Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC-VapB |
Location | 1755185..1755813 | Replicon | chromosome |
Accession | NZ_CP007803 | ||
Organism | Mycobacterium tuberculosis K |
Toxin (Protein)
Gene name | vapC | Uniprot ID | P64880 |
Locus tag | MTBK_RS08205 | Protein ID | WP_003407786.1 |
Coordinates | 1755409..1755813 (+) | Length | 135 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | P9WLU3 |
Locus tag | MTBK_RS08200 | Protein ID | WP_003407785.1 |
Coordinates | 1755185..1755403 (+) | Length | 73 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MTBK_RS08170 | 1750605..1750985 | + | 381 | WP_003407768.1 | fumarate reductase subunit C | - |
MTBK_RS08175 | 1750982..1751359 | + | 378 | WP_003407771.1 | fumarate reductase subunit FrdD | - |
MTBK_RS08180 | 1751427..1752035 | + | 609 | WP_003902101.1 | TetR/AcrR family transcriptional regulator | - |
MTBK_RS08185 | 1752174..1753367 | + | 1194 | WP_003902102.1 | MMPL family transporter | - |
MTBK_RS08190 | 1753377..1753823 | + | 447 | WP_003407780.1 | F420H(2)-dependent quinone reductase | - |
MTBK_RS08195 | 1753858..1755147 | + | 1290 | WP_003407781.1 | threonine ammonia-lyase | - |
MTBK_RS08200 | 1755185..1755403 | + | 219 | WP_003407785.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
MTBK_RS08205 | 1755409..1755813 | + | 405 | WP_003407786.1 | type II toxin-antitoxin system toxin ribonuclease VapC11 | Toxin |
MTBK_RS08210 | 1755830..1757572 | - | 1743 | WP_003407788.1 | malto-oligosyltrehalose trehalohydrolase | - |
MTBK_RS08215 | 1757565..1759862 | - | 2298 | WP_003407790.1 | malto-oligosyltrehalose synthase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 135 a.a. Molecular weight: 14650.76 Da Isoelectric Point: 5.6587
>T47112 WP_003407786.1 NZ_CP007803:1755409-1755813 [Mycobacterium tuberculosis K]
MILIDTSAWVEYFRATGSIAAVEVRRLLSEEAARIAMCEPIAMEILSGALDDNTHTTLERLVNGLPSLNVDDAIDFRAAA
GIYRAARRAGETVRSINDCLIAALAIRHGARIVHRDADFDVIARITNLQAASFR
MILIDTSAWVEYFRATGSIAAVEVRRLLSEEAARIAMCEPIAMEILSGALDDNTHTTLERLVNGLPSLNVDDAIDFRAAA
GIYRAARRAGETVRSINDCLIAALAIRHGARIVHRDADFDVIARITNLQAASFR
Download Length: 405 bp
>T47112 NZ_CP007803:1755409-1755813 [Mycobacterium tuberculosis K]
ATGATCCTCATCGACACATCGGCCTGGGTGGAGTACTTCCGTGCCACCGGATCAATCGCCGCTGTCGAAGTACGCCGGCT
GCTGTCCGAAGAAGCAGCGCGAATCGCTATGTGTGAGCCCATTGCGATGGAAATCTTGAGTGGCGCGCTCGACGACAACA
CCCACACGACGCTAGAGCGGCTCGTGAATGGCTTGCCGTCGTTGAACGTTGATGACGCGATTGACTTTCGTGCTGCCGCG
GGTATCTATCGCGCCGCCCGGCGCGCCGGCGAAACGGTTCGAAGCATCAACGACTGCCTCATAGCGGCGCTCGCGATCCG
CCACGGTGCGCGTATCGTCCACCGTGACGCCGACTTTGATGTGATTGCCCGGATTACCAACCTGCAGGCCGCATCGTTTC
GGTGA
ATGATCCTCATCGACACATCGGCCTGGGTGGAGTACTTCCGTGCCACCGGATCAATCGCCGCTGTCGAAGTACGCCGGCT
GCTGTCCGAAGAAGCAGCGCGAATCGCTATGTGTGAGCCCATTGCGATGGAAATCTTGAGTGGCGCGCTCGACGACAACA
CCCACACGACGCTAGAGCGGCTCGTGAATGGCTTGCCGTCGTTGAACGTTGATGACGCGATTGACTTTCGTGCTGCCGCG
GGTATCTATCGCGCCGCCCGGCGCGCCGGCGAAACGGTTCGAAGCATCAACGACTGCCTCATAGCGGCGCTCGCGATCCG
CCACGGTGCGCGTATCGTCCACCGTGACGCCGACTTTGATGTGATTGCCCGGATTACCAACCTGCAGGCCGCATCGTTTC
GGTGA
Antitoxin
Download Length: 73 a.a. Molecular weight: 8209.32 Da Isoelectric Point: 4.5600
>AT47112 WP_003407785.1 NZ_CP007803:1755185-1755403 [Mycobacterium tuberculosis K]
VYRWCMSRTNIDIDDELAAEVMRRFGLTTKRAAVDLALRRLVGSPLSREFLLGLEGVGWEGDLDDLRSDRPD
VYRWCMSRTNIDIDDELAAEVMRRFGLTTKRAAVDLALRRLVGSPLSREFLLGLEGVGWEGDLDDLRSDRPD
Download Length: 219 bp
>AT47112 NZ_CP007803:1755185-1755403 [Mycobacterium tuberculosis K]
GTGTATCGTTGGTGTATGTCGCGCACCAACATCGACATCGATGACGAACTTGCCGCCGAGGTCATGCGCAGGTTCGGTCT
GACCACCAAGAGGGCGGCGGTCGACCTTGCCCTACGACGGTTGGTCGGGTCGCCGTTGAGCCGTGAGTTTCTGCTCGGGC
TGGAAGGCGTCGGCTGGGAAGGCGACCTGGATGACTTGCGAAGCGATCGCCCAGACTGA
GTGTATCGTTGGTGTATGTCGCGCACCAACATCGACATCGATGACGAACTTGCCGCCGAGGTCATGCGCAGGTTCGGTCT
GACCACCAAGAGGGCGGCGGTCGACCTTGCCCTACGACGGTTGGTCGGGTCGCCGTTGAGCCGTGAGTTTCTGCTCGGGC
TGGAAGGCGTCGGCTGGGAAGGCGACCTGGATGACTTGCGAAGCGATCGCCCAGACTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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