Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbE-relB/ParE-YafN
Location 82974..83490 Replicon chromosome
Accession NZ_CP008696
Organism Pseudomonas chlororaphis strain PA23

Toxin (Protein)


Gene name stbE Uniprot ID A0A8A9Z863
Locus tag EY04_RS00265 Protein ID WP_028681510.1
Coordinates 83209..83490 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A554PKE4
Locus tag EY04_RS00260 Protein ID WP_009046356.1
Coordinates 82974..83219 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EY04_RS00235 78742..79737 + 996 WP_038630330.1 aspartyl beta-hydroxylase -
EY04_RS00240 79703..80461 - 759 WP_009046352.1 slipin family protein -
EY04_RS00245 80463..81848 - 1386 WP_009046353.1 nodulation protein NfeD -
EY04_RS00250 82072..82533 + 462 WP_016705004.1 YbaK/EbsC family protein -
EY04_RS00255 82664..82909 + 246 WP_009046355.1 DUF2789 domain-containing protein -
EY04_RS00260 82974..83219 + 246 WP_009046356.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EY04_RS00265 83209..83490 + 282 WP_028681510.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EY04_RS00270 83623..84051 + 429 WP_009046358.1 winged helix DNA-binding protein -
EY04_RS00275 84048..86132 + 2085 WP_016705005.1 FUSC family protein -
EY04_RS00280 86129..86338 + 210 WP_007932080.1 DUF1656 domain-containing protein -
EY04_RS00285 86335..87231 + 897 WP_038630331.1 HlyD family secretion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(8-70)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10907.82 Da        Isoelectric Point: 10.6258

>T47217 WP_028681510.1 NZ_CP008696:83209-83490 [Pseudomonas chlororaphis]
MTYKLQFLPSARKEWDKLGHTLREQFKRKLAERLEMPRVPADALHGMADCYKIKLKASGYRLVYQVIEDQVVVSVVAVGK
RERSAVYERARKR

Download         Length: 282 bp

>T47217 NZ_CP008696:83209-83490 [Pseudomonas chlororaphis]
ATGACTTATAAGCTCCAGTTCCTGCCTTCGGCGCGCAAGGAATGGGACAAGCTCGGTCATACCCTGCGCGAGCAATTCAA
GAGGAAGCTGGCCGAGCGCCTGGAAATGCCGCGGGTGCCCGCGGACGCCCTTCACGGTATGGCGGACTGCTACAAGATCA
AGCTCAAGGCCTCTGGCTATCGCCTGGTTTACCAAGTGATCGAGGATCAGGTCGTGGTTTCGGTGGTGGCCGTGGGCAAA
CGTGAACGCAGTGCCGTGTATGAGCGGGCCCGAAAGCGCTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8814.14 Da        Isoelectric Point: 4.7164

>AT47217 WP_009046356.1 NZ_CP008696:82974-83219 [Pseudomonas chlororaphis]
MQSVLADKAVSVSELKKNPSAVLNGAQGGAVAVLNHNRVMGYMVPADVFEAMMERLDDLELAEIVRARRHETPVPVNLDD
L

Download         Length: 246 bp

>AT47217 NZ_CP008696:82974-83219 [Pseudomonas chlororaphis]
ATGCAAAGCGTATTGGCTGATAAAGCTGTCAGCGTGTCTGAACTGAAAAAAAATCCTTCGGCTGTCCTGAACGGCGCACA
GGGTGGTGCGGTTGCGGTGCTCAATCACAACCGGGTCATGGGCTATATGGTCCCGGCCGACGTGTTTGAAGCCATGATGG
AGCGTCTTGACGATCTTGAACTGGCGGAGATTGTCCGTGCCCGTCGTCACGAGACCCCGGTCCCGGTAAATCTGGATGAC
TTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8A9Z863

Antitoxin

Source ID Structure
AlphaFold DB A0A554PKE4

References