Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-vagC/VapC-VagC
Location 1780171..1780808 Replicon chromosome
Accession NZ_CP007787
Organism Burkholderia cepacia strain DDS 7H-2

Toxin (Protein)


Gene name vapC Uniprot ID A0A364GQ02
Locus tag DM42_RS27465 Protein ID WP_034201143.1
Coordinates 1780171..1780572 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A364GPY9
Locus tag DM42_RS27470 Protein ID WP_034201144.1
Coordinates 1780572..1780808 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DM42_RS27455 1777542..1778684 + 1143 WP_006485680.1 alginate lyase family protein -
DM42_RS27460 1778715..1780103 + 1389 WP_034201142.1 L-serine ammonia-lyase -
DM42_RS27465 1780171..1780572 - 402 WP_034201143.1 type II toxin-antitoxin system VapC family toxin Toxin
DM42_RS27470 1780572..1780808 - 237 WP_034201144.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
DM42_RS27475 1780926..1781155 - 230 Protein_1608 type II toxin-antitoxin system RelE/ParE family toxin -
DM42_RS27480 1781524..1783227 + 1704 WP_034201145.1 thiamine pyrophosphate-binding protein -
DM42_RS27485 1783224..1784321 + 1098 WP_034201146.1 ADP-heptose--LPS heptosyltransferase -
DM42_RS27490 1784431..1785447 - 1017 WP_034201147.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15099.33 Da        Isoelectric Point: 6.2271

>T47023 WP_034201143.1 NZ_CP007787:c1780572-1780171 [Burkholderia cepacia]
MPRFMLDTNMCIYLMKNQPEQVARRFARCYTGDVVMSAITYAELEYGLTACVNPARERRHLAALIEDIPVAPFDAAAAQA
YGPVREATRERKKDHLDKLIAAHAVSLDVVLVTNNERDFVSYPGLRLENWLND

Download         Length: 402 bp

>T47023 NZ_CP007787:c1780572-1780171 [Burkholderia cepacia]
ATGCCGCGCTTCATGCTCGACACCAATATGTGTATCTATCTGATGAAAAATCAGCCTGAGCAGGTCGCGAGACGGTTTGC
GCGGTGCTACACGGGCGACGTCGTCATGTCGGCGATCACCTATGCGGAGCTCGAGTACGGCCTGACCGCTTGTGTGAATC
CCGCGCGGGAGCGCCGCCATCTCGCCGCATTGATCGAGGATATTCCCGTCGCGCCTTTCGACGCGGCTGCCGCGCAAGCG
TATGGCCCGGTTCGCGAGGCCACCCGCGAGCGGAAGAAGGATCACCTCGACAAACTGATTGCCGCGCATGCGGTGTCGCT
CGATGTCGTCCTTGTCACCAACAACGAGCGCGATTTCGTCAGCTATCCGGGATTGCGACTGGAGAACTGGCTGAACGATT
AG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8982.15 Da        Isoelectric Point: 6.4701

>AT47023 WP_034201144.1 NZ_CP007787:c1780808-1780572 [Burkholderia cepacia]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERVGDEIRIRPMRRPLTQVLAKFAKFGPDFMADGRGDHEQAEREGL

Download         Length: 237 bp

>AT47023 NZ_CP007787:c1780808-1780572 [Burkholderia cepacia]
ATGCATACCACGAGGGTATTCAGGAACGGCAACTCGCAGGCCGTGCGAATTCCTGCGGACCTTGCCTATGAGCGCAGCGA
TATCGAACTGGAAATTGAGCGCGTCGGTGACGAAATCCGCATTCGGCCGATGCGGCGGCCTTTGACTCAGGTACTGGCGA
AGTTCGCGAAATTCGGGCCGGACTTCATGGCCGATGGGCGTGGCGACCACGAGCAGGCCGAACGCGAGGGTTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A364GQ02

Antitoxin

Source ID Structure
AlphaFold DB A0A364GPY9

References