Detailed information of TA system TA047216

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1617428..1618040
• Replicon: chromosome
• Accession: NZ_CP008695
• Organism: Streptococcus pyogenes strain M23ND

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: FE90_RS08200
• Protein ID: WP_038433710.1
• Coordinates: 1617705..1618040 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q5X9X9
• Locus tag: FE90_RS08195
• Protein ID: WP_002988079.1
• Coordinates: 1617428..1617715 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FE90_RS08170	1612619..1613602	-	984	WP_038433707.1	tagatose-bisphosphate aldolase	-
FE90_RS08175	1613606..1614535	-	930	WP_038433708.1	tagatose-6-phosphate kinase	-
FE90_RS08180	1614581..1615096	-	516	WP_038433709.1	galactose-6-phosphate isomerase subunit LacB	-
FE90_RS08185	1615131..1615559	-	429	WP_002982747.1	galactose-6-phosphate isomerase subunit LacA	-
FE90_RS08190	1616005..1616778	+	774	WP_002982738.1	DeoR/GlpR family DNA-binding transcription regulator	-
FE90_RS08195	1617428..1617715	+	288	WP_002988079.1	DNA-damage-inducible protein J	Antitoxin
FE90_RS08200	1617705..1618040	+	336	WP_038433710.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FE90_RS10050	1618192..1618662	+	471	WP_030127322.1	site-specific integrase	-
FE90_RS10055	1618625..1619173	+	549	WP_193789119.1	site-specific integrase	-
FE90_RS08210	1619305..1619697	-	393	WP_038433711.1	30S ribosomal protein S9	-
FE90_RS08215	1619718..1620164	-	447	WP_011018228.1	50S ribosomal protein L13	-
FE90_RS08220	1620382..1620588	-	207	WP_002982695.1	helix-turn-helix transcriptional regulator	-
FE90_RS08225	1620585..1621283	-	699	WP_011018229.1	hypothetical protein	-
FE90_RS08230	1621419..1622279	-	861	WP_002982687.1	DegV family protein	-
FE90_RS08235	1622376..1622894	-	519	WP_011889154.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-106)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13144.86 Da
• Isoelectric Point: 5.2144

>T47216 WP_038433710.1 NZ_CP008695:1617705-1618040 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVAIDYLLPTQNDYIKLFK

Nucleotide

• Length: 336 bp

>T47216 NZ_CP008695:1617705-1618040 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTACTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGCTATTGATTACTTGCTTCCTACTCAAAACGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10934.56 Da
• Isoelectric Point: 5.2318

>AT47216 WP_002988079.1 NZ_CP008695:1617428-1617715 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT47216 NZ_CP008695:1617428-1617715 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGACGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Antitoxin

• AlphaFold DB: A0A4U7GX94