Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 913676..914184 Replicon chromosome
Accession NZ_CP008724
Organism Staphylococcus xylosus strain SMQ-121

Toxin (Protein)


Gene name TsdT Uniprot ID A0A5R9B1P1
Locus tag SXYLSMQ121_RS04165 Protein ID WP_042362331.1
Coordinates 913984..914184 (+) Length 67 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A418I4X8
Locus tag SXYLSMQ121_RS04160 Protein ID WP_029377967.1
Coordinates 913676..913969 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SXYLSMQ121_RS04135 908792..909580 + 789 WP_042362327.1 hydroxyethylthiazole kinase -
SXYLSMQ121_RS04140 909583..910221 + 639 WP_042362328.1 thiamine phosphate synthase -
SXYLSMQ121_RS04145 910309..911178 + 870 WP_029377970.1 membrane protein insertase YidC -
SXYLSMQ121_RS04150 911290..911898 - 609 WP_171031846.1 HD domain-containing protein -
SXYLSMQ121_RS04155 912049..913533 - 1485 WP_042362330.1 cardiolipin synthase -
SXYLSMQ121_RS04160 913676..913969 + 294 WP_029377967.1 copper-sensing transcriptional repressor CsoR Antitoxin
SXYLSMQ121_RS04165 913984..914184 + 201 WP_042362331.1 heavy-metal-associated domain-containing protein Toxin
SXYLSMQ121_RS12985 914400..914540 + 141 WP_099265859.1 hypothetical protein -
SXYLSMQ121_RS04170 914884..916089 - 1206 WP_042362332.1 rod shape-determining protein RodA -
SXYLSMQ121_RS04175 916341..917411 + 1071 WP_038678888.1 D-alanine--D-alanine ligase -
SXYLSMQ121_RS04180 917424..918779 + 1356 WP_042362333.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(19-64)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 67 a.a.        Molecular weight: 7517.53 Da        Isoelectric Point: 4.5845

>T47294 WP_042362331.1 NZ_CP008724:913984-914184 [Staphylococcus xylosus]
VQSKVIYVSGINSERQYQIKQRLMNVIGVHSVAIDSDKGEILVDFETPASLNNLEKEIYDLGYQIF

Download         Length: 201 bp

>T47294 NZ_CP008724:913984-914184 [Staphylococcus xylosus]
GTGCAATCAAAAGTAATTTACGTCTCAGGTATTAATTCAGAACGACAATATCAAATAAAACAACGATTAATGAATGTTAT
AGGTGTACACAGTGTTGCTATAGATAGTGATAAAGGAGAAATACTTGTCGATTTTGAAACACCTGCGAGTTTAAATAATT
TGGAAAAAGAAATTTATGATCTTGGATATCAAATATTTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11195.85 Da        Isoelectric Point: 6.8624

>AT47294 WP_029377967.1 NZ_CP008724:913676-913969 [Staphylococcus xylosus]
VTEIQKAHHSDQIKSNLKSRLNRIEGQVRAINRMVDEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVEKGQQ
EEAMEELLVTFQKLMKD

Download         Length: 294 bp

>AT47294 NZ_CP008724:913676-913969 [Staphylococcus xylosus]
GTGACAGAAATACAAAAAGCGCATCATTCAGACCAAATAAAATCAAATTTGAAATCAAGACTAAATAGAATAGAAGGACA
AGTGCGAGCAATAAACCGTATGGTAGATGAAGATGTTTATTGTGACGATGTACTTACTCAAATTAGAGCGACACGTTCTG
CACTAAATAGCGTAGCAACTAAATTGTTGGATCATCATATGAAAAGTTGCATCATGGATAAAGTGGAAAAAGGTCAACAA
GAAGAAGCAATGGAAGAGTTATTAGTAACTTTTCAAAAATTAATGAAGGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5R9B1P1

Antitoxin

Source ID Structure
AlphaFold DB A0A418I4X8

References