Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC(toxin) |
Location | 1949086..1949546 | Replicon | chromosome |
Accession | NZ_CP007803 | ||
Organism | Mycobacterium tuberculosis K |
Toxin (Protein)
Gene name | vapC | Uniprot ID | G0TKL9 |
Locus tag | MTBK_RS09055 | Protein ID | WP_003898996.1 |
Coordinates | 1949298..1949546 (+) | Length | 83 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | P9WJ30 |
Locus tag | MTBK_RS09050 | Protein ID | WP_003408528.1 |
Coordinates | 1949086..1949298 (+) | Length | 71 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MTBK_RS09035 | 1945564..1946751 | - | 1188 | WP_003898992.1 | nitrate transporter NarK | - |
MTBK_RS09040 | 1947038..1947322 | + | 285 | WP_003408522.1 | DUF1876 domain-containing protein | - |
MTBK_RS09045 | 1947336..1949018 | - | 1683 | WP_003901239.1 | SulP family inorganic anion transporter | - |
MTBK_RS09050 | 1949086..1949298 | + | 213 | WP_003408528.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
MTBK_RS09055 | 1949298..1949546 | + | 249 | WP_003898996.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
MTBK_RS09060 | 1949554..1950291 | + | 738 | WP_003898997.1 | hypothetical protein | - |
MTBK_RS09065 | 1950385..1952085 | + | 1701 | WP_003898998.1 | serine/threonine protein kinase PknE | - |
MTBK_RS09070 | 1952370..1952771 | - | 402 | WP_003408538.1 | hypothetical protein | - |
MTBK_RS09075 | 1952761..1953372 | - | 612 | WP_003898999.1 | isopentenyl-diphosphate Delta-isomerase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 83 a.a. Molecular weight: 8884.14 Da Isoelectric Point: 4.1074
>T47114 WP_003898996.1 NZ_CP007803:1949298-1949546 [Mycobacterium tuberculosis K]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYKGDDFACIDIRAVL
AG
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYKGDDFACIDIRAVL
AG
Download Length: 249 bp
>T47114 NZ_CP007803:1949298-1949546 [Mycobacterium tuberculosis K]
ATGGTGATCGATACCTCTGCGCTGGTCGCGATGCTCAACGATGAACCCGAGGCGCAACGGTTCGAGATAGCCGTGGCAGC
AGACCACGTTTGGCTGATGTCGACGGCGTCATATCCGGAGATGGCGACCGTGATCGAAACACGCTTCGGGGAACCGGGGG
GACGTGAACCCAAGGTCAGCGGCCAGCCTCTCCTCTATAAGGGTGACGATTTCGCATGTATCGATATTCGCGCGGTTCTC
GCCGGCTGA
ATGGTGATCGATACCTCTGCGCTGGTCGCGATGCTCAACGATGAACCCGAGGCGCAACGGTTCGAGATAGCCGTGGCAGC
AGACCACGTTTGGCTGATGTCGACGGCGTCATATCCGGAGATGGCGACCGTGATCGAAACACGCTTCGGGGAACCGGGGG
GACGTGAACCCAAGGTCAGCGGCCAGCCTCTCCTCTATAAGGGTGACGATTTCGCATGTATCGATATTCGCGCGGTTCTC
GCCGGCTGA
Antitoxin
Download Length: 71 a.a. Molecular weight: 7607.80 Da Isoelectric Point: 9.3146
>AT47114 WP_003408528.1 NZ_CP007803:1949086-1949298 [Mycobacterium tuberculosis K]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA
Download Length: 213 bp
>AT47114 NZ_CP007803:1949086-1949298 [Mycobacterium tuberculosis K]
ATGGAATTGGCGGCTCGAATGGGCGAGACTTTGACACAAGCGGTCGTAGTTGCAGTGCGGGAGCAACTGGCCCGCCGGAC
CGGGCGCACCAGATCCATTTCGCTACGCGAGGAGTTGGCCGCCATTGGCCGGCGCTGCGCGGCCTTACCGGTGCTCGACA
CCCGAGCCGCGGACACGATTCTCGGCTACGACGAGCGCGGGTTGCCCGCCTGA
ATGGAATTGGCGGCTCGAATGGGCGAGACTTTGACACAAGCGGTCGTAGTTGCAGTGCGGGAGCAACTGGCCCGCCGGAC
CGGGCGCACCAGATCCATTTCGCTACGCGAGGAGTTGGCCGCCATTGGCCGGCGCTGCGCGGCCTTACCGGTGCTCGACA
CCCGAGCCGCGGACACGATTCTCGGCTACGACGAGCGCGGGTTGCCCGCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | G0TKL9 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829CFE8 |