Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yjhX-yjhQ/YjhX-GNAT |
| Location | 5386650..5387470 | Replicon | chromosome |
| Accession | NZ_CP007799 | ||
| Organism | Escherichia coli Nissle 1917 | ||
Toxin (Protein)
| Gene name | yjhX | Uniprot ID | B6I030 |
| Locus tag | ECOLIN_RS26905 | Protein ID | WP_001054379.1 |
| Coordinates | 5386650..5386907 (+) | Length | 86 a.a. |
Antitoxin (Protein)
| Gene name | yjhQ | Uniprot ID | - |
| Locus tag | ECOLIN_RS26910 | Protein ID | WP_000123957.1 |
| Coordinates | 5386919..5387470 (+) | Length | 184 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ECOLIN_RS30210 | 5381796..5381945 | + | 150 | Protein_5092 | ClbS/DfsB family four-helix bundle protein | - |
| ECOLIN_RS26885 (ECOLIN_26110) | 5381964..5383184 | + | 1221 | WP_000343765.1 | ISL3-like element ISEc53 family transposase | - |
| ECOLIN_RS26890 (ECOLIN_26115) | 5383760..5384866 | - | 1107 | Protein_5094 | helicase YjhR | - |
| ECOLIN_RS31155 | 5384929..5386076 | + | 1148 | WP_085949154.1 | IS3-like element ISEc52 family transposase | - |
| ECOLIN_RS30225 | 5386109..5386273 | + | 165 | Protein_5096 | GNAT family N-acetyltransferase | - |
| ECOLIN_RS26905 (ECOLIN_26135) | 5386650..5386907 | + | 258 | WP_001054379.1 | YjhX family toxin | Toxin |
| ECOLIN_RS26910 (ECOLIN_26140) | 5386919..5387470 | + | 552 | WP_000123957.1 | N-acetyltransferase | Antitoxin |
| ECOLIN_RS26915 (ECOLIN_26145) | 5387522..5388268 | + | 747 | WP_000354249.1 | class I SAM-dependent methyltransferase | - |
| ECOLIN_RS26920 (ECOLIN_26150) | 5388396..5388656 | + | 261 | WP_000077645.1 | hypothetical protein | - |
| ECOLIN_RS32575 | 5388694..5388810 | + | 117 | Protein_5101 | VOC family protein | - |
| ECOLIN_RS26925 (ECOLIN_26155) | 5389055..5390176 | + | 1122 | WP_000010833.1 | M42 family metallopeptidase | - |
| ECOLIN_RS26930 (ECOLIN_26160) | 5390173..5390451 | + | 279 | WP_000722973.1 | PTS sugar transporter subunit IIB | - |
| ECOLIN_RS26935 (ECOLIN_26165) | 5390463..5391776 | + | 1314 | WP_000460845.1 | galactitol-specific PTS transporter subunit IIC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 5384929..5395691 | 10762 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 9568.07 Da Isoelectric Point: 11.1381
>T47056 WP_001054379.1 NZ_CP007799:5386650-5386907 [Escherichia coli Nissle 1917]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR
Download Length: 258 bp
>T47056 NZ_CP007799:5386650-5386907 [Escherichia coli Nissle 1917]
ATGAATTTATCCCGTCAGGAACAACGTACGTTACACGTTCTCGCTAAAGGTGGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGTCAGCCCTATCGAATCAACACTACCGGGCTGAATAACGTTCGCGCT
CAGCTCGATAATCGCTAA
ATGAATTTATCCCGTCAGGAACAACGTACGTTACACGTTCTCGCTAAAGGTGGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGTCAGCCCTATCGAATCAACACTACCGGGCTGAATAACGTTCGCGCT
CAGCTCGATAATCGCTAA
Antitoxin
Download Length: 184 a.a. Molecular weight: 20358.34 Da Isoelectric Point: 6.4182
>AT47056 WP_000123957.1 NZ_CP007799:5386919-5387470 [Escherichia coli Nissle 1917]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE
Download Length: 552 bp
>AT47056 NZ_CP007799:5386919-5387470 [Escherichia coli Nissle 1917]
ATGACAGCACACCACTTCACTTTTCAAATCACAGATGAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAACGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCTGCGTTATCGCTGCTGGCCC
GACATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGGGAAATGGATTCACCGCTGATGCAT
ATCCTCGCTCCCCTGGCAGTCATACCGGAATACCAGGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAAGCACTCACCGCT
CAGCCCATGAACGTGACCGGCCACATCCAGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA
ATGACAGCACACCACTTCACTTTTCAAATCACAGATGAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAACGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCTGCGTTATCGCTGCTGGCCC
GACATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGGGAAATGGATTCACCGCTGATGCAT
ATCCTCGCTCCCCTGGCAGTCATACCGGAATACCAGGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAAGCACTCACCGCT
CAGCCCATGAACGTGACCGGCCACATCCAGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|