Detailed information of TA system TA047146

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): toxTA/Tad-couple_hipB
• Location: 576714..577224
• Replicon: chromosome
• Accession: NZ_CP007805
• Organism: Haemophilus influenzae CGSHiCZ412602

Toxin (Protein)

• Gene name: toxT
• Uniprot ID: A0A2S9R6L1
• Locus tag: H733_RS02875
• Protein ID: WP_038439526.1
• Coordinates: 577003..577224 (-)
• Length: 74 a.a.

Antitoxin (Protein)

• Gene name: toxA
• Uniprot ID: -
• Locus tag: H733_RS02870
• Protein ID: WP_005650837.1
• Coordinates: 576714..577010 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H733_RS02845	571914..572477	-	564	WP_038439521.1	DNA-3-methyladenine glycosylase I	-
H733_RS02850	572691..573497	-	807	WP_038439522.1	shikimate dehydrogenase	-
H733_RS02855	573501..574052	-	552	WP_038439523.1	Sua5/YciO/YrdC/YwlC family protein	-
H733_RS02860	574068..574604	-	537	WP_038439524.1	topoisomerase DNA-binding C4 zinc finger domain-containing protein	-
H733_RS02865	574614..576530	-	1917	WP_038439525.1	ABC transporter ATP-binding protein	-
H733_RS02870	576714..577010	-	297	WP_005650837.1	helix-turn-helix transcriptional regulator	Antitoxin
H733_RS02875	577003..577224	-	222	WP_038439526.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
H733_RS02880	577331..580366	-	3036	WP_038439528.1	TonB-dependent hemoglobin/transferrin/lactoferrin family receptor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (10-63)

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-89)

Sequences

Toxin

Protein

• Length: 74 a.a.
• Molecular weight: 8804.33 Da
• Isoelectric Point: 10.7588

>T47146 WP_038439526.1 NZ_CP007805:c577224-577003 [Haemophilus influenzae CGSHiCZ412602]
VQNLLENQALFAILDGEIWELRPIRDRILFARLMDGRFVLLHQFMKKTQKTPKREIQTAQQRLSELKERLKNE

Nucleotide

• Length: 222 bp

>T47146 NZ_CP007805:c577224-577003 [Haemophilus influenzae CGSHiCZ412602]
GTGCAAAATCTCCTTGAAAATCAAGCTCTTTTTGCTATTTTAGACGGTGAAATTTGGGAACTTCGCCCAATTAGGGATCG
CATCTTGTTTGCAAGATTAATGGACGGTCGCTTTGTCTTACTACATCAATTTATGAAGAAAACACAAAAAACGCCAAAAC
GAGAAATCCAAACAGCCCAACAACGCTTAAGTGAATTAAAAGAGAGATTGAAAAATGAATAA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11092.94 Da
• Isoelectric Point: 10.3139

>AT47146 WP_005650837.1 NZ_CP007805:c577010-576714 [Haemophilus influenzae CGSHiCZ412602]
MNKISPLGSNWNEFEQQIFNEEEIRESNLRVALIKELITSRQQLGISQKQLETLSGVKQPMIARIEKGQTNPQLETLLKL
LAPLGKTLSIVPLRVKNA

Nucleotide

• Length: 297 bp

>AT47146 NZ_CP007805:c577010-576714 [Haemophilus influenzae CGSHiCZ412602]
ATGAATAAAATCAGCCCATTAGGTTCAAATTGGAATGAGTTTGAACAGCAAATTTTCAATGAAGAAGAAATCCGCGAAAG
TAATTTGCGTGTAGCCTTAATTAAAGAATTGATTACTTCTCGCCAGCAACTTGGGATTTCCCAAAAACAACTTGAAACCT
TAAGCGGTGTGAAGCAACCTATGATTGCACGCATTGAAAAAGGACAAACGAATCCTCAACTTGAAACGTTGTTAAAATTG
CTCGCTCCTTTAGGGAAAACCCTGTCGATTGTGCCTCTAAGGGTAAAAAATGCCTAA

Structures

Toxin

• AlphaFold DB: A0A2S9R6L1