Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1676703..1677319 Replicon chromosome
Accession NZ_CP007803
Organism Mycobacterium tuberculosis K

Toxin (Protein)


Gene name mazF Uniprot ID G0TJ74
Locus tag MTBK_RS07860 Protein ID WP_003407593.1
Coordinates 1677002..1677319 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TJ73
Locus tag MTBK_RS07855 Protein ID WP_003900349.1
Coordinates 1676703..1677005 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTBK_RS07845 1672589..1674436 + 1848 WP_003407585.1 methylmalonyl-CoA mutase small subunit -
MTBK_RS07850 1674437..1676689 + 2253 WP_003407587.1 methylmalonyl-CoA mutase -
MTBK_RS07855 1676703..1677005 + 303 WP_003900349.1 type II toxin-antitoxin system antitoxin MazE4 Antitoxin
MTBK_RS07860 1677002..1677319 + 318 WP_003407593.1 type II toxin-antitoxin system toxin endoribonuclease MazF4 Toxin
MTBK_RS07865 1677316..1678320 + 1005 WP_003407596.1 methylmalonyl Co-A mutase-associated GTPase MeaB -
MTBK_RS07870 1678373..1679662 + 1290 WP_038437345.1 serine hydrolase -
MTBK_RS07875 1679735..1680370 - 636 WP_071854212.1 class I SAM-dependent methyltransferase -
MTBK_RS07880 1680566..1680778 - 213 WP_003898900.1 dodecin family protein -
MTBK_RS22410 1680788..1681012 - 225 WP_160522526.1 NUDIX domain-containing protein -
MTBK_RS07890 1681282..1682310 + 1029 WP_003407612.1 glycosyltransferase family 2 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-99)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11377.97 Da        Isoelectric Point: 7.9950

>T47111 WP_003407593.1 NZ_CP007803:1677002-1677319 [Mycobacterium tuberculosis K]
VNAPLRGQVYRCDLGYGAKPWLIVSNNARNRHTADVVAVRLTTTRRTIPTWVAMGPSDPLTGYVNADNIETLGKDELGDY
LGEVTPATMNKINTALATALGLPWP

Download         Length: 318 bp

>T47111 NZ_CP007803:1677002-1677319 [Mycobacterium tuberculosis K]
GTGAACGCGCCGTTGCGTGGTCAGGTCTATCGATGCGACCTCGGATACGGGGCCAAACCGTGGCTCATCGTCTCCAACAA
CGCCCGCAACCGTCACACCGCCGACGTGGTGGCTGTGCGCCTGACAACAACGCGGAGAACCATACCGACCTGGGTCGCCA
TGGGCCCCAGCGATCCATTGACCGGATACGTCAACGCGGACAACATCGAGACCCTCGGCAAAGACGAGCTCGGTGACTAC
CTCGGTGAGGTCACGCCGGCGACGATGAACAAAATCAACACGGCGCTCGCGACCGCGCTGGGGCTACCGTGGCCATGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11173.42 Da        Isoelectric Point: 9.5564

>AT47111 WP_003900349.1 NZ_CP007803:1676703-1677005 [Mycobacterium tuberculosis K]
VPFLVALSGIISGVRDHSMTVRLDQQTRQRLQDIVKGGYRSANAAIVDAINKRWEALHDEQLDAAYAAAIHDNPAYPYES
EAERSAARARRNARQQRSAQ

Download         Length: 303 bp

>AT47111 NZ_CP007803:1676703-1677005 [Mycobacterium tuberculosis K]
GTGCCGTTTCTGGTTGCATTATCCGGTATCATCTCGGGCGTGCGTGATCATTCGATGACCGTGCGGCTCGACCAGCAAAC
TCGCCAGCGCCTGCAAGACATTGTGAAAGGCGGATACCGGAGCGCTAATGCGGCGATCGTCGACGCCATCAACAAGCGCT
GGGAGGCGCTACACGATGAGCAACTCGACGCCGCCTACGCGGCCGCGATCCATGACAATCCGGCGTACCCGTACGAGTCT
GAGGCCGAACGGAGCGCCGCGCGGGCCCGGCGCAACGCCAGGCAGCAGCGCTCGGCACAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5XE3
PDB 5XE2

Antitoxin

Source ID Structure
PDB 5XE3
AlphaFold DB G0TJ73

References