Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/AbrB(antitoxin)
Location 691054..691700 Replicon chromosome
Accession NZ_CP007803
Organism Mycobacterium tuberculosis K

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ88
Locus tag MTBK_RS03100 Protein ID WP_003403137.1
Coordinates 691054..691467 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ89
Locus tag MTBK_RS03105 Protein ID WP_003403139.1
Coordinates 691464..691700 (-) Length 79 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTBK_RS03080 687137..688687 + 1551 WP_003403119.1 MCE family protein -
MTBK_RS03085 688739..689131 - 393 WP_003403122.1 type II toxin-antitoxin system toxin ribonuclease C4 -
MTBK_RS03090 689128..689385 - 258 WP_003403125.1 type II toxin-antitoxin system antitoxin VapB4 -
MTBK_RS03095 689568..690803 - 1236 WP_003403128.1 ATP-binding protein -
MTBK_RS03100 691054..691467 - 414 WP_003403137.1 type II toxin-antitoxin system VapC family toxin Toxin
MTBK_RS03105 691464..691700 - 237 WP_003403139.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
MTBK_RS03110 691804..692310 - 507 WP_003900973.1 two component system sensor kinase HK1 -
MTBK_RS03115 692424..692894 - 471 WP_003403144.1 HAMP domain-containing protein -
MTBK_RS03120 692938..693699 - 762 WP_003403148.1 two-component system response regulator TcrA -
MTBK_RS03125 693756..694067 + 312 WP_003403164.1 hypothetical protein -
MTBK_RS03130 694139..695089 + 951 WP_003900184.1 DUF1259 domain-containing protein -
MTBK_RS03135 695330..695914 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
MTBK_RS03140 695916..696659 + 744 WP_003403177.1 IS607 family element transposase accessory protein TnpB -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(7-126)

Antitoxin

(3-43)


Sequences


Toxin        


Download         Length: 138 a.a.        Molecular weight: 14786.14 Da        Isoelectric Point: 8.1405

>T47093 WP_003403137.1 NZ_CP007803:c691467-691054 [Mycobacterium tuberculosis K]
VKPPLAVDTSVAIPLLVRTHTAHAAVVAWWAHREAALCGHALAETYSVLTRLPRDLRLAPMDAARLLTERFAAPLLLSSR
TTEHLPRVLAQFEITGGAVYDALVALAAAEHRAELATRDARAKDTYEKIGVHVVVAA

Download         Length: 414 bp

>T47093 NZ_CP007803:c691467-691054 [Mycobacterium tuberculosis K]
GTGAAACCGCCGCTGGCAGTGGACACCAGCGTCGCGATTCCGTTGCTGGTACGGACCCATACCGCGCATGCGGCGGTTGT
CGCCTGGTGGGCACATCGGGAGGCCGCGCTGTGCGGGCACGCCCTGGCCGAAACCTACTCCGTGCTGACCCGCCTGCCGC
GTGACCTACGACTGGCACCGATGGACGCCGCGCGGCTTCTTACCGAACGCTTTGCGGCACCGCTGTTGTTGAGTTCCCGC
ACCACTGAACATCTCCCACGCGTGCTGGCCCAATTCGAGATCACTGGTGGCGCGGTCTATGACGCTCTCGTGGCCCTTGC
CGCCGCCGAGCACCGGGCTGAACTCGCCACACGCGATGCTCGAGCCAAGGACACTTACGAAAAGATCGGCGTCCACGTCG
TTGTCGCCGCGTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8212.41 Da        Isoelectric Point: 5.0351

>AT47093 WP_003403139.1 NZ_CP007803:c691700-691464 [Mycobacterium tuberculosis K]
MKAVVDAAGRIVVPKPLREALGLQPGSTVEISRYGAGLHLIPTGRTARLEEENGVLVATGETTIDDEVVFGLIDSGRK

Download         Length: 237 bp

>AT47093 NZ_CP007803:c691700-691464 [Mycobacterium tuberculosis K]
ATGAAGGCTGTTGTGGATGCGGCTGGCCGCATCGTCGTACCCAAACCGCTGCGCGAAGCCTTGGGGCTGCAACCGGGGTC
CACCGTGGAAATATCCCGCTATGGCGCTGGTCTCCACCTGATTCCCACCGGACGAACAGCGCGTCTCGAAGAGGAGAATG
GCGTACTGGTGGCCACCGGTGAGACCACGATCGACGATGAGGTCGTGTTCGGCCTTATCGATAGCGGCCGGAAGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G0TQ88


Antitoxin

Source ID Structure
AlphaFold DB G0TQ89

References