Detailed information of TA system TA047308

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 1944389..1945659
• Replicon: chromosome
• Accession: NZ_CP008729
• Organism: Burkholderia multivorans strain DDS 15A-1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: DM80_RS13470
• Protein ID: WP_048804460.1
• Coordinates: 1944389..1944967 (-)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: DM80_RS13475
• Protein ID: WP_048804461.1
• Coordinates: 1945102..1945659 (-)
• Length: 186 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DM80_RS13450	1939677..1940468	+	792	WP_048804457.1	enoyl-CoA hydratase	-
DM80_RS13455	1940465..1941604	+	1140	WP_048804458.1	enoyl-CoA hydratase/isomerase family protein	-
DM80_RS13460	1941657..1942577	-	921	WP_035955455.1	LysR family transcriptional regulator	-
DM80_RS13465	1942756..1944294	+	1539	WP_048804459.1	MFS transporter	-
DM80_RS13470	1944389..1944967	-	579	WP_048804460.1	HD domain-containing protein	Toxin
DM80_RS13475	1945102..1945659	-	558	WP_048804461.1	helix-turn-helix domain-containing protein	Antitoxin
DM80_RS13480	1946170..1947573	+	1404	WP_048804462.1	membrane protein	-
DM80_RS13485	1947915..1948646	+	732	WP_035955446.1	ribonuclease T2	-
DM80_RS13490	1948819..1949457	-	639	WP_048804463.1	cysteine hydrolase	-
DM80_RS13495	1949563..1950579	-	1017	WP_006412465.1	AraC family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HD domain (16-172)

Antitoxin

• Cro/C1-type helix-turn-helix domain (12-64)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21279.98 Da
• Isoelectric Point: 5.3191

>T47308 WP_048804460.1 NZ_CP008729:c1944967-1944389 [Burkholderia multivorans]
MNPDTIRARLDFLREAERLKDVLRSGRTSSGRRESTAEHSWRLCLMALVSADALPGIDTLKLLKLCVVHDLGEALHGDIP
ATEQAAHPDKNLHERDDLLTLTAALDPVLRNELVALWDEYDAAASPEARAAKALDKLETILQHTQGANPPDFDYAFNLGY
GRRYTDAAPLFSAIRAIVDADTQRRIDAQART

Nucleotide

• Length: 579 bp

>T47308 NZ_CP008729:c1944967-1944389 [Burkholderia multivorans]
ATGAACCCCGACACGATCCGCGCACGGCTCGATTTCCTGCGCGAAGCCGAACGCCTGAAGGACGTGCTGCGCAGCGGCCG
CACGTCGTCCGGTCGCCGCGAAAGCACCGCCGAGCACAGCTGGCGGCTGTGCCTGATGGCGCTCGTGTCCGCCGACGCAC
TGCCCGGCATCGACACGCTGAAGCTGCTCAAGCTGTGCGTCGTCCACGATCTCGGCGAGGCGCTGCACGGCGACATACCG
GCGACCGAGCAAGCCGCGCATCCGGACAAGAACCTGCACGAACGCGACGACCTGCTCACGCTGACGGCCGCACTCGATCC
CGTGCTGCGTAACGAACTCGTCGCACTGTGGGACGAATACGATGCGGCCGCGTCGCCCGAAGCGCGCGCCGCGAAGGCGC
TCGACAAGCTCGAGACGATTCTGCAGCACACGCAGGGCGCCAATCCGCCCGACTTCGACTACGCGTTCAATCTCGGCTAC
GGCCGGCGCTATACGGATGCGGCACCGCTATTCAGCGCGATCCGGGCGATCGTCGATGCGGACACGCAGCGCAGGATCGA
CGCGCAAGCACGAACGTAA

Antitoxin

Protein

• Length: 186 a.a.
• Molecular weight: 20349.35 Da
• Isoelectric Point: 8.5490

>AT47308 WP_048804461.1 NZ_CP008729:c1945659-1945102 [Burkholderia multivorans]
MPDSPLHTPPLGPQLKRWRLLHRVKQSHAAALFGVAQSTISRWEAGVQQMSPDERATAERLLAARLDSAGDHALARLVAG
SAGRMHLVCDLTHRLLACSPSRAAEFSQPLPMLLGTSLWRYATEEIVRMETALDTLGWHDCAGPPSVEFDTGTNASRVVP
IHRSRCRWTRIMLSDGSAARLVETL

Nucleotide

• Length: 558 bp

>AT47308 NZ_CP008729:c1945659-1945102 [Burkholderia multivorans]
ATGCCCGATTCGCCGCTTCATACGCCGCCGCTCGGCCCGCAGCTGAAACGCTGGCGCCTGCTGCATCGCGTCAAGCAAAG
CCATGCCGCCGCGCTATTCGGCGTCGCGCAATCGACGATCTCGCGCTGGGAAGCCGGCGTCCAGCAGATGTCGCCCGACG
AGCGCGCGACGGCGGAACGTCTGCTCGCCGCGCGCCTCGACTCCGCGGGCGACCATGCGCTCGCGCGGCTGGTCGCAGGG
AGCGCGGGCCGCATGCATCTCGTCTGCGATCTGACGCACCGGCTGCTTGCATGCTCGCCGTCTCGCGCAGCCGAGTTCTC
GCAGCCGCTGCCGATGCTGCTCGGCACGTCGCTGTGGCGCTACGCGACAGAAGAAATCGTCCGGATGGAAACCGCACTGG
ACACACTCGGCTGGCACGACTGCGCAGGACCGCCGAGCGTCGAATTCGACACCGGCACGAACGCATCGCGCGTCGTGCCG
ATCCACCGCAGCCGATGCCGCTGGACGCGGATCATGCTGTCGGACGGGTCGGCGGCACGGCTCGTCGAAACGCTGTAG