Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4828330..4829165 Replicon chromosome
Accession NZ_CP007799
Organism Escherichia coli Nissle 1917

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag ECOLIN_RS23950 Protein ID WP_038427178.1
Coordinates 4828330..4828707 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag ECOLIN_RS23955 Protein ID WP_038427179.1
Coordinates 4828797..4829165 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECOLIN_RS23915 (ECOLIN_23170) 4824473..4826011 - 1539 WP_001187191.1 lysine decarboxylation/transport transcriptional activator CadC -
ECOLIN_RS29615 (ECOLIN_23180) 4826653..4827168 - 516 Protein_4536 DUF4942 domain-containing protein -
ECOLIN_RS23935 (ECOLIN_23185) 4827149..4827664 - 516 Protein_4537 DUF4942 domain-containing protein -
ECOLIN_RS31760 (ECOLIN_23190) 4827749..4827942 - 194 Protein_4538 hypothetical protein -
ECOLIN_RS31765 4827949..4828333 - 385 Protein_4539 hypothetical protein -
ECOLIN_RS23950 (ECOLIN_23200) 4828330..4828707 - 378 WP_038427178.1 TA system toxin CbtA family protein Toxin
ECOLIN_RS23955 (ECOLIN_23205) 4828797..4829165 - 369 WP_038427179.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
ECOLIN_RS23960 (ECOLIN_23210) 4829184..4829405 - 222 WP_000692345.1 DUF987 domain-containing protein -
ECOLIN_RS23965 (ECOLIN_23215) 4829464..4829940 - 477 WP_001186775.1 RadC family protein -
ECOLIN_RS31770 4829955..4830332 - 378 Protein_4544 antirestriction protein -
ECOLIN_RS29620 4830333..4830864 - 532 Protein_4545 DUF945 domain-containing protein -
ECOLIN_RS30990 4831081..4831979 + 899 Protein_4546 transposase -
ECOLIN_RS32400 4832189..4832254 - 66 Protein_4547 F7-2 fimbrial protein -
ECOLIN_RS23995 (ECOLIN_23250) 4832462..4832776 - 315 WP_021528731.1 adhesin biosynthesis transcription regulatory family protein -
ECOLIN_RS24000 (ECOLIN_23255) 4833199..4833432 + 234 WP_000006213.1 major pilus subunit operon transcriptional regulator PapI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14163.30 Da        Isoelectric Point: 7.7294

>T47051 WP_038427178.1 NZ_CP007799:c4828707-4828330 [Escherichia coli Nissle 1917]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDLPGF
SACTRSQLINSIDILRARRATGLMIRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T47051 NZ_CP007799:c4828707-4828330 [Escherichia coli Nissle 1917]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCAGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGTACCGACCTGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGATCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13602.43 Da        Isoelectric Point: 6.6255

>AT47051 WP_038427179.1 NZ_CP007799:c4829165-4828797 [Escherichia coli Nissle 1917]
VSDTLPGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT47051 NZ_CP007799:c4829165-4828797 [Escherichia coli Nissle 1917]
GTGTCAGACACACTGCCCGGGACAACGCATCCCGATGACAATGACGACCACCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References