Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3685239..3685913 Replicon chromosome
Accession NZ_CP007803
Organism Mycobacterium tuberculosis K

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag MTBK_RS17395 Protein ID WP_003417282.1
Coordinates 3685239..3685667 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag MTBK_RS17400 Protein ID WP_003417286.1
Coordinates 3685671..3685913 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTBK_RS17370 3681061..3681462 - 402 WP_003417264.1 cytidine deaminase -
MTBK_RS17375 3681603..3682037 + 435 WP_003900017.1 succinate dehydrogenase, cytochrome b556 subunit -
MTBK_RS17380 3682034..3682468 + 435 WP_003902441.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
MTBK_RS17385 3682597..3684369 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
MTBK_RS17390 3684369..3685160 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
MTBK_RS17395 3685239..3685667 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
MTBK_RS17400 3685671..3685913 - 243 WP_003417286.1 ribbon-helix-helix domain-containing protein Antitoxin
MTBK_RS17405 3686035..3686649 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
MTBK_RS17410 3686646..3687311 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
MTBK_RS17415 3687312..3687845 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
MTBK_RS17420 3687842..3688216 - 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -
MTBK_RS17425 3688313..3689377 - 1065 WP_003913037.1 GTP 3',8-cyclase MoaA -
MTBK_RS22460 3690022..3690240 + 219 WP_016810323.1 hypothetical protein -
MTBK_RS17440 3690181..3690563 - 383 Protein_3439 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T47141 WP_003417282.1 NZ_CP007803:c3685667-3685239 [Mycobacterium tuberculosis K]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T47141 NZ_CP007803:c3685667-3685239 [Mycobacterium tuberculosis K]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT47141 WP_003417286.1 NZ_CP007803:c3685913-3685671 [Mycobacterium tuberculosis K]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT47141 NZ_CP007803:c3685913-3685671 [Mycobacterium tuberculosis K]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References