Detailed information of TA system TA047137

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN_Sll0205-like-Phd
• Location: 3111724..3112328
• Replicon: chromosome
• Accession: NZ_CP007803
• Organism: Mycobacterium tuberculosis K

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: P71623
• Locus tag: MTBK_RS14795
• Protein ID: WP_003414492.1
• Coordinates: 3111724..3112116 (-)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A829CBY8
• Locus tag: MTBK_RS14800
• Protein ID: WP_003414495.1
• Coordinates: 3112113..3112328 (-)
• Length: 72 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MTBK_RS14765	3106874..3107596	-	723	WP_003912014.1	CRISPR-associated endoribonuclease Cas6	-
MTBK_RS14770	3107996..3108541	-	546	WP_014584866.1	DUF1802 family protein	-
MTBK_RS14775	3108813..3109697	-	885	WP_003414409.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
MTBK_RS14780	3109700..3110587	-	888	WP_003414414.1	type IV toxin-antitoxin system AbiEi family antitoxin	-
MTBK_RS14785	3110892..3111437	-	546	WP_003899500.1	DUF1802 family protein	-
MTBK_RS14790	3111434..3111703	-	270	WP_003414489.1	DUF2277 family protein	-
MTBK_RS14795	3111724..3112116	-	393	WP_003414492.1	type II toxin-antitoxin system VapC family toxin	Toxin
MTBK_RS14800	3112113..3112328	-	216	WP_003414495.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MTBK_RS14805	3112375..3113124	+	750	WP_003902358.1	enoyl-CoA hydratase	-
MTBK_RS14810	3113203..3114285	-	1083	WP_003414499.1	ABC transporter ATP-binding protein	-
MTBK_RS14815	3114278..3115588	-	1311	WP_003414501.1	ABC transporter substrate-binding protein	-
MTBK_RS14820	3115591..3116418	-	828	WP_003414504.1	carbohydrate ABC transporter permease	-
MTBK_RS14825	3116415..3117326	-	912	WP_003902360.1	sugar ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• VapC-like Sll0205 protein, PIN domain (5-130)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-46)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 14610.74 Da
• Isoelectric Point: 6.7594

>T47137 WP_003414492.1 NZ_CP007803:c3112116-3111724 [Mycobacterium tuberculosis K]
MTTVLLDSHVAYWWSAEPQRLSMAASQAIEHADELAVAAISWFELAWLAEQERIQLAIPVLSWLQQLAEHVRTVGITPSV
AATAVALPSSFPGDPADRLIYATAIEHGWRLVTKDRRLRSHRHPRPVTVW

Nucleotide

• Length: 393 bp

>T47137 NZ_CP007803:c3112116-3111724 [Mycobacterium tuberculosis K]
ATGACGACGGTGCTGCTCGACTCGCATGTGGCCTACTGGTGGTCGGCCGAGCCGCAGCGTCTCAGCATGGCGGCGAGCCA
GGCCATCGAACACGCCGACGAGCTCGCCGTCGCCGCGATTTCGTGGTTCGAGCTGGCTTGGCTTGCCGAACAGGAACGCA
TCCAACTGGCGATTCCGGTGCTGTCCTGGCTTCAGCAGCTGGCCGAGCACGTTCGCACCGTCGGTATCACGCCCTCGGTC
GCCGCCACGGCGGTGGCGCTGCCCTCGTCGTTCCCCGGCGATCCGGCCGACCGGTTGATCTACGCCACCGCGATCGAACA
CGGCTGGCGGCTGGTGACCAAGGACCGGCGGCTACGCAGTCATCGGCACCCACGACCGGTCACCGTCTGGTAG

Antitoxin

Protein

• Length: 72 a.a.
• Molecular weight: 7511.55 Da
• Isoelectric Point: 4.9732

>AT47137 WP_003414495.1 NZ_CP007803:c3112328-3112113 [Mycobacterium tuberculosis K]
MTATEVKAKILSLLDEVAQGEEIEITKHGRTVARLVAATGPHALKGRFSGVAMAAVDDDELFTTGVSWNVS

Nucleotide

• Length: 216 bp

>AT47137 NZ_CP007803:c3112328-3112113 [Mycobacterium tuberculosis K]
ATGACCGCTACGGAGGTGAAGGCGAAGATCCTCTCCTTGCTTGATGAAGTGGCCCAGGGCGAGGAGATCGAGATCACCAA
ACACGGCCGCACCGTGGCCCGGCTGGTGGCAGCGACGGGGCCGCACGCGCTGAAGGGTCGATTCTCGGGTGTGGCGATGG
CGGCCGTGGATGACGACGAACTCTTCACCACCGGGGTTTCGTGGAACGTTTCATGA

Structures

Toxin

• AlphaFold DB: A0A7U4BWM8

Antitoxin

• AlphaFold DB: A0A829CBY8