Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 353723..354711 Replicon chromosome
Accession NZ_CP008697
Organism Escherichia coli strain ST648 isolate Pleural Effusion of Patients with Empyema Thoracis

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag FH07_RS01730 Protein ID WP_014640052.1
Coordinates 354325..354711 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID -
Locus tag FH07_RS01725 Protein ID WP_060684349.1
Coordinates 353723..354295 (+) Length 191 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FH07_RS01700 348793..349401 + 609 WP_000646078.1 transcriptional repressor LexA -
FH07_RS01705 349474..350799 + 1326 WP_001361471.1 MATE family efflux transporter DinF -
FH07_RS01710 350915..351124 + 210 WP_001296638.1 CsbD family protein -
FH07_RS01715 351166..351681 - 516 WP_000416263.1 zinc uptake transcriptional repressor Zur -
FH07_RS01720 351999..353003 + 1005 WP_022646425.1 DUF2713 family protein -
FH07_RS25870 353365..353487 + 123 WP_001300034.1 hypothetical protein -
FH07_RS01725 353723..354295 + 573 WP_060684349.1 SocA family protein Antitoxin
FH07_RS01730 354325..354711 + 387 WP_014640052.1 hypothetical protein Toxin
FH07_RS28735 354751..354924 + 174 WP_023908888.1 hypothetical protein -
FH07_RS01735 354972..355253 - 282 WP_001093916.1 pyocin activator PrtN family protein -
FH07_RS01740 355290..356042 - 753 WP_024946495.1 hypothetical protein -
FH07_RS01745 356261..357085 - 825 WP_023908886.1 DUF2303 family protein -
FH07_RS01750 357151..357513 - 363 WP_000135686.1 hypothetical protein -
FH07_RS01755 358181..358855 - 675 WP_021530636.1 LexA family transcriptional regulator -
FH07_RS01760 358946..359146 + 201 WP_021527487.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 348793..396769 47976


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(27-137)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14465.40 Da        Isoelectric Point: 5.4833

>T47226 WP_014640052.1 NZ_CP008697:354325-354711 [Escherichia coli]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Download         Length: 387 bp

>T47226 NZ_CP008697:354325-354711 [Escherichia coli]
GTGCTTGCCCCAACTGGGCCATGCAATCATCTTCATGTGATTTGTAATGATCCTGTTTATTACCCCGTTAACGATTGTTA
TTGTGTTTTAGTTGTTAATATTTCTAGTATCAAGGATGGTGTCCCCCACGATCCGTCTTGCGTCTTGAATTCTGGTGATC
ATCGCTTTATCAAGCATCCAAGTTATGTTGTTTACGCTGAAGCTATAATTTGGCGAGTGGATAACATGGTTAGAAAGCAG
CGATCGGGTGAGATTTCTGTTCATGATGATATGCCAGAAGCTACATTCAATAGAATTCTGGACGGTTTTGATATATCTGA
TGAAGTTACGCCAAAGAACCTTAAATTTAAAAATAAATATTGCGTATCATCTATTGATGATGAGTAA

Antitoxin


Download         Length: 191 a.a.        Molecular weight: 21946.26 Da        Isoelectric Point: 6.0283

>AT47226 WP_060684349.1 NZ_CP008697:353723-354295 [Escherichia coli]
MFCEEKVAQMAAYLLLKRGGRMAYLKLMKLLYLSNRKSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYN
LIETNGHDVLLRSDPREMDADEVFDELSRADIRILDEIYSLYGHMNRFDLANMTHLESVCPEWHNSGNSRKPIDLKEMLI
SEGKSEDEANRIIGKMEESQKLKEFSLQLS

Download         Length: 573 bp

>AT47226 NZ_CP008697:353723-354295 [Escherichia coli]
ATGTTTTGCGAAGAAAAAGTAGCTCAAATGGCTGCATACCTACTTCTTAAGCGAGGTGGGCGCATGGCATATCTGAAATT
GATGAAGCTGCTCTATCTGTCTAACCGCAAGTCGATTTTGAAGCATGGCAGGATGATCGGCGAAGATAGTCTTTACTCTA
TGAAATTTGGTCCAGTCATGTCGAATACGCTGAACTTGATTCGTGGTAAGGCTGAAGGCATTGGTGACTACTGGTACAAC
TTGATAGAGACGAACGGGCATGATGTGTTGTTGCGTTCAGATCCGAGGGAAATGGATGCAGACGAGGTCTTTGATGAGTT
GAGCCGTGCAGATATCCGGATTTTAGATGAAATCTATTCTCTGTATGGGCATATGAACCGATTTGATCTCGCAAACATGA
CGCATTTAGAAAGCGTTTGTCCAGAGTGGCATAATTCTGGCAATTCTCGTAAGCCTATAGACCTGAAAGAAATGCTGATC
AGTGAGGGTAAAAGCGAGGATGAGGCTAATCGTATAATTGGCAAAATGGAAGAATCTCAGAAACTTAAGGAATTTTCTTT
GCAATTATCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References