Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2385555..2386084 Replicon chromosome
Accession NZ_CP007803
Organism Mycobacterium tuberculosis K

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag MTBK_RS11180 Protein ID WP_003411124.1
Coordinates 2385555..2385872 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag MTBK_RS11185 Protein ID WP_003411127.1
Coordinates 2385869..2386084 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTBK_RS11150 2380576..2381652 + 1077 WP_003411110.1 hypothetical protein -
MTBK_RS11155 2381649..2381930 + 282 WP_003411112.1 hypothetical protein -
MTBK_RS11160 2381966..2383039 + 1074 WP_003901338.1 quinone-dependent dihydroorotate dehydrogenase -
MTBK_RS11165 2383044..2383574 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
MTBK_RS11170 2383622..2384968 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
MTBK_RS11180 2385555..2385872 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MTBK_RS11185 2385869..2386084 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
MTBK_RS11190 2386339..2387397 + 1059 WP_003411129.1 hypothetical protein -
MTBK_RS11195 2387527..2387883 - 357 WP_003411130.1 hypothetical protein -
MTBK_RS11200 2387978..2388760 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
MTBK_RS11205 2389028..2389318 - 291 WP_003900476.1 YggT family protein -
MTBK_RS11210 2389480..2390136 - 657 WP_003411133.1 cell division protein SepF -
MTBK_RS11215 2390202..2390978 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T47125 WP_003411124.1 NZ_CP007803:c2385872-2385555 [Mycobacterium tuberculosis K]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T47125 NZ_CP007803:c2385872-2385555 [Mycobacterium tuberculosis K]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT47125 WP_003411127.1 NZ_CP007803:c2386084-2385869 [Mycobacterium tuberculosis K]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT47125 NZ_CP007803:c2386084-2385869 [Mycobacterium tuberculosis K]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References