Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1755185..1755813 Replicon chromosome
Accession NZ_CP007803
Organism Mycobacterium tuberculosis K

Toxin (Protein)


Gene name vapC Uniprot ID P64880
Locus tag MTBK_RS08205 Protein ID WP_003407786.1
Coordinates 1755409..1755813 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WLU3
Locus tag MTBK_RS08200 Protein ID WP_003407785.1
Coordinates 1755185..1755403 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTBK_RS08170 1750605..1750985 + 381 WP_003407768.1 fumarate reductase subunit C -
MTBK_RS08175 1750982..1751359 + 378 WP_003407771.1 fumarate reductase subunit FrdD -
MTBK_RS08180 1751427..1752035 + 609 WP_003902101.1 TetR/AcrR family transcriptional regulator -
MTBK_RS08185 1752174..1753367 + 1194 WP_003902102.1 MMPL family transporter -
MTBK_RS08190 1753377..1753823 + 447 WP_003407780.1 F420H(2)-dependent quinone reductase -
MTBK_RS08195 1753858..1755147 + 1290 WP_003407781.1 threonine ammonia-lyase -
MTBK_RS08200 1755185..1755403 + 219 WP_003407785.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MTBK_RS08205 1755409..1755813 + 405 WP_003407786.1 type II toxin-antitoxin system toxin ribonuclease VapC11 Toxin
MTBK_RS08210 1755830..1757572 - 1743 WP_003407788.1 malto-oligosyltrehalose trehalohydrolase -
MTBK_RS08215 1757565..1759862 - 2298 WP_003407790.1 malto-oligosyltrehalose synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(7-49)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14650.76 Da        Isoelectric Point: 5.6587

>T47112 WP_003407786.1 NZ_CP007803:1755409-1755813 [Mycobacterium tuberculosis K]
MILIDTSAWVEYFRATGSIAAVEVRRLLSEEAARIAMCEPIAMEILSGALDDNTHTTLERLVNGLPSLNVDDAIDFRAAA
GIYRAARRAGETVRSINDCLIAALAIRHGARIVHRDADFDVIARITNLQAASFR

Download         Length: 405 bp

>T47112 NZ_CP007803:1755409-1755813 [Mycobacterium tuberculosis K]
ATGATCCTCATCGACACATCGGCCTGGGTGGAGTACTTCCGTGCCACCGGATCAATCGCCGCTGTCGAAGTACGCCGGCT
GCTGTCCGAAGAAGCAGCGCGAATCGCTATGTGTGAGCCCATTGCGATGGAAATCTTGAGTGGCGCGCTCGACGACAACA
CCCACACGACGCTAGAGCGGCTCGTGAATGGCTTGCCGTCGTTGAACGTTGATGACGCGATTGACTTTCGTGCTGCCGCG
GGTATCTATCGCGCCGCCCGGCGCGCCGGCGAAACGGTTCGAAGCATCAACGACTGCCTCATAGCGGCGCTCGCGATCCG
CCACGGTGCGCGTATCGTCCACCGTGACGCCGACTTTGATGTGATTGCCCGGATTACCAACCTGCAGGCCGCATCGTTTC
GGTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8209.32 Da        Isoelectric Point: 4.5600

>AT47112 WP_003407785.1 NZ_CP007803:1755185-1755403 [Mycobacterium tuberculosis K]
VYRWCMSRTNIDIDDELAAEVMRRFGLTTKRAAVDLALRRLVGSPLSREFLLGLEGVGWEGDLDDLRSDRPD

Download         Length: 219 bp

>AT47112 NZ_CP007803:1755185-1755403 [Mycobacterium tuberculosis K]
GTGTATCGTTGGTGTATGTCGCGCACCAACATCGACATCGATGACGAACTTGCCGCCGAGGTCATGCGCAGGTTCGGTCT
GACCACCAAGAGGGCGGCGGTCGACCTTGCCCTACGACGGTTGGTCGGGTCGCCGTTGAGCCGTGAGTTTCTGCTCGGGC
TGGAAGGCGTCGGCTGGGAAGGCGACCTGGATGACTTGCGAAGCGATCGCCCAGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6A7V

Antitoxin

Source ID Structure
PDB 6A7V
AlphaFold DB P9WLU3

References