47197

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2922021..2922735 Replicon chromosome
Accession NZ_CP007809
Organism Mycobacterium tuberculosis strain KIT87190

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag ER17_RS13720 Protein ID WP_003413460.1
Coordinates 2922295..2922735 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag ER17_RS13715 Protein ID WP_003413456.1
Coordinates 2922021..2922308 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ER17_RS13680 2917443..2917688 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
ER17_RS13685 2917685..2918089 + 405 WP_003413432.1 type II toxin-antitoxin system VapC family toxin -
ER17_RS13690 2918306..2918926 + 621 WP_003413441.1 DUF4178 domain-containing protein -
ER17_RS13695 2918937..2919431 + 495 WP_003413444.1 DUF2617 family protein -
ER17_RS13700 2919428..2919859 + 432 WP_003899390.1 DUF4247 domain-containing protein -
ER17_RS13705 2919884..2920342 + 459 WP_003413451.1 DUF350 domain-containing protein -
ER17_RS13710 2920339..2921910 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
ER17_RS13715 2922021..2922308 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
ER17_RS13720 2922295..2922735 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
ER17_RS13725 2922756..2923511 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
ER17_RS13730 2923644..2924240 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
ER17_RS13735 2924248..2925093 - 846 WP_003413466.1 acyl-CoA thioesterase II -
ER17_RS13740 2925122..2926021 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
ER17_RS13745 2926149..2926823 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T47197 WP_003413460.1 NZ_CP007809:2922295-2922735 [Mycobacterium tuberculosis]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T47197 NZ_CP007809:2922295-2922735 [Mycobacterium tuberculosis]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT47197 WP_003413456.1 NZ_CP007809:2922021-2922308 [Mycobacterium tuberculosis]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT47197 NZ_CP007809:2922021-2922308 [Mycobacterium tuberculosis]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References