Detailed information of TA system TA047145

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 236096..236733
• Replicon: chromosome
• Accession: NZ_CP007805
• Organism: Haemophilus influenzae CGSHiCZ412602

Toxin (Protein)

• Gene name: VapC1
• Uniprot ID: -
• Locus tag: H733_RS01140
• Protein ID: WP_038439256.1
• Coordinates: 236329..236733 (+)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: VapB1
• Uniprot ID: A0A0H3PN67
• Locus tag: H733_RS01135
• Protein ID: WP_005656316.1
• Coordinates: 236096..236332 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H733_RS01110	231474..232214	-	741	WP_005649034.1	YebC/PmpR family DNA-binding transcriptional regulator	-
H733_RS01115	232226..232699	-	474	WP_038439249.1	dihydroneopterin triphosphate diphosphatase	-
H733_RS01120	232721..234487	-	1767	WP_038439250.1	aspartate--tRNA ligase	-
H733_RS01125	234707..235225	+	519	WP_038439252.1	isoprenylcysteine carboxyl methyltransferase family protein	-
H733_RS01130	235278..236003	+	726	WP_038439255.1	carboxy-S-adenosyl-L-methionine synthase CmoA	-
H733_RS01135	236096..236332	+	237	WP_005656316.1	antitoxin	Antitoxin
H733_RS01140	236329..236733	+	405	WP_038439256.1	type II toxin-antitoxin system VapC family toxin	Toxin
H733_RS01145	236800..237207	+	408	WP_005628548.1	lactoylglutathione lyase	-
H733_RS01150	237281..237970	+	690	WP_005659978.1	ribonuclease T	-
H733_RS01155	238284..239636	+	1353	WP_038439259.1	Na+/H+ antiporter family protein	-
H733_RS01160	239669..240256	+	588	WP_038439260.1	primosomal replication protein	-
H733_RS01170	240612..241178	-	567	WP_005662944.1	elongation factor P	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-124)

Antitoxin

• SpoVT-AbrB domain (6-44)

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 15637.21 Da
• Isoelectric Point: 8.4636

>T47145 WP_038439256.1 NZ_CP007805:236329-236733 [Haemophilus influenzae CGSHiCZ412602]
MIYMLDTNIIIYLMKNRPKIVAERVSQLLPNDRLVMSFITYAELIKGAFGSQNYEQSIRAIELLTERVNVLYPNEQICLH
YGKWASTLKKQGQPIGNNDLWIACHALSLNAVLITHNIKEFQRITDLQWQDWTK

Nucleotide

• Length: 405 bp

>T47145 NZ_CP007805:236329-236733 [Haemophilus influenzae CGSHiCZ412602]
ATGATTTATATGTTAGACACTAATATCATTATTTATTTAATGAAAAATCGTCCCAAAATTGTTGCCGAACGAGTATCACA
ATTATTGCCTAATGATCGCTTAGTTATGAGCTTTATTACTTATGCTGAACTTATTAAAGGCGCGTTTGGTAGTCAAAATT
ATGAGCAATCAATACGAGCAATAGAATTGCTTACTGAGCGAGTGAATGTACTATATCCCAATGAACAAATCTGTTTACAT
TATGGCAAATGGGCAAGTACACTCAAAAAACAGGGGCAACCTATCGGAAATAATGACCTATGGATTGCTTGCCACGCATT
GAGTTTAAATGCTGTTCTTATTACACATAATATAAAAGAGTTTCAGCGTATTACAGATCTTCAATGGCAAGATTGGACAA
AATAG

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 9007.16 Da
• Isoelectric Point: 4.2342

>AT47145 WP_005656316.1 NZ_CP007805:236096-236332 [Haemophilus influenzae CGSHiCZ412602]
MLAKVFQSGNSQAVRIPMDFRFDVDTVEIFRKENGDVVLRPVSKKTDDFLALFEGFDETFIQALEARDDLPPQERENL

Nucleotide

• Length: 237 bp

>AT47145 NZ_CP007805:236096-236332 [Haemophilus influenzae CGSHiCZ412602]
ATGCTTGCTAAAGTGTTTCAAAGTGGTAACAGCCAAGCTGTTCGGATCCCGATGGACTTTCGTTTTGATGTCGATACCGT
AGAAATTTTCCGAAAGGAAAATGGAGATGTGGTATTACGCCCAGTTTCTAAAAAAACAGATGATTTTCTTGCGTTATTTG
AAGGATTTGATGAGACCTTTATTCAAGCACTTGAAGCGCGTGATGATTTACCGCCTCAGGAGCGAGAAAATTTATGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3PN67