Detailed information of TA system TA047124

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 2348673..2349368
• Replicon: chromosome
• Accession: NZ_CP007803
• Organism: Mycobacterium tuberculosis K

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: O53501
• Locus tag: MTBK_RS10965
• Protein ID: WP_003410811.1
• Coordinates: 2348673..2349107 (-)
• Length: 145 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: MTBK_RS10970
• Protein ID: WP_003902124.1
• Coordinates: 2349114..2349368 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MTBK_RS10955	2344827..2347868	+	3042	WP_003899171.1	DEAD/DEAH box helicase	-
MTBK_RS10960	2347978..2348694	+	717	WP_003410793.1	SWIM zinc finger family protein	-
MTBK_RS10965	2348673..2349107	-	435	WP_003410811.1	type II toxin-antitoxin system VapC family toxin	Toxin
MTBK_RS10970	2349114..2349368	-	255	WP_003902124.1	antitoxin	Antitoxin
MTBK_RS10975	2349384..2349641	-	258	WP_003410816.1	hypothetical protein	-
MTBK_RS10980	2350588..2350884	+	297	WP_003410820.1	PE family protein	-
MTBK_RS10985	2350940..2351671	+	732	WP_003900467.1	PPE family protein	-
MTBK_RS10990	2352211..2352957	-	747	WP_003901330.1	proteasome subunit alpha	-
MTBK_RS10995	2352954..2353829	-	876	WP_003411023.1	proteasome subunit beta	-
MTBK_RS11000	2353826..2354020	-	195	WP_003411026.1	ubiquitin-like protein Pup	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (1-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 145 a.a.
• Molecular weight: 15662.08 Da
• Isoelectric Point: 7.4681

>T47124 WP_003410811.1 NZ_CP007803:c2349107-2348673 [Mycobacterium tuberculosis K]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Nucleotide

• Length: 435 bp

>T47124 NZ_CP007803:c2349107-2348673 [Mycobacterium tuberculosis K]
ATGAAGATCGTCGACGCGAACGTCTTGCTCTACGCCGTGAACACCACAAGTGAGCACCACAAGCCGTCGCTGCGCTGGCT
TGACGGTGCGCTGTCGGGCGCCGACCGCGTCGGGTTCGCCTGGGTGCCGTTGTTGGCGTTCGTGCGATTGGCGACCAAGG
TGGGGTTGTTCCCCCGTCCGCTTCCGCGGGAGGCGGCCATCACCCAGGTCGCGGATTGGCTAGCCGCACCCAGCGCCGTC
TTGGTGAATCCGACCGTCCGGCACGCCGATATCCTGGCGAGAATGCTGACGTACGTGGGAACCGGTGCCAACCTGGTCAA
CGACGCGCATCTGGCCGCGCTTGCCGTCGAGCATCGCGCCAGCATCGTGTCCTACGACAGTGACTTCGGCCGATTCGAAG
GGGTGCGCTGGGATCAGCCGCCCGCGCTGTTGTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9403.54 Da
• Isoelectric Point: 8.9912

>AT47124 WP_003902124.1 NZ_CP007803:c2349368-2349114 [Mycobacterium tuberculosis K]
MRTTVSLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Nucleotide

• Length: 255 bp

>AT47124 NZ_CP007803:c2349368-2349114 [Mycobacterium tuberculosis K]
ATGCGGACGACTGTCTCATTGGATGACGACGTCGAGCAGTTGGTAAGGCGCCGGATGGCCGAGCGGCAAGTGTCCTTCAA
GAAGGCCCTCAACGACGCGATTCGCGACGGCGCCTCCGGGCGACCTGCGCCGAGTCACTTCAGCACCCGCACGGCAGACT
TGGGCGTCCCTGCGGTCAACCTCGACCGGGCCTTGCAGCTTGCGGCCGACCTCGAGGACGAAGAGCTTGTGCGCCGTCAA
CGCCGCGGGTCATAG

Structures

Toxin

• AlphaFold DB: A0A7U4FB09