Detailed information of TA system TA047312

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 226149..226733
• Replicon: chromosome
• Accession: NZ_CP008730
• Organism: Burkholderia multivorans strain DDS 15A-1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: DM80_RS16880
• Protein ID: WP_048804938.1
• Coordinates: 226149..226445 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: J4SGI3
• Locus tag: DM80_RS16885
• Protein ID: WP_006409266.1
• Coordinates: 226449..226733 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DM80_RS16860	221658..222758	-	1101	WP_048804937.1	chorismate synthase	-
DM80_RS16865	222927..224861	-	1935	WP_006413765.1	MFS transporter	-
DM80_RS16870	225009..225464	-	456	WP_006402096.1	CBS domain-containing protein	-
DM80_RS16875	225625..225942	+	318	WP_006402097.1	DUF962 domain-containing protein	-
DM80_RS16880	226149..226445	+	297	WP_048804938.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DM80_RS16885	226449..226733	+	285	WP_006409266.1	putative addiction module antidote protein	Antitoxin
DM80_RS16890	226816..227004	+	189	WP_035950261.1	hypothetical protein	-
DM80_RS16895	227171..228499	-	1329	WP_039224705.1	YihY family inner membrane protein	-
DM80_RS16900	228644..229255	+	612	WP_006402099.1	NAD(P)H:quinone oxidoreductase	-
DM80_RS16905	229252..229647	+	396	WP_048804939.1	DUF2069 domain-containing protein	-
DM80_RS16910	229666..231087	+	1422	WP_048806197.1	FAD-binding oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (1-97)

Antitoxin

• Uncharacterized protein HI1420 (5-90)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11301.04 Da
• Isoelectric Point: 9.7646

>T47312 WP_048804938.1 NZ_CP008730:226149-226445 [Burkholderia multivorans]
MVTLLRSTEFNDWLANLRDQRGKARITARLISAQLGNFGEYRVLDEGVCELKIDFGPGYRVYYVRRGEVVYLLLCGGDKS
TQRKDIKRAAQMARELKE

Nucleotide

• Length: 297 bp

>T47312 NZ_CP008730:226149-226445 [Burkholderia multivorans]
ATGGTTACTTTGCTGCGATCCACGGAGTTCAACGATTGGCTTGCCAACCTGCGCGATCAGCGCGGCAAGGCCCGAATCAC
AGCCCGCCTGATCAGCGCGCAGCTCGGCAACTTCGGCGAGTACCGTGTGCTCGACGAAGGGGTCTGCGAACTGAAGATCG
ATTTCGGGCCGGGCTACCGCGTGTATTACGTTCGACGCGGCGAAGTGGTCTACCTCCTTCTGTGCGGCGGCGACAAGTCA
ACGCAACGGAAGGACATCAAGCGCGCCGCGCAGATGGCGCGCGAACTGAAGGAGTAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 9986.38 Da
• Isoelectric Point: 6.2121

>AT47312 WP_006409266.1 NZ_CP008730:226449-226733 [Burkholderia multivorans]
MTNYTEFDAADYLDNDEAVAEFLAVAAEDPNPDVFLAAVAAVARARGMTKVAAAAGVGRVALHKALTPGAHPRYETVQKI
IRSLGLRMSFTVAH

Nucleotide

• Length: 285 bp

>AT47312 NZ_CP008730:226449-226733 [Burkholderia multivorans]
ATGACCAACTACACCGAGTTCGATGCGGCCGATTACCTCGACAACGATGAGGCGGTCGCGGAATTCCTCGCCGTCGCGGC
AGAGGACCCGAATCCCGACGTGTTCCTCGCGGCCGTCGCTGCGGTCGCGCGGGCGCGCGGTATGACGAAGGTTGCGGCCG
CCGCCGGCGTCGGCCGCGTCGCGCTTCACAAGGCACTGACGCCCGGCGCGCACCCGCGCTACGAAACCGTGCAGAAAATC
ATCCGGTCGCTCGGCCTGCGCATGAGCTTCACGGTCGCGCACTAA

Structures

Antitoxin

• AlphaFold DB: J4SGI3