Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 637690..638345 Replicon chromosome
Accession NZ_CP007802
Organism Burkholderia mallei NCTC 10247

Toxin (Protein)


Gene name relE Uniprot ID A0A0H2WL39
Locus tag BM44_RS12850 Protein ID WP_004199884.1
Coordinates 638049..638345 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q63YL3
Locus tag BM44_RS12845 Protein ID WP_004202809.1
Coordinates 637690..638046 (-) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BM44_RS12815 633822..634580 + 759 WP_004199892.1 cytochrome c1 -
BM44_RS12820 634673..635284 + 612 WP_004185176.1 glutathione S-transferase N-terminal domain-containing protein -
BM44_RS12825 635354..635875 + 522 WP_004199890.1 ClpXP protease specificity-enhancing factor -
BM44_RS12835 636097..636594 + 498 WP_004199888.1 terminase -
BM44_RS12840 636591..637646 + 1056 WP_004199886.1 phage portal protein -
BM44_RS12845 637690..638046 - 357 WP_004202809.1 putative addiction module antidote protein Antitoxin
BM44_RS12850 638049..638345 - 297 WP_004199884.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BM44_RS29450 639153..640272 + 1120 Protein_589 IS3 family transposase -
BM44_RS33155 640300..640437 - 138 WP_004202832.1 hypothetical protein -
BM44_RS12865 640424..640864 - 441 WP_009935860.1 BPSL0067 family protein -
BM44_RS12870 641420..641884 + 465 WP_073699083.1 hypothetical protein -
BM44_RS12875 642220..642786 + 567 WP_004525805.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 636280..640272 3992


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(8-97)

Antitoxin

Uncharacterized protein HI1420

(16-94)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10840.66 Da        Isoelectric Point: 10.1723

>T47083 WP_004199884.1 NZ_CP007802:c638345-638049 [Burkholderia mallei NCTC 10247]
MFKVLTPPQFDKWLDGLRDPVGSAAINLRIERAKLGNLGQWRAVGDGVNEMKIDVGPGYRAYFVRRGKIIVVVLCGGDKS
TQKKDIKLAKQIAGELED

Download         Length: 297 bp

>T47083 NZ_CP007802:c638345-638049 [Burkholderia mallei NCTC 10247]
ATGTTCAAAGTTCTGACGCCCCCCCAGTTTGACAAATGGCTTGACGGGCTTCGCGATCCGGTCGGTAGCGCGGCAATCAA
CCTGCGCATCGAGCGGGCGAAGCTTGGCAATCTCGGCCAGTGGCGCGCAGTCGGCGACGGCGTCAACGAAATGAAGATTG
ATGTGGGGCCGGGATATCGGGCCTATTTCGTGCGGCGCGGAAAAATTATCGTCGTGGTGTTGTGCGGCGGGGACAAGTCG
ACGCAGAAGAAGGACATCAAGCTAGCGAAGCAAATCGCTGGCGAACTGGAGGATTGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 12585.41 Da        Isoelectric Point: 9.9470

>AT47083 WP_004202809.1 NZ_CP007802:c638046-637690 [Burkholderia mallei NCTC 10247]
MKISELAEFDGSKYLKDEETIRHYLAQAFEDGNPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIM
KVVGALGLHLTVAPAEPAPVPAPATTRARSRVRTAAHA

Download         Length: 357 bp

>AT47083 NZ_CP007802:c638046-637690 [Burkholderia mallei NCTC 10247]
ATGAAAATCAGCGAACTGGCCGAGTTCGACGGCTCGAAGTACCTGAAGGACGAGGAAACGATTCGTCACTACCTGGCGCA
AGCGTTCGAGGATGGAAACCCGCGGCTGATTCAAGCCGCGCTCGGAAACGTCGCGAAAGCGCGCGGCATGACAGCGCTCG
CGCGCGAGTCCGGCGTGAAGCGTGAAGCGCTCTATCGCGCGCTGTCGGAAGGTGGGAACGCGGAATTCGCAACGATCATG
AAAGTTGTGGGCGCGTTGGGGCTGCACCTGACCGTTGCGCCGGCCGAACCTGCGCCGGTGCCCGCGCCGGCAACAACGCG
TGCACGCTCGCGCGTTCGCACGGCTGCGCACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2WL39

Antitoxin

Source ID Structure
AlphaFold DB A0A3N4G1D3

References