Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | ykfI-yeeU/CbtA-CbeA |
| Location | 4230633..4231424 | Replicon | chromosome |
| Accession | NZ_CP007799 | ||
| Organism | Escherichia coli Nissle 1917 | ||
Toxin (Protein)
| Gene name | ykfI | Uniprot ID | - |
| Locus tag | ECOLIN_RS21040 | Protein ID | WP_000691791.1 |
| Coordinates | 4230999..4231424 (+) | Length | 142 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A3L1KVZ6 |
| Locus tag | ECOLIN_RS21035 | Protein ID | WP_000939437.1 |
| Coordinates | 4230633..4230968 (+) | Length | 112 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ECOLIN_RS21010 (ECOLIN_20305) | 4226584..4226802 | - | 219 | WP_000070772.1 | AlpA family phage regulatory protein | - |
| ECOLIN_RS21015 (ECOLIN_20310) | 4226920..4227534 | - | 615 | WP_000772910.1 | inovirus Gp2 family protein | - |
| ECOLIN_RS21020 (ECOLIN_20315) | 4228127..4229080 | + | 954 | WP_000290406.1 | hypothetical protein | - |
| ECOLIN_RS21025 (ECOLIN_20320) | 4229316..4230130 | + | 815 | Protein_4004 | DUF945 domain-containing protein | - |
| ECOLIN_RS21030 (ECOLIN_20325) | 4230160..4230633 | + | 474 | WP_001292742.1 | DNA repair protein RadC | - |
| ECOLIN_RS21035 (ECOLIN_20330) | 4230633..4230968 | + | 336 | WP_000939437.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| ECOLIN_RS21040 (ECOLIN_20335) | 4230999..4231424 | + | 426 | WP_000691791.1 | TA system toxin CbtA family protein | Toxin |
| ECOLIN_RS21045 (ECOLIN_20340) | 4231445..4232636 | + | 1192 | Protein_4008 | AAA family ATPase | - |
| ECOLIN_RS31705 | 4232621..4232842 | + | 222 | WP_125112077.1 | hypothetical protein | - |
| ECOLIN_RS21050 (ECOLIN_20345) | 4232839..4233570 | + | 732 | WP_001216639.1 | TIGR02646 family protein | - |
| ECOLIN_RS21060 (ECOLIN_20355) | 4234193..4234579 | + | 387 | WP_001270938.1 | DUF2441 domain-containing protein | - |
| ECOLIN_RS31710 (ECOLIN_20360) | 4234723..4235120 | + | 398 | Protein_4012 | antirestriction protein | - |
| ECOLIN_RS21070 | 4235135..4235590 | + | 456 | Protein_4013 | RadC family protein | - |
| ECOLIN_RS31715 | 4235618..4235764 | + | 147 | Protein_4014 | DUF987 family protein | - |
| ECOLIN_RS21075 (ECOLIN_20370) | 4235757..4236005 | + | 249 | Protein_4015 | type IV toxin-antitoxin system YeeU family antitoxin | - |
| ECOLIN_RS21080 (ECOLIN_20375) | 4236095..4236385 | + | 291 | WP_051763871.1 | TA system toxin CbtA family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 142 a.a. Molecular weight: 16490.11 Da Isoelectric Point: 10.2376
