Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 1409022..1409550 Replicon chromosome
Accession NZ_CP008696
Organism Pseudomonas chlororaphis strain PA23

Toxin (Protein)


Gene name relE Uniprot ID A0A7S5LMJ4
Locus tag EY04_RS06200 Protein ID WP_038581545.1
Coordinates 1409022..1409321 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7S5HLJ1
Locus tag EY04_RS06205 Protein ID WP_038581543.1
Coordinates 1409311..1409550 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EY04_RS06180 1404814..1405596 - 783 WP_016702096.1 aldolase -
EY04_RS06185 1405756..1406298 + 543 WP_007922237.1 XRE family transcriptional regulator -
EY04_RS06190 1406623..1407642 - 1020 WP_038630801.1 DUF4917 family protein -
EY04_RS06195 1407800..1408948 + 1149 WP_038630803.1 L-threonine dehydrogenase -
EY04_RS06200 1409022..1409321 - 300 WP_038581545.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EY04_RS06205 1409311..1409550 - 240 WP_038581543.1 ribbon-helix-helix protein, CopG family Antitoxin
EY04_RS06210 1409687..1410103 + 417 WP_009047448.1 fosfomycin resistance glutathione transferase -
EY04_RS06215 1410231..1410869 + 639 WP_016702101.1 LysE family translocator -
EY04_RS06220 1410981..1412321 + 1341 WP_016702102.1 sensor domain-containing diguanylate cyclase -
EY04_RS06225 1412459..1412983 + 525 WP_009047451.1 DUF4142 domain-containing protein -
EY04_RS06230 1413077..1413967 - 891 WP_038630805.1 phosphotransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-82)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-41)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11487.13 Da        Isoelectric Point: 10.8916

>T47220 WP_038581545.1 NZ_CP008696:c1409321-1409022 [Pseudomonas chlororaphis]
MHVEWLRSALKNLDDEAAYIAQDSPQAAAEFVKAILSSIQHLSRFPASGREGRLPGTREWVVPNRPYLIPYRVRQGRLQI
LRIFHTRRLPPAGWQDDRQ

Download         Length: 300 bp

>T47220 NZ_CP008696:c1409321-1409022 [Pseudomonas chlororaphis]
ATGCACGTTGAGTGGCTACGCAGCGCCCTCAAGAACCTCGATGACGAAGCCGCCTACATTGCACAGGACAGTCCTCAGGC
CGCCGCGGAATTCGTCAAAGCCATCCTGAGTAGCATTCAACACCTGAGCCGTTTTCCTGCCAGTGGTCGCGAAGGTCGCC
TGCCCGGTACCCGGGAGTGGGTGGTCCCCAATCGTCCTTACCTGATCCCCTACCGCGTACGTCAGGGACGCCTGCAGATA
CTGCGGATTTTCCACACCCGGCGCTTGCCGCCTGCCGGTTGGCAAGACGACCGCCAATAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8648.73 Da        Isoelectric Point: 4.5535

>AT47220 WP_038581543.1 NZ_CP008696:c1409550-1409311 [Pseudomonas chlororaphis]
MSVMSLRLPDDVADTLAHLAKATGRSKSFLAVDALREYLAREAWQINEIQKALTEAEAGDFASAEELDGVLNKWTGNAR

Download         Length: 240 bp

>AT47220 NZ_CP008696:c1409550-1409311 [Pseudomonas chlororaphis]
ATGTCCGTCATGTCCTTGCGCCTGCCCGATGATGTTGCCGATACCCTGGCTCACTTGGCCAAGGCGACAGGCCGCAGCAA
GTCATTCCTCGCTGTGGATGCACTGAGAGAATATCTGGCCCGCGAAGCCTGGCAAATCAACGAGATCCAGAAAGCCCTGA
CTGAAGCAGAGGCAGGCGACTTCGCCAGCGCCGAAGAGCTGGATGGCGTACTCAACAAATGGACTGGCAATGCACGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7S5LMJ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7S5HLJ1

References