Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 3415518..3416353 | Replicon | chromosome |
| Accession | NZ_CP007799 | ||
| Organism | Escherichia coli Nissle 1917 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | S1PLF5 |
| Locus tag | ECOLIN_RS16965 | Protein ID | WP_000854690.1 |
| Coordinates | 3415976..3416353 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | ECOLIN_RS16960 | Protein ID | WP_038427157.1 |
| Coordinates | 3415518..3415886 (+) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ECOLIN_RS16910 (ECOLIN_16320) | 3410685..3411170 | + | 486 | WP_000849565.1 | antirestriction protein | - |
| ECOLIN_RS16915 (ECOLIN_16325) | 3411186..3411662 | + | 477 | WP_001186726.1 | RadC family protein | - |
| ECOLIN_RS16920 (ECOLIN_16330) | 3411725..3411946 | + | 222 | WP_000692329.1 | DUF987 domain-containing protein | - |
| ECOLIN_RS16925 | 3411965..3412288 | + | 324 | Protein_3217 | antitoxin of toxin-antitoxin stability system | - |
| ECOLIN_RS16930 (ECOLIN_16340) | 3412379..3412612 | + | 234 | WP_000902034.1 | DUF905 family protein | - |
| ECOLIN_RS16935 (ECOLIN_16345) | 3412713..3413531 | + | 819 | WP_001234620.1 | DUF945 domain-containing protein | - |
| ECOLIN_RS16940 (ECOLIN_16350) | 3413586..3414071 | + | 486 | WP_000849565.1 | antirestriction protein | - |
| ECOLIN_RS16945 (ECOLIN_16355) | 3414087..3414563 | + | 477 | WP_001186726.1 | RadC family protein | - |
| ECOLIN_RS16950 (ECOLIN_16360) | 3414626..3414847 | + | 222 | WP_000692329.1 | DUF987 domain-containing protein | - |
| ECOLIN_RS16955 (ECOLIN_16365) | 3414866..3415468 | + | 603 | WP_038427156.1 | hypothetical protein | - |
| ECOLIN_RS16960 (ECOLIN_16370) | 3415518..3415886 | + | 369 | WP_038427157.1 | type IV toxin-antitoxin system toxin CbtA | Antitoxin |
| ECOLIN_RS16965 (ECOLIN_16375) | 3415976..3416353 | + | 378 | WP_000854690.1 | TA system toxin CbtA family protein | Toxin |
| ECOLIN_RS16970 (ECOLIN_16380) | 3416350..3416838 | + | 489 | WP_000761699.1 | hypothetical protein | - |
| ECOLIN_RS16975 (ECOLIN_16385) | 3416855..3417052 | + | 198 | WP_000839293.1 | DUF957 domain-containing protein | - |
| ECOLIN_RS16980 (ECOLIN_16390) | 3417137..3417982 | + | 846 | WP_038427158.1 | DUF4942 domain-containing protein | - |
| ECOLIN_RS16985 (ECOLIN_16395) | 3418051..3418446 | + | 396 | WP_000208382.1 | type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein | - |
| ECOLIN_RS16990 (ECOLIN_16400) | 3418439..3419373 | + | 935 | Protein_3230 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | - |
| ECOLIN_RS32100 (ECOLIN_16405) | 3419805..3419960 | + | 156 | WP_000729638.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | Genomic island | - | - | 3379217..3419975 | 40758 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14057.04 Da Isoelectric Point: 9.1510
>T47046 WP_000854690.1 NZ_CP007799:3415976-3416353 [Escherichia coli Nissle 1917]
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYAQVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYAQVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR
Download Length: 378 bp
>T47046 NZ_CP007799:3415976-3416353 [Escherichia coli Nissle 1917]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCAGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCAGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13561.53 Da Isoelectric Point: 5.0465
>AT47046 WP_038427157.1 NZ_CP007799:3415518-3415886 [Escherichia coli Nissle 1917]
MSDTLPGTTLPDDNKDLPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCDYVYLAVYPTPEMKN
MSDTLPGTTLPDDNKDLPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCDYVYLAVYPTPEMKN
Download Length: 369 bp
>AT47046 NZ_CP007799:3415518-3415886 [Escherichia coli Nissle 1917]
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCTCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCCTCTGGACCAGGCCTTTCCACTGCTGATGAAACAACTGAAACTCATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCTCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCCTCTGGACCAGGCCTTTCCACTGCTGATGAAACAACTGAAACTCATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|