Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/LOTUS_5_Limkain_b1(toxin) |
Location | 2860558..2861189 | Replicon | chromosome |
Accession | NZ_CP007809 | ||
Organism | Mycobacterium tuberculosis strain KIT87190 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | G0TQ28 |
Locus tag | ER17_RS13445 | Protein ID | WP_003413174.1 |
Coordinates | 2860812..2861189 (+) | Length | 126 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | P95006 |
Locus tag | ER17_RS13440 | Protein ID | WP_003413167.1 |
Coordinates | 2860558..2860815 (+) | Length | 86 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
ER17_RS13415 | 2855792..2856997 | - | 1206 | WP_003413027.1 | chorismate synthase | - |
ER17_RS13420 | 2857105..2857419 | + | 315 | WP_009937839.1 | hypothetical protein | - |
ER17_RS13425 | 2857715..2858926 | + | 1212 | WP_003900845.1 | alpha/beta hydrolase family protein | - |
ER17_RS13430 | 2859053..2859739 | + | 687 | WP_038436266.1 | hypothetical protein | - |
ER17_RS22340 | 2859736..2860013 | + | 278 | Protein_2632 | type II toxin-antitoxin system VapB family antitoxin | - |
ER17_RS13435 | 2860106..2860519 | + | 414 | WP_003413164.1 | PIN domain nuclease | - |
ER17_RS13440 | 2860558..2860815 | + | 258 | WP_003413167.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
ER17_RS13445 | 2860812..2861189 | + | 378 | WP_003413174.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
ER17_RS13450 | 2861205..2861579 | - | 375 | WP_003413177.1 | hypothetical protein | - |
ER17_RS13455 | 2861679..2862074 | - | 396 | WP_003413180.1 | type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 | - |
ER17_RS13460 | 2862071..2862316 | - | 246 | WP_003413183.1 | type II toxin-antitoxin system antitoxin VapB20 | - |
ER17_RS13465 | 2862727..2863146 | - | 420 | WP_003413190.1 | A24 family peptidase | - |
ER17_RS13470 | 2863158..2863967 | - | 810 | WP_003413193.1 | shikimate dehydrogenase | - |
ER17_RS13475 | 2863964..2865217 | - | 1254 | WP_003413196.1 | endolytic transglycosylase MltG | - |
ER17_RS13480 | 2865210..2865722 | - | 513 | WP_003413197.1 | Holliday junction resolvase RuvX | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 13728.72 Da Isoelectric Point: 4.4687
>T47195 WP_003413174.1 NZ_CP007809:2860812-2861189 [Mycobacterium tuberculosis]
VKLIDTTIAVDHLRGEPAAAVLLAELINNGEEIAASELVRFELLAGVRESELAALEAFFSAVVWTLVTEDIARIGGRLAR
RYRSSHRGIDDVDYLIAATAIVVDADLLTTNVRHFPMFPDLQPPY
VKLIDTTIAVDHLRGEPAAAVLLAELINNGEEIAASELVRFELLAGVRESELAALEAFFSAVVWTLVTEDIARIGGRLAR
RYRSSHRGIDDVDYLIAATAIVVDADLLTTNVRHFPMFPDLQPPY
Download Length: 378 bp
>T47195 NZ_CP007809:2860812-2861189 [Mycobacterium tuberculosis]
GTGAAGCTGATCGACACCACCATCGCGGTCGACCACCTTCGCGGCGAACCCGCGGCAGCCGTGCTGCTCGCCGAACTGAT
AAACAACGGTGAGGAGATCGCGGCCAGCGAGCTGGTCCGATTCGAACTCCTCGCCGGTGTGCGGGAAAGCGAACTCGCGG
CGCTCGAGGCCTTCTTCTCGGCAGTGGTGTGGACCCTGGTGACCGAGGACATTGCCCGGATCGGCGGACGACTCGCCCGT
CGATACCGGTCCAGCCACCGCGGTATCGACGACGTGGACTACCTGATCGCTGCGACCGCCATTGTGGTCGACGCCGACCT
GCTCACCACCAATGTGCGCCACTTCCCGATGTTCCCGGATCTGCAGCCGCCGTACTGA
GTGAAGCTGATCGACACCACCATCGCGGTCGACCACCTTCGCGGCGAACCCGCGGCAGCCGTGCTGCTCGCCGAACTGAT
AAACAACGGTGAGGAGATCGCGGCCAGCGAGCTGGTCCGATTCGAACTCCTCGCCGGTGTGCGGGAAAGCGAACTCGCGG
CGCTCGAGGCCTTCTTCTCGGCAGTGGTGTGGACCCTGGTGACCGAGGACATTGCCCGGATCGGCGGACGACTCGCCCGT
CGATACCGGTCCAGCCACCGCGGTATCGACGACGTGGACTACCTGATCGCTGCGACCGCCATTGTGGTCGACGCCGACCT
GCTCACCACCAATGTGCGCCACTTCCCGATGTTCCCGGATCTGCAGCCGCCGTACTGA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9453.63 Da Isoelectric Point: 10.6555
>AT47195 WP_003413167.1 NZ_CP007809:2860558-2860815 [Mycobacterium tuberculosis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA
Download Length: 258 bp
>AT47195 NZ_CP007809:2860558-2860815 [Mycobacterium tuberculosis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | G0TQ28 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829C9W5 |