Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1582308..1584055 Replicon chromosome
Accession NZ_CP008727
Organism Burkholderia oklahomensis strain EO147

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag DM82_RS25630 Protein ID WP_010108748.1
Coordinates 1582308..1583204 (+) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag DM82_RS25635 Protein ID WP_010108749.1
Coordinates 1583201..1584055 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DM82_RS25600 1577711..1578799 - 1089 WP_010108741.1 porin -
DM82_RS25605 1579233..1579550 + 318 WP_010108742.1 non-heme iron oxygenase ferredoxin subunit -
DM82_RS25610 1579552..1579863 + 312 WP_010108743.1 hypothetical protein -
DM82_RS25615 1579898..1580965 + 1068 WP_041282028.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
DM82_RS25620 1580962..1581732 + 771 WP_010118458.1 SDR family oxidoreductase -
DM82_RS25625 1581764..1582291 + 528 WP_010108747.1 cupin domain-containing protein -
DM82_RS25630 1582308..1583204 + 897 WP_010108748.1 alpha/beta fold hydrolase Toxin
DM82_RS25635 1583201..1584055 + 855 WP_010108749.1 IclR family transcriptional regulator Antitoxin
DM82_RS25640 1584052..1584849 + 798 WP_010108750.1 SDR family oxidoreductase -
DM82_RS25645 1584842..1586515 + 1674 WP_041282030.1 thiamine pyrophosphate-binding protein -
DM82_RS25650 1586508..1587323 + 816 WP_010108754.1 aspartate dehydrogenase -
DM82_RS25655 1587355..1588845 + 1491 WP_010108755.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-280)

Antitoxin

Transcription regulator IclR, N-terminal

(23-71)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30711.76 Da        Isoelectric Point: 7.3485

>T47302 WP_010108748.1 NZ_CP008727:1582308-1583204 [Burkholderia oklahomensis]
MSAISVTTNDIGATPFAELLERFPERRAAAGAAGAIGYREAGDARGERCPVVLLHGIGSGAASWVRQLDTLGATRRALAW
DAPGYGASSRVAAESPVAADYAASLDAWLDALRIERCVLVGHSLGAIVAGAFARAAGERLSGLLLISPAGGYGSAPADVR
AERRDSRLALLASLGPQGLAEQRSANMLSAHASDAARAWVRWNMARIVPAGYAQATHLLANADLATDLVHYRGRVAVAVG
ADDAITPPAACERIAQAARVGLQVIPRAGHAGYVEAPDAYGALIDAFCRQCDGLRGAA

Download         Length: 897 bp

>T47302 NZ_CP008727:1582308-1583204 [Burkholderia oklahomensis]
ATGAGCGCGATTTCCGTGACGACGAACGACATCGGCGCGACGCCGTTCGCCGAACTGCTCGAACGCTTTCCCGAGCGGCG
CGCGGCGGCGGGCGCCGCGGGCGCGATCGGTTACCGCGAGGCCGGCGACGCGCGCGGCGAGCGCTGTCCCGTCGTGCTGT
TGCACGGGATCGGGTCGGGTGCGGCGTCGTGGGTGCGGCAGCTCGATACGCTCGGCGCGACGCGCCGTGCGCTCGCGTGG
GACGCGCCCGGCTACGGCGCGTCGTCGCGCGTCGCCGCCGAGTCGCCCGTCGCGGCCGATTACGCAGCGTCGCTCGACGC
ATGGCTCGACGCGCTGCGGATCGAGCGCTGCGTGCTCGTCGGCCACTCGCTCGGCGCGATCGTCGCCGGTGCGTTCGCGC
GCGCCGCGGGCGAGCGTCTTTCAGGATTGCTGTTGATTTCGCCCGCGGGCGGCTATGGCAGCGCGCCCGCCGACGTGCGG
GCCGAGCGGCGCGACAGCCGTCTCGCGCTGCTCGCGTCGCTCGGCCCGCAAGGGCTCGCCGAGCAGCGCAGCGCGAACAT
GCTGTCCGCGCATGCGAGCGACGCGGCGCGCGCATGGGTGCGCTGGAACATGGCGCGGATCGTGCCCGCCGGCTACGCAC
AGGCGACGCACCTGCTCGCGAACGCCGATCTCGCGACCGATCTCGTGCATTACCGCGGCCGCGTCGCGGTCGCGGTCGGC
GCGGACGACGCGATCACGCCGCCCGCAGCATGCGAGCGGATCGCGCAAGCGGCGCGCGTCGGGCTGCAGGTGATCCCGCG
CGCGGGTCACGCGGGCTACGTAGAAGCACCCGATGCGTATGGCGCGCTGATCGACGCGTTTTGCCGTCAGTGCGACGGAC
TGCGAGGTGCGGCATGA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 30991.45 Da        Isoelectric Point: 6.6554

>AT47302 WP_010108749.1 NZ_CP008727:1583201-1584055 [Burkholderia oklahomensis]
MSEPLLKDADDAKNDSNYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYRL
GVAVLRLGFEYLSSLELTDLGLPVIEGLRDATGFTTHIVIRDGRDVVFVAKAQNAGHAFGSVRVNVGTRLPAHATTHGHV
LMGDLSLAQLCALYPEPALERVTKATPETVDALFSVIRDDARRGYGIGNSAFERDISVVTAPVRNDASKIVAVVTVTVPR
PEIDASLVADGLIDKVLRAAAELSRRLNYRPDDENTYLKALGLR

Download         Length: 855 bp

>AT47302 NZ_CP008727:1583201-1584055 [Burkholderia oklahomensis]
ATGAGCGAACCGCTGCTGAAAGACGCCGACGACGCGAAAAACGATTCGAACTACGTAGTACCGGGGCTCGAGCGCGGTCT
GCGGATTCTCGCGGAGTTCTCGCCGCGCGAGCCGGTGCTCGGCGCGCCGGAGCTGTCGAAGCGGCTCGGCATTCCGCGCA
CGACGGTGTTCCGTCTGCTGCAAACGCTCGAATCGCTCGGTTTTCTCGAGCGCGCGGACAAGGATCGCAATTATCGATTG
GGCGTCGCGGTGCTGCGCCTCGGCTTCGAATACCTGAGCTCGCTCGAGCTGACCGATCTCGGCTTGCCGGTGATCGAAGG
CCTGCGTGACGCGACGGGCTTCACGACGCACATCGTGATCCGCGACGGCCGCGACGTCGTGTTCGTCGCGAAGGCGCAGA
ATGCGGGGCACGCGTTCGGCTCGGTGCGGGTGAACGTCGGCACGCGCTTGCCCGCGCATGCGACGACGCACGGCCACGTG
CTGATGGGCGACCTGTCGCTCGCTCAGTTATGCGCGCTGTATCCGGAGCCGGCGCTCGAGCGCGTGACGAAGGCGACGCC
CGAGACCGTCGACGCGCTCTTCAGCGTGATCCGCGACGACGCGCGGCGCGGCTACGGGATCGGCAACTCGGCGTTCGAGC
GCGACATCTCGGTCGTCACGGCGCCGGTGCGCAACGACGCGAGCAAGATCGTCGCCGTCGTCACGGTGACGGTGCCGCGG
CCGGAGATCGACGCGTCGCTCGTCGCCGACGGGCTGATCGACAAGGTGCTGCGCGCGGCGGCGGAGCTGTCGCGGCGGCT
GAACTACCGGCCCGACGACGAAAACACCTATTTGAAGGCATTGGGATTGCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References