Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | parDE/- |
Location | 2385555..2386084 | Replicon | chromosome |
Accession | NZ_CP007803 | ||
Organism | Mycobacterium tuberculosis K |
Toxin (Protein)
Gene name | parE | Uniprot ID | G0TMR4 |
Locus tag | MTBK_RS11180 | Protein ID | WP_003411124.1 |
Coordinates | 2385555..2385872 (-) | Length | 106 a.a. |
Antitoxin (Protein)
Gene name | parD | Uniprot ID | P9WJ74 |
Locus tag | MTBK_RS11185 | Protein ID | WP_003411127.1 |
Coordinates | 2385869..2386084 (-) | Length | 72 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MTBK_RS11150 | 2380576..2381652 | + | 1077 | WP_003411110.1 | hypothetical protein | - |
MTBK_RS11155 | 2381649..2381930 | + | 282 | WP_003411112.1 | hypothetical protein | - |
MTBK_RS11160 | 2381966..2383039 | + | 1074 | WP_003901338.1 | quinone-dependent dihydroorotate dehydrogenase | - |
MTBK_RS11165 | 2383044..2383574 | - | 531 | WP_003411119.1 | YbhB/YbcL family Raf kinase inhibitor-like protein | - |
MTBK_RS11170 | 2383622..2384968 | - | 1347 | WP_003411121.1 | M20/M25/M40 family metallo-hydrolase | - |
MTBK_RS11180 | 2385555..2385872 | - | 318 | WP_003411124.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
MTBK_RS11185 | 2385869..2386084 | - | 216 | WP_003411127.1 | antitoxin ParD2 | Antitoxin |
MTBK_RS11190 | 2386339..2387397 | + | 1059 | WP_003411129.1 | hypothetical protein | - |
MTBK_RS11195 | 2387527..2387883 | - | 357 | WP_003411130.1 | hypothetical protein | - |
MTBK_RS11200 | 2387978..2388760 | - | 783 | WP_003411131.1 | cell wall synthesis protein Wag31 | - |
MTBK_RS11205 | 2389028..2389318 | - | 291 | WP_003900476.1 | YggT family protein | - |
MTBK_RS11210 | 2389480..2390136 | - | 657 | WP_003411133.1 | cell division protein SepF | - |
MTBK_RS11215 | 2390202..2390978 | - | 777 | WP_003411137.1 | YggS family pyridoxal phosphate-dependent enzyme | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 106 a.a. Molecular weight: 12312.88 Da Isoelectric Point: 6.4831
>T47125 WP_003411124.1 NZ_CP007803:c2385872-2385555 [Mycobacterium tuberculosis K]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE
Download Length: 318 bp
>T47125 NZ_CP007803:c2385872-2385555 [Mycobacterium tuberculosis K]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA
Antitoxin
Download Length: 72 a.a. Molecular weight: 7880.70 Da Isoelectric Point: 4.4055
>AT47125 WP_003411127.1 NZ_CP007803:c2386084-2385869 [Mycobacterium tuberculosis K]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG
Download Length: 216 bp
>AT47125 NZ_CP007803:c2386084-2385869 [Mycobacterium tuberculosis K]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | G0TMR4 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U4FAJ4 |