Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/PIN(toxin) |
Location | 3685239..3685913 | Replicon | chromosome |
Accession | NZ_CP007803 | ||
Organism | Mycobacterium tuberculosis K |
Toxin (Protein)
Gene name | vapC | Uniprot ID | P9WF52 |
Locus tag | MTBK_RS17395 | Protein ID | WP_003417282.1 |
Coordinates | 3685239..3685667 (-) | Length | 143 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | G0TI59 |
Locus tag | MTBK_RS17400 | Protein ID | WP_003417286.1 |
Coordinates | 3685671..3685913 (-) | Length | 81 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MTBK_RS17370 | 3681061..3681462 | - | 402 | WP_003417264.1 | cytidine deaminase | - |
MTBK_RS17375 | 3681603..3682037 | + | 435 | WP_003900017.1 | succinate dehydrogenase, cytochrome b556 subunit | - |
MTBK_RS17380 | 3682034..3682468 | + | 435 | WP_003902441.1 | succinate dehydrogenase hydrophobic membrane anchor subunit | - |
MTBK_RS17385 | 3682597..3684369 | + | 1773 | WP_003417273.1 | succinate dehydrogenase flavoprotein subunit | - |
MTBK_RS17390 | 3684369..3685160 | + | 792 | WP_003417279.1 | succinate dehydrogenase iron-sulfur subunit | - |
MTBK_RS17395 | 3685239..3685667 | - | 429 | WP_003417282.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
MTBK_RS17400 | 3685671..3685913 | - | 243 | WP_003417286.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
MTBK_RS17405 | 3686035..3686649 | - | 615 | WP_003417288.1 | class I SAM-dependent methyltransferase | - |
MTBK_RS17410 | 3686646..3687311 | - | 666 | WP_003417290.1 | molybdopterin converting factor subunit 1 | - |
MTBK_RS17415 | 3687312..3687845 | - | 534 | WP_003417293.1 | cyclic pyranopterin monophosphate synthase MoaC | - |
MTBK_RS17420 | 3687842..3688216 | - | 375 | WP_003417295.1 | 4a-hydroxytetrahydrobiopterin dehydratase | - |
MTBK_RS17425 | 3688313..3689377 | - | 1065 | WP_003913037.1 | GTP 3',8-cyclase MoaA | - |
MTBK_RS22460 | 3690022..3690240 | + | 219 | WP_016810323.1 | hypothetical protein | - |
MTBK_RS17440 | 3690181..3690563 | - | 383 | Protein_3439 | transposase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 143 a.a. Molecular weight: 15834.16 Da Isoelectric Point: 8.5471
>T47141 WP_003417282.1 NZ_CP007803:c3685667-3685239 [Mycobacterium tuberculosis K]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL
Download Length: 429 bp
>T47141 NZ_CP007803:c3685667-3685239 [Mycobacterium tuberculosis K]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG
Antitoxin
Download Length: 81 a.a. Molecular weight: 8849.86 Da Isoelectric Point: 5.1007
>AT47141 WP_003417286.1 NZ_CP007803:c3685913-3685671 [Mycobacterium tuberculosis K]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV
Download Length: 243 bp
>AT47141 NZ_CP007803:c3685913-3685671 [Mycobacterium tuberculosis K]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U4FBL0 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | G0TI59 |