Detailed information of TA system TA047094

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 697144..697787
• Replicon: chromosome
• Accession: NZ_CP007803
• Organism: Mycobacterium tuberculosis K

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: P67239
• Locus tag: MTBK_RS03155
• Protein ID: WP_003403187.1
• Coordinates: 697386..697787 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TQ91
• Locus tag: MTBK_RS03150
• Protein ID: WP_003403184.1
• Coordinates: 697144..697389 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MTBK_RS03115	692424..692894	-	471	WP_003403144.1	HAMP domain-containing protein	-
MTBK_RS03120	692938..693699	-	762	WP_003403148.1	two-component system response regulator TcrA	-
MTBK_RS03125	693756..694067	+	312	WP_003403164.1	hypothetical protein	-
MTBK_RS03130	694139..695089	+	951	WP_003900184.1	DUF1259 domain-containing protein	-
MTBK_RS03135	695330..695914	+	585	WP_003403171.1	IS607-like element IS1536 family transposase	-
MTBK_RS03140	695916..696659	+	744	WP_003403177.1	IS607 family element transposase accessory protein TnpB	-
MTBK_RS03145	696713..697099	+	387	WP_003403180.1	hypothetical protein	-
MTBK_RS03150	697144..697389	+	246	WP_003403184.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
MTBK_RS03155	697386..697787	+	402	WP_003403187.1	type II toxin-antitoxin system VapC family toxin	Toxin
MTBK_RS03160	697730..697957	+	228	WP_003900974.1	hypothetical protein	-
MTBK_RS21965	698175..698342	-	168	WP_077385191.1	DUF3800 domain-containing protein	-
MTBK_RS21970	698375..698572	-	198	WP_003403191.1	hypothetical protein	-
MTBK_RS03170	698652..699809	-	1158	WP_003898524.1	hypothetical protein	-
MTBK_RS03175	699861..700082	-	222	WP_003898525.1	DUF4926 domain-containing protein	-
MTBK_RS03180	700224..700829	+	606	WP_038437323.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-124)

Antitoxin

• Antitoxin VapB-like (1-80)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14501.21 Da
• Isoelectric Point: 4.4463

>T47094 WP_003403187.1 NZ_CP007803:697386-697787 [Mycobacterium tuberculosis K]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Nucleotide

• Length: 402 bp

>T47094 NZ_CP007803:697386-697787 [Mycobacterium tuberculosis K]
GTGATCGTCGACACGTCGGCGATCATCGCGATTCTGCGCGACGAGGACGACGCCGCGGCCTACGCCGACGCGCTCGCCAA
CGCCGATGTCCGCAGACTGTCTGCGGCCAGCTACCTGGAATGCGGGATAGTCCTTGACTCCCAGCGTGATCCGGTCATCA
GCAGAGCACTGGATGAACTTATCGAAGAAGCCGAGTTCGTCGTCGAGCCGGTAACCGAGCGCCAGGCCCGCCTGGCCCGA
GCGGCCTACGCGGATTTCGGCAGAGGCAGCGGCCACCCCGCGGGCTTGAATTTCGGCGACTGCCTGTCCTATGCACTGGC
GATCGATCGACGTGAGCCGCTGCTGTGGAAGGGCAACGACTTTGGGCACACCGGCGTCCAAAGGGCACTGGATCGGCGGT
GA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8813.12 Da
• Isoelectric Point: 10.3486

>AT47094 WP_003403184.1 NZ_CP007803:697144-697389 [Mycobacterium tuberculosis K]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Nucleotide

• Length: 246 bp

>AT47094 NZ_CP007803:697144-697389 [Mycobacterium tuberculosis K]
ATGGCGTTGAACATCAAAGATCCGTCGGTTCACCAGGCGGTCAAGCAGATCGCGAAAATCACCGGCGAATCTCAGGCTCG
GGCGGTGGCGACCGCGGTGAACGAGCGTCTGGCCAGACTGCGCAGCGACGATCTCGCCGCCCGGCTCTTGGCTATCGGCC
ACAAGACCGCGAGCAGGATGAGCCCGGAAGCAAAGCGCCTCGACCACGATGCTCTGCTGTATGACGAGCGAGGGCTGCCG
GCGTGA

Structures

Toxin

• AlphaFold DB: A0A7U4BSD6

Antitoxin

• AlphaFold DB: G0TQ91