47305

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 70124..70658 Replicon chromosome
Accession NZ_CP008729
Organism Burkholderia multivorans strain DDS 15A-1

Toxin (Protein)


Gene name parE Uniprot ID J4RBB5
Locus tag DM80_RS05300 Protein ID WP_006413674.1
Coordinates 70124..70423 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID J4RB90
Locus tag DM80_RS05305 Protein ID WP_006413656.1
Coordinates 70413..70658 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DM80_RS05285 66474..67781 + 1308 WP_012216990.1 shikimate transporter -
DM80_RS05290 67815..68543 - 729 WP_048803632.1 HNH endonuclease -
DM80_RS05295 68714..70015 + 1302 WP_006413706.1 UDP-N-acetylglucosamine 1-carboxyvinyltransferase -
DM80_RS05300 70124..70423 - 300 WP_006413674.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DM80_RS05305 70413..70658 - 246 WP_006413656.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
DM80_RS05310 70797..71567 + 771 WP_006403543.1 helix-turn-helix domain-containing protein -
DM80_RS05315 71612..73912 - 2301 WP_048804736.1 ATP-dependent DNA helicase -
DM80_RS05320 73909..75612 - 1704 WP_048803633.1 VRR-NUC domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-94)

Antitoxin

Antitoxin ParD

(1-80)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11542.08 Da        Isoelectric Point: 8.4461

>T47305 WP_006413674.1 NZ_CP008729:c70423-70124 [Burkholderia multivorans]
MPVKARTVRLTPLAEADLEAIWAYTYERWSLGQAERYIGELSTAFERLARRESVGWPSRAGGNYSRYLVGSHVVFYRETT
ETLDVIRVLHQRMDVDRHL

Download         Length: 300 bp

>T47305 NZ_CP008729:c70423-70124 [Burkholderia multivorans]
ATGCCGGTTAAGGCGCGCACGGTACGCCTGACGCCACTGGCGGAGGCCGATCTCGAGGCCATCTGGGCTTACACGTACGA
GCGCTGGTCACTCGGCCAGGCTGAGCGCTATATCGGCGAGCTGAGCACGGCGTTCGAGCGGCTGGCGCGCCGGGAGTCGG
TAGGGTGGCCGAGTCGCGCGGGCGGCAACTATTCGCGCTACCTGGTCGGTTCGCACGTGGTGTTCTATCGGGAAACGACC
GAAACCCTTGACGTCATTCGCGTGCTGCACCAGCGGATGGATGTCGACCGACATCTGTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8632.71 Da        Isoelectric Point: 6.4604

>AT47305 WP_006413656.1 NZ_CP008729:c70658-70413 [Burkholderia multivorans]
MARNTSISLGDHLAEFVDMQVASGRYGSASDVVRAGLRLLETQETELRALQEALKAGEASGTPAPFDSQAFLARMRAKHA
G

Download         Length: 246 bp

>AT47305 NZ_CP008729:c70658-70413 [Burkholderia multivorans]
ATGGCACGAAATACATCGATCTCGCTGGGCGATCATCTGGCCGAATTTGTCGACATGCAGGTCGCGTCCGGCCGCTACGG
CTCGGCTAGCGATGTCGTGCGCGCGGGCCTGCGCCTGCTCGAGACACAGGAAACCGAGCTGCGGGCGCTGCAGGAAGCGT
TGAAGGCGGGCGAGGCATCGGGCACACCGGCCCCGTTCGACAGCCAGGCGTTCCTGGCCCGGATGCGGGCCAAGCATGCC
GGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3KLL7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3KUX0

References