Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1273370..1273959 Replicon chromosome
Accession NZ_CP007805
Organism Haemophilus influenzae CGSHiCZ412602

Toxin (Protein)


Gene name hicA Uniprot ID Q4QL51
Locus tag H733_RS06160 Protein ID WP_005653200.1
Coordinates 1273711..1273959 (-) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q4QL50
Locus tag H733_RS06155 Protein ID WP_005653201.1
Coordinates 1273370..1273714 (-) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H733_RS06140 1268597..1269991 - 1395 WP_038439957.1 sodium-coupled multidrug efflux MATE transporter HmrM -
H733_RS06145 1270035..1270649 + 615 WP_005647294.1 riboflavin synthase -
H733_RS06150 1270717..1273326 - 2610 WP_038439959.1 aminopeptidase N -
H733_RS06155 1273370..1273714 - 345 WP_005653201.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
H733_RS06160 1273711..1273959 - 249 WP_005653200.1 type II toxin-antitoxin system HicA family toxin Toxin
H733_RS06165 1274378..1274872 + 495 WP_005664624.1 5-(carboxyamino)imidazole ribonucleotide mutase -
H733_RS06170 1274942..1276030 + 1089 WP_038439960.1 5-(carboxyamino)imidazole ribonucleotide synthase -
H733_RS06175 1276170..1277360 + 1191 WP_038439961.1 aspartate/tyrosine/aromatic aminotransferase -
H733_RS06180 1277465..1278091 - 627 WP_005671598.1 energy-coupling factor ABC transporter ATP-binding protein -
H733_RS06185 1278093..1278725 - 633 WP_032824077.1 energy-coupling factor transporter transmembrane protein EcfT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-81)

Antitoxin

Uncharacterised protein family HicB

(54-102)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9425.93 Da        Isoelectric Point: 10.4673

>T47149 WP_005653200.1 NZ_CP007805:c1273959-1273711 [Haemophilus influenzae CGSHiCZ412602]
MGRTEKLLDKLAQSKSTFNWNELVSLLAQQGYEKREMAGSRVRFYNRTLEHTILLHKPHPENYIKGGALKSVKESLKQVG
IL

Download         Length: 249 bp

>T47149 NZ_CP007805:c1273959-1273711 [Haemophilus influenzae CGSHiCZ412602]
ATGGGACGAACTGAAAAATTATTAGATAAGCTCGCACAATCAAAATCTACATTTAATTGGAATGAATTAGTTTCTTTGTT
AGCTCAACAAGGTTATGAAAAGCGAGAAATGGCAGGCTCTCGAGTGAGATTTTATAATAGAACACTCGAACATACGATTT
TGTTACACAAGCCCCACCCTGAAAATTATATTAAAGGCGGTGCTTTAAAGTCAGTGAAAGAATCATTAAAACAGGTAGGT
ATTCTATGA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 13142.04 Da        Isoelectric Point: 4.8151

>AT47149 WP_005653201.1 NZ_CP007805:c1273714-1273370 [Haemophilus influenzae CGSHiCZ412602]
MKLLNYKGYVGTIEADLENNILFGKLAYIRDLVTYEAESLSELEKEFRQSVDLYLQDCLELGKEPNKPFKGVFNVRIGEE
LHREATIIAGDRSLNAFVTEAIQEKIFREKPSLR

Download         Length: 345 bp

>AT47149 NZ_CP007805:c1273714-1273370 [Haemophilus influenzae CGSHiCZ412602]
ATGAAGTTATTAAATTATAAAGGTTATGTTGGCACGATTGAGGCGGATTTAGAAAACAATATATTATTTGGCAAACTTGC
TTACATTCGTGATTTAGTGACTTACGAAGCAGAGTCATTATCTGAGCTAGAAAAAGAATTTCGTCAATCTGTTGATTTAT
ATTTACAAGATTGTTTGGAATTAGGTAAAGAACCGAATAAGCCTTTTAAAGGTGTATTTAATGTACGAATTGGCGAGGAA
TTGCATAGAGAAGCTACGATCATAGCAGGCGATCGTTCTCTTAATGCTTTTGTTACGGAAGCGATTCAAGAAAAAATTTT
TCGTGAAAAACCAAGTTTAAGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5M6BP03

Antitoxin

Source ID Structure
AlphaFold DB A0A0M1GMF9

References