Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3407949..3408750 Replicon chromosome
Accession NZ_CP007799
Organism Escherichia coli Nissle 1917

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0H2V687
Locus tag ECOLIN_RS16890 Protein ID WP_000854739.1
Coordinates 3408370..3408750 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0P0SQV8
Locus tag ECOLIN_RS16885 Protein ID WP_001285481.1
Coordinates 3407949..3408323 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECOLIN_RS16850 (ECOLIN_16260) 3404033..3404488 + 456 WP_000581502.1 hypothetical protein -
ECOLIN_RS16855 (ECOLIN_16265) 3404593..3404802 + 210 WP_032142237.1 DUF905 family protein -
ECOLIN_RS16860 (ECOLIN_16270) 3404903..3405724 + 822 WP_038427155.1 DUF945 domain-containing protein -
ECOLIN_RS16865 (ECOLIN_16275) 3405987..3406460 + 474 WP_001537423.1 antirestriction protein -
ECOLIN_RS16870 (ECOLIN_16280) 3406476..3406952 + 477 WP_001186170.1 RadC family protein -
ECOLIN_RS16875 (ECOLIN_16285) 3407015..3407236 + 222 WP_000692312.1 DUF987 domain-containing protein -
ECOLIN_RS16880 (ECOLIN_16290) 3407255..3407899 + 645 WP_000094915.1 hypothetical protein -
ECOLIN_RS16885 (ECOLIN_16295) 3407949..3408323 + 375 WP_001285481.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
ECOLIN_RS16890 (ECOLIN_16300) 3408370..3408750 + 381 WP_000854739.1 TA system toxin CbtA family protein Toxin
ECOLIN_RS16895 (ECOLIN_16305) 3408747..3409190 + 444 Protein_3210 hypothetical protein -
ECOLIN_RS29120 3409190..3409399 + 210 WP_001355625.1 hypothetical protein -
ECOLIN_RS32370 3409520..3409731 - 212 Protein_3212 hypothetical protein -
ECOLIN_RS16905 (ECOLIN_16315) 3409812..3410630 + 819 WP_001234620.1 DUF945 domain-containing protein -
ECOLIN_RS16910 (ECOLIN_16320) 3410685..3411170 + 486 WP_000849565.1 antirestriction protein -
ECOLIN_RS16915 (ECOLIN_16325) 3411186..3411662 + 477 WP_001186726.1 RadC family protein -
ECOLIN_RS16920 (ECOLIN_16330) 3411725..3411946 + 222 WP_000692329.1 DUF987 domain-containing protein -
ECOLIN_RS16925 3411965..3412288 + 324 Protein_3217 antitoxin of toxin-antitoxin stability system -
ECOLIN_RS16930 (ECOLIN_16340) 3412379..3412612 + 234 WP_000902034.1 DUF905 family protein -
ECOLIN_RS16935 (ECOLIN_16345) 3412713..3413531 + 819 WP_001234620.1 DUF945 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 3379217..3419975 40758


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14214.14 Da        Isoelectric Point: 6.4773

>T47045 WP_000854739.1 NZ_CP007799:3408370-3408750 [Escherichia coli Nissle 1917]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGVPSQLINSIDILRARRATGLMTRDNYRTVNDITLGRHPEEAKQ

Download         Length: 381 bp

>T47045 NZ_CP007799:3408370-3408750 [Escherichia coli Nissle 1917]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGTCCCGTCGCAGTTAATCAACAGCATCGATATTCTCCGGGCCCGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATGACATTACCCTGGGCAGGCATCCGGAGGAGGCGAAACAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13817.53 Da        Isoelectric Point: 4.7511

>AT47045 WP_001285481.1 NZ_CP007799:3407949-3408323 [Escherichia coli Nissle 1917]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTIG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT47045 NZ_CP007799:3407949-3408323 [Escherichia coli Nissle 1917]
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCAGT
TCAGCGACGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCATCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2V687

Antitoxin

Source ID Structure
AlphaFold DB A0A0P0SQV8

References