Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2339595..2340426 Replicon chromosome
Accession NZ_CP007799
Organism Escherichia coli Nissle 1917

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag ECOLIN_RS11870 Protein ID WP_000854814.1
Coordinates 2340052..2340426 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag ECOLIN_RS11865 Protein ID WP_071925532.1
Coordinates 2339595..2339963 (+) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECOLIN_RS11830 (ECOLIN_11415) 2334812..2335882 + 1071 WP_000102631.1 patatin-like phospholipase family protein -
ECOLIN_RS11835 (ECOLIN_11420) 2336018..2336695 + 678 WP_001362823.1 hypothetical protein -
ECOLIN_RS11840 (ECOLIN_11425) 2336711..2337121 + 411 WP_000846704.1 hypothetical protein -
ECOLIN_RS11845 (ECOLIN_11430) 2337342..2338163 + 822 WP_001234569.1 DUF945 domain-containing protein -
ECOLIN_RS11850 (ECOLIN_11435) 2338254..2338739 + 486 WP_000213703.1 antirestriction protein -
ECOLIN_RS11855 (ECOLIN_11440) 2338755..2339231 + 477 WP_001351157.1 RadC family protein -
ECOLIN_RS11860 (ECOLIN_11445) 2339300..2339521 + 222 WP_000692323.1 DUF987 domain-containing protein -
ECOLIN_RS11865 (ECOLIN_11450) 2339595..2339963 + 369 WP_071925532.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
ECOLIN_RS11870 (ECOLIN_11455) 2340052..2340426 + 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
ECOLIN_RS11875 (ECOLIN_11460) 2340423..2340617 + 195 WP_000988601.1 hypothetical protein -
ECOLIN_RS32180 2340630..2340743 + 114 WP_001161660.1 DUF957 domain-containing protein -
ECOLIN_RS28730 2341032..2341178 - 147 Protein_2259 transposase domain-containing protein -
ECOLIN_RS11885 (ECOLIN_11465) 2341232..2341414 + 183 WP_001016348.1 hypothetical protein -
ECOLIN_RS11890 (ECOLIN_11470) 2341515..2341844 - 330 WP_000450409.1 DUF496 family protein -
ECOLIN_RS11895 (ECOLIN_11475) 2342016..2343074 - 1059 WP_001200890.1 FUSC family protein -
ECOLIN_RS11900 (ECOLIN_11480) 2343272..2343745 - 474 WP_001105376.1 DNA gyrase inhibitor SbmC -
ECOLIN_RS11905 (ECOLIN_11485) 2343864..2345030 - 1167 WP_001297905.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T47041 WP_000854814.1 NZ_CP007799:2340052-2340426 [Escherichia coli Nissle 1917]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T47041 NZ_CP007799:2340052-2340426 [Escherichia coli Nissle 1917]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13621.44 Da        Isoelectric Point: 4.7830

>AT47041 WP_071925532.1 NZ_CP007799:2339595-2339963 [Escherichia coli Nissle 1917]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRYQHTVTLYAKGLTCEADTLGSCDYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT47041 NZ_CP007799:2339595-2339963 [Escherichia coli Nissle 1917]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGTTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTCAGCCCCCGCTATCAGCATACCGTCACGCTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A829FY50


Antitoxin

Source ID Structure

References