Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 6248836..6249425 Replicon chromosome
Accession NZ_CP008696
Organism Pseudomonas chlororaphis strain PA23

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag EY04_RS27780 Protein ID WP_028683468.1
Coordinates 6249126..6249425 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag EY04_RS27775 Protein ID WP_007924096.1
Coordinates 6248836..6249129 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EY04_RS27755 6244377..6245540 - 1164 WP_016702677.1 acyltransferase -
EY04_RS27760 6245735..6246925 - 1191 WP_028683472.1 serine hydrolase -
EY04_RS27765 6247052..6247939 + 888 WP_009051074.1 LysR family transcriptional regulator -
EY04_RS27770 6248311..6248703 + 393 WP_009051075.1 hypothetical protein -
EY04_RS27775 6248836..6249129 - 294 WP_007924096.1 putative addiction module antidote protein Antitoxin
EY04_RS27780 6249126..6249425 - 300 WP_028683468.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EY04_RS27785 6249596..6250045 + 450 WP_038635536.1 DUF3828 domain-containing protein -
EY04_RS27790 6250070..6251080 - 1011 WP_173424526.1 NAD(P)-dependent alcohol dehydrogenase -
EY04_RS27795 6251138..6251437 - 300 WP_009051080.1 ArsR family transcriptional regulator -
EY04_RS27800 6251501..6252592 - 1092 WP_009051081.1 nitrite reductase, copper-containing -
EY04_RS27805 6252818..6253060 + 243 WP_007924102.1 exodeoxyribonuclease VII small subunit -
EY04_RS27810 6253057..6253944 + 888 WP_038575447.1 (2E,6E)-farnesyl diphosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-96)

Antitoxin

Uncharacterized protein HI1420

(6-91)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11256.97 Da        Isoelectric Point: 10.4277

>T47224 WP_028683468.1 NZ_CP008696:c6249425-6249126 [Pseudomonas chlororaphis]
MIEIKQTATFMEWENRLKDSRARALIAARIFRLANGLAGDVSPVGEGVSELRIHYGPGYRVYFQQLGSQLVILLCGGDKS
RQSRDIELAKYLARRWSRS

Download         Length: 300 bp

>T47224 NZ_CP008696:c6249425-6249126 [Pseudomonas chlororaphis]
ATGATCGAGATCAAACAGACCGCGACCTTTATGGAGTGGGAAAACAGGCTCAAGGATTCCAGAGCCAGGGCGTTGATCGC
TGCGCGGATTTTTCGCCTGGCCAACGGCCTTGCCGGGGACGTGTCCCCGGTGGGCGAGGGCGTCAGCGAGTTGCGCATCC
ATTACGGGCCGGGCTACCGAGTTTATTTCCAGCAGCTTGGTTCGCAACTTGTCATTTTGTTATGCGGCGGCGACAAGAGT
CGCCAGAGCCGCGATATCGAACTGGCCAAATACCTGGCCCGTCGTTGGAGTCGATCATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10430.94 Da        Isoelectric Point: 5.6558

>AT47224 WP_007924096.1 NZ_CP008696:c6249129-6248836 [Pseudomonas chlororaphis]
MNEPLFDYDPATALRDPQAIALFMADAFETGDAGYIAKALGVVARAKGMTELAHETGLSREQLYRSFSDKGNPTLKTLLA
VMRALGLDMTARVHGAS

Download         Length: 294 bp

>AT47224 NZ_CP008696:c6249129-6248836 [Pseudomonas chlororaphis]
ATGAACGAACCGCTATTCGACTATGACCCCGCCACGGCCTTGCGCGACCCGCAGGCCATCGCCCTGTTCATGGCGGACGC
CTTCGAGACCGGCGATGCCGGCTACATCGCCAAAGCCCTGGGCGTGGTGGCGCGGGCCAAGGGCATGACCGAACTGGCCC
ATGAAACCGGGCTGTCCCGCGAGCAGCTGTACCGCTCGTTCAGTGACAAGGGCAACCCGACCCTGAAGACCCTGCTGGCG
GTGATGCGCGCCCTGGGGCTGGACATGACGGCGCGGGTGCATGGGGCGTCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References