Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 5238905..5239736 Replicon chromosome
Accession NZ_CP007799
Organism Escherichia coli Nissle 1917

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag ECOLIN_RS26115 Protein ID WP_000854814.1
Coordinates 5238905..5239279 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag ECOLIN_RS26120 Protein ID WP_038427208.1
Coordinates 5239368..5239736 (-) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECOLIN_RS26080 (ECOLIN_25295) 5233970..5234434 - 465 WP_000347252.1 type II toxin-antitoxin system ribonuclease toxin YhaV -
ECOLIN_RS26085 (ECOLIN_25300) 5234434..5234769 - 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF -
ECOLIN_RS26090 (ECOLIN_25305) 5234918..5235769 - 852 Protein_4938 UxaA family hydrolase -
ECOLIN_RS26095 (ECOLIN_25310) 5235746..5236864 + 1119 WP_128971752.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
ECOLIN_RS31880 5237055..5237138 + 84 Protein_4940 type II toxin-antitoxin system HigB family toxin -
ECOLIN_RS26100 (ECOLIN_25315) 5237135..5237551 + 417 WP_000560266.1 type II toxin-antitoxin system antitoxin HigA -
ECOLIN_RS26105 (ECOLIN_25320) 5237596..5238330 - 735 Protein_4942 NADPH-dependent 2,4-dienoyl-CoA reductase -
ECOLIN_RS32225 5238576..5238689 - 114 WP_001161660.1 DUF957 domain-containing protein -
ECOLIN_RS26110 (ECOLIN_25325) 5238702..5238908 - 207 WP_128971753.1 hypothetical protein -
ECOLIN_RS26115 (ECOLIN_25330) 5238905..5239279 - 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
ECOLIN_RS26120 (ECOLIN_25335) 5239368..5239736 - 369 WP_038427208.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
ECOLIN_RS26125 (ECOLIN_25340) 5239810..5240031 - 222 WP_000692323.1 DUF987 domain-containing protein -
ECOLIN_RS26130 (ECOLIN_25345) 5240100..5240576 - 477 WP_001186170.1 RadC family protein -
ECOLIN_RS26135 (ECOLIN_25350) 5240592..5241077 - 486 WP_000213703.1 antirestriction protein -
ECOLIN_RS32440 5241168..5241320 - 153 Protein_4950 DUF945 domain-containing protein -
ECOLIN_RS26140 (ECOLIN_25355) 5241318..5242106 + 789 Protein_4951 galactose/glucose ABC transporter substrate-binding protein MglB -
ECOLIN_RS26145 (ECOLIN_25360) 5242167..5243687 + 1521 WP_000255034.1 galactose/methyl galactoside ABC transporter ATP-binding protein MglA -
ECOLIN_RS26150 (ECOLIN_25365) 5243703..5244713 + 1011 WP_001275112.1 galactose/methyl galactoside ABC transporter permease MglC -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T47055 WP_000854814.1 NZ_CP007799:c5239279-5238905 [Escherichia coli Nissle 1917]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T47055 NZ_CP007799:c5239279-5238905 [Escherichia coli Nissle 1917]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13507.41 Da        Isoelectric Point: 6.4652

>AT47055 WP_038427208.1 NZ_CP007799:c5239736-5239368 [Escherichia coli Nissle 1917]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT47055 NZ_CP007799:c5239736-5239368 [Escherichia coli Nissle 1917]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCCCCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A829FY50


Antitoxin

Source ID Structure

References