Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1212388..1213189 Replicon chromosome
Accession NZ_CP007799
Organism Escherichia coli Nissle 1917

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0H2V687
Locus tag ECOLIN_RS05955 Protein ID WP_000854739.1
Coordinates 1212809..1213189 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0P7R0L9
Locus tag ECOLIN_RS05950 Protein ID WP_001285482.1
Coordinates 1212388..1212762 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECOLIN_RS27400 1207762..1208316 + 555 Protein_1126 hypothetical protein -
ECOLIN_RS05910 (ECOLIN_05770) 1208392..1208847 + 456 WP_000581502.1 hypothetical protein -
ECOLIN_RS32495 (ECOLIN_05775) 1208966..1209177 - 212 Protein_1128 hypothetical protein -
ECOLIN_RS05920 (ECOLIN_05780) 1209258..1210079 + 822 WP_001234710.1 DUF945 domain-containing protein -
ECOLIN_RS05925 (ECOLIN_05785) 1210079..1210267 + 189 WP_193790565.1 hypothetical protein -
ECOLIN_RS05930 (ECOLIN_05790) 1210419..1210892 + 474 WP_000855076.1 antirestriction protein -
ECOLIN_RS05935 (ECOLIN_05795) 1210908..1211384 + 477 WP_001186170.1 RadC family protein -
ECOLIN_RS05940 (ECOLIN_05800) 1211454..1211675 + 222 WP_000692312.1 DUF987 domain-containing protein -
ECOLIN_RS05945 (ECOLIN_05805) 1211694..1212338 + 645 WP_000094915.1 hypothetical protein -
ECOLIN_RS05950 (ECOLIN_05810) 1212388..1212762 + 375 WP_001285482.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
ECOLIN_RS05955 (ECOLIN_05815) 1212809..1213189 + 381 WP_000854739.1 TA system toxin CbtA family protein Toxin
ECOLIN_RS05960 (ECOLIN_05820) 1213186..1213674 + 489 WP_001054232.1 hypothetical protein -
ECOLIN_RS05965 (ECOLIN_05825) 1213694..1213891 + 198 WP_000772027.1 DUF957 domain-containing protein -
ECOLIN_RS05970 (ECOLIN_05830) 1213982..1214809 + 828 WP_001304477.1 DUF4942 domain-containing protein -
ECOLIN_RS05980 (ECOLIN_05845) 1215296..1216234 + 939 WP_000351287.1 glyoxylate/hydroxypyruvate reductase GhrA -
ECOLIN_RS05985 (ECOLIN_05850) 1216289..1216585 + 297 Protein_1141 zinc-binding phosphatase -
ECOLIN_RS32295 1216586..1217098 + 513 Protein_1142 DUF4942 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - csgG / csgF / csgE / csgD / csgB / csgA / csgC 1212388..1225427 13039


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14214.14 Da        Isoelectric Point: 6.4773

>T47030 WP_000854739.1 NZ_CP007799:1212809-1213189 [Escherichia coli Nissle 1917]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGVPSQLINSIDILRARRATGLMTRDNYRTVNDITLGRHPEEAKQ

Download         Length: 381 bp

>T47030 NZ_CP007799:1212809-1213189 [Escherichia coli Nissle 1917]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGTCCCGTCGCAGTTAATCAACAGCATCGATATTCTCCGGGCCCGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATGACATTACCCTGGGCAGGCATCCGGAGGAGGCGAAACAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13791.44 Da        Isoelectric Point: 4.7511

>AT47030 WP_001285482.1 NZ_CP007799:1212388-1212762 [Escherichia coli Nissle 1917]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT47030 NZ_CP007799:1212388-1212762 [Escherichia coli Nissle 1917]
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCAGT
TCAGCGACGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2V687

Antitoxin

Source ID Structure
AlphaFold DB A0A0P7R0L9

References