>T47048 WP_000691791.1 NZ_CP007799:4230999-4231424 [Escherichia coli Nissle 1917]
MKIIPATTLRATTSYLSPVVVWQTLLARLLEQHYGLNLNDTPFNNEKVIQEHIDAGITLVNAVNFLVEKYELVRIDRKGF
SWQEQTPYLRAVDILRARQATGLRIQCKNTNIISRMADSRHDKRLYQRTFKACKRCYYTKT
MKIIPATTLRATTSYLSPVVVWQTLLARLLEQHYGLNLNDTPFNNEKVIQEHIDAGITLVNAVNFLVEKYELVRIDRKGF
SWQEQTPYLRAVDILRARQATGLRIQCKNTNIISRMADSRHDKRLYQRTFKACKRCYYTKT
Download Length: 426 bp
>T47048 NZ_CP007799:4230999-4231424 [Escherichia coli Nissle 1917]
ATGAAAATTATTCCTGCAACGACGCTGCGGGCGACGACGTCATATCTGTCTCCTGTCGTGGTCTGGCAAACATTACTGGC
CCGCCTGCTGGAGCAGCACTACGGGCTGAATCTTAATGACACACCATTCAACAATGAAAAGGTGATTCAGGAACACATAG
ACGCCGGGATCACTCTGGTCAATGCCGTCAATTTTCTGGTGGAGAAGTACGAATTGGTCCGTATCGACAGGAAAGGATTT
AGCTGGCAGGAACAGACGCCTTATCTTCGTGCGGTCGATATTTTGCGGGCGCGGCAGGCGACCGGCCTGCGGATTCAGTG
CAAAAACACGAATATAATCAGCCGGATGGCTGATTCAAGACATGATAAAAGACTTTACCAGCGCACGTTTAAAGCGTGCA
AGAGATGTTATTATACTAAAACATAA
ATGAAAATTATTCCTGCAACGACGCTGCGGGCGACGACGTCATATCTGTCTCCTGTCGTGGTCTGGCAAACATTACTGGC
CCGCCTGCTGGAGCAGCACTACGGGCTGAATCTTAATGACACACCATTCAACAATGAAAAGGTGATTCAGGAACACATAG
ACGCCGGGATCACTCTGGTCAATGCCGTCAATTTTCTGGTGGAGAAGTACGAATTGGTCCGTATCGACAGGAAAGGATTT
AGCTGGCAGGAACAGACGCCTTATCTTCGTGCGGTCGATATTTTGCGGGCGCGGCAGGCGACCGGCCTGCGGATTCAGTG
CAAAAACACGAATATAATCAGCCGGATGGCTGATTCAAGACATGATAAAAGACTTTACCAGCGCACGTTTAAAGCGTGCA
AGAGATGTTATTATACTAAAACATAA
Antitoxin
Download Length: 112 a.a. Molecular weight: 12556.56 Da Isoelectric Point: 7.6977
>AT47048 WP_000939437.1 NZ_CP007799:4230633-4230968 [Escherichia coli Nissle 1917]
MLQKDKVMQQEWGLPCTVTPRFTARLVQERHNLHYLADRAAITGKFSSPDLLHIDQAFPVLMKQLELKLADGELSPCQQR
TVTLYAKGLTCEADTLGSCGYVYIAIYPTQR
MLQKDKVMQQEWGLPCTVTPRFTARLVQERHNLHYLADRAAITGKFSSPDLLHIDQAFPVLMKQLELKLADGELSPCQQR
TVTLYAKGLTCEADTLGSCGYVYIAIYPTQR
Download Length: 336 bp
>AT47048 NZ_CP007799:4230633-4230968 [Escherichia coli Nissle 1917]
ATGCTGCAAAAGGACAAGGTCATGCAACAAGAATGGGGGCTTCCCTGTACCGTAACACCACGCTTCACTGCTCGACTGGT
ACAGGAAAGACATAACCTGCATTACCTGGCTGATCGGGCCGCAATCACCGGGAAATTCAGCTCCCCGGATCTGCTGCATA
TCGACCAGGCTTTTCCGGTGTTGATGAAACAACTGGAGCTGAAACTGGCTGACGGTGAACTCTCCCCCTGCCAACAACGT
ACCGTCACGCTATACGCCAAAGGACTAACCTGCGAAGCCGATACGCTGGGTTCCTGTGGTTACGTCTATATCGCTATTTA
TCCCACTCAACGCTGA
ATGCTGCAAAAGGACAAGGTCATGCAACAAGAATGGGGGCTTCCCTGTACCGTAACACCACGCTTCACTGCTCGACTGGT
ACAGGAAAGACATAACCTGCATTACCTGGCTGATCGGGCCGCAATCACCGGGAAATTCAGCTCCCCGGATCTGCTGCATA
TCGACCAGGCTTTTCCGGTGTTGATGAAACAACTGGAGCTGAAACTGGCTGACGGTGAACTCTCCCCCTGCCAACAACGT
ACCGTCACGCTATACGCCAAAGGACTAACCTGCGAAGCCGATACGCTGGGTTCCTGTGGTTACGTCTATATCGCTATTTA
TCCCACTCAACGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|