884..1598159 + 276 WP_200885124.1 hypothetical protein -
DM80_RS23225 1598208..1598468 - 261 Protein_1451 hypothetical protein -
DM80_RS23230 1598688..1600199 + 1512 WP_027809980.1 IS21 family transposase -
DM80_RS23235 1600204..1600992 + 789 WP_012213993.1 IS21-like element ISBmu1 family helper ATPase IstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - cheD 1505074..1610035 104961


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-94)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10968.49 Da        Isoelectric Point: 9.5558

>T47313 WP_034188048.1 NZ_CP008730:1595995-1596285 [Burkholderia multivorans]
MPQVIFAPAAIRDLQRLRDFLRPKNPDAARRAGEAIRQGVQALGTHPRMGRLVEDLPEHYREWPIDFGDSGYVARYRLDG
ETVTILAVRHQKEAGY

Download         Length: 291 bp

>T47313 NZ_CP008730:1595995-1596285 [Burkholderia multivorans]
ATGCCGCAAGTGATCTTTGCGCCGGCGGCAATCCGAGACTTGCAACGGTTGCGCGACTTCCTGCGCCCGAAGAACCCTGA
CGCCGCGAGGCGGGCCGGCGAAGCAATTAGACAAGGCGTACAGGCTCTCGGCACCCACCCTCGAATGGGGCGTCTTGTAG
AAGACCTACCCGAGCATTATCGGGAGTGGCCCATCGATTTCGGGGATAGTGGTTACGTGGCCCGGTACCGCCTCGATGGC
GAAACCGTTACGATCTTGGCCGTCCGACATCAGAAGGAAGCGGGGTATTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10820.15 Da        Isoelectric Point: 5.2484

>AT47313 WP_025369732.1 NZ_CP008730:1595729-1596007 [Burkholderia multivorans]
MVTATSIKLDDELKGRVQHLAEARRRTPHWIMREAIEQYVEREEKRETLNKDTLKAWDEFQATGLHATAEEVDKWLASWG
TENELPTPECRK

Download         Length: 279 bp

>AT47313 NZ_CP008730:1595729-1596007 [Burkholderia multivorans]
ATGGTAACAGCGACATCTATCAAGCTCGATGACGAACTGAAAGGGCGAGTACAGCACTTGGCTGAAGCGCGTCGGCGAAC
CCCGCACTGGATCATGCGCGAAGCCATCGAGCAGTACGTCGAGCGCGAGGAAAAGCGGGAGACGTTGAACAAGGACACGC
TCAAGGCGTGGGATGAGTTTCAGGCGACTGGTCTACACGCGACCGCTGAAGAAGTGGATAAGTGGCTCGCGAGCTGGGGA
ACTGAAAACGAGCTGCCCACGCCCGAATGCCGCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8A8D2I2

Antitoxin

Source ID Structure
AlphaFold DB A0A8A8D2B6

References