Detailed information of TA system TA047085

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 329684..330318
• Replicon: chromosome
• Accession: NZ_CP007803
• Organism: Mycobacterium tuberculosis K

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: P9WF84
• Locus tag: MTBK_RS01460
• Protein ID: WP_003401406.1
• Coordinates: 329684..330112 (-)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: MTBK_RS01465
• Protein ID: WP_011961607.1
• Coordinates: 330136..330318 (-)
• Length: 61 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MTBK_RS01435	325551..326684	-	1134	WP_003401394.1	hypothetical protein	-
MTBK_RS01440	326681..327301	-	621	WP_003401397.1	TetR/AcrR family transcriptional regulator	-
MTBK_RS01445	327398..327979	+	582	WP_003401399.1	VOC family protein	-
MTBK_RS01450	327909..328634	-	726	WP_020699769.1	TetR/AcrR family transcriptional regulator	-
MTBK_RS01455	328724..329644	+	921	WP_003401404.1	DUF2236 domain-containing protein	-
MTBK_RS01460	329684..330112	-	429	WP_003401406.1	type II toxin-antitoxin system VapC family toxin	Toxin
MTBK_RS01465	330136..330318	-	183	WP_011961607.1	hypothetical protein	Antitoxin
MTBK_RS01470	330413..333202	-	2790	WP_038437318.1	PE family protein	-
MTBK_RS01475	333493..335103	+	1611	WP_003902643.1	PPE family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-133)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 15887.27 Da
• Isoelectric Point: 7.2214

>T47085 WP_003401406.1 NZ_CP007803:c330112-329684 [Mycobacterium tuberculosis K]
MFLIDVNVLLAAHRGDHPNHRTVRPWFDRLLAADDPFTVPNLVWASFLRLTTNRRIFEIPSPRADAFAFVEAVNAQPHHL
PTSPGPRHLVLLRKLCDEADASGDLIPDAVLGAIAVEHHCAVVSLDRDFARFASVRHIRPPI

Nucleotide

• Length: 429 bp

>T47085 NZ_CP007803:c330112-329684 [Mycobacterium tuberculosis K]
ATGTTCCTCATCGACGTCAACGTGCTGCTGGCTGCACACCGCGGTGACCATCCGAATCACCGAACCGTCCGCCCCTGGTT
CGATCGACTGCTTGCGGCCGACGACCCCTTCACAGTGCCGAACCTAGTGTGGGCGTCGTTCCTCCGGCTAACAACGAATC
GACGCATCTTCGAGATTCCGTCACCACGAGCGGATGCATTCGCATTCGTCGAAGCCGTCAACGCCCAGCCCCATCACCTT
CCGACAAGCCCCGGCCCCAGACACCTGGTGCTGCTGCGAAAACTCTGCGACGAGGCCGACGCATCGGGCGACTTGATACC
TGACGCGGTACTCGGGGCCATCGCCGTGGAGCATCACTGCGCCGTGGTGAGCCTGGATAGGGATTTCGCCCGGTTTGCCT
CTGTGCGCCATATTCGCCCGCCAATCTAG

Antitoxin

Protein

• Length: 61 a.a.
• Molecular weight: 6262.06 Da
• Isoelectric Point: 4.5878

>AT47085 WP_011961607.1 NZ_CP007803:c330318-330136 [Mycobacterium tuberculosis K]
MGAVIEDALRRELAAARTGGARPTVPVFDAGTGPRPGIDLTSNTVLSEVLDEGLELNSRK

Nucleotide

• Length: 183 bp

>AT47085 NZ_CP007803:c330318-330136 [Mycobacterium tuberculosis K]
CTGGGCGCTGTGATCGAAGACGCCCTTCGGCGGGAGCTCGCCGCCGCCCGTACCGGCGGCGCCCGGCCAACCGTCCCCGT
TTTTGACGCCGGCACCGGTCCGCGGCCAGGTATCGACCTAACCTCGAATACGGTGTTGTCCGAAGTGCTCGACGAGGGTC
TGGAACTGAACTCGCGGAAGTGA

Structures

Toxin

• AlphaFold DB: A0A7U4BRM6