Detailed information of TA system TA047021

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 50670..51204
• Replicon: chromosome
• Accession: NZ_CP007787
• Organism: Burkholderia cepacia strain DDS 7H-2

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: DM42_RS19520
• Protein ID: WP_021033200.1
• Coordinates: 50670..50969 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: DM42_RS19525
• Protein ID: WP_021033199.1
• Coordinates: 50959..51204 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DM42_RS19500	47511..48260	+	750	WP_034201945.1	uroporphyrinogen-III C-methyltransferase	-
DM42_RS19505	48260..48634	+	375	WP_012492609.1	cobalamin biosynthesis protein	-
DM42_RS19510	48670..49272	+	603	WP_006476035.1	cob(I)yrinic acid a,c-diamide adenosyltransferase	-
DM42_RS19515	49275..50579	+	1305	WP_034201790.1	cobyrinate a,c-diamide synthase	-
DM42_RS19520	50670..50969	-	300	WP_021033200.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DM42_RS19525	50959..51204	-	246	WP_021033199.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
DM42_RS19530	51319..52482	-	1164	WP_034201791.1	amidohydrolase	-
DM42_RS19535	52640..53656	-	1017	WP_034201946.1	acetyltransferase	-
DM42_RS19540	53656..54495	-	840	WP_034201792.1	N(5)-hydroxyornithine transformylase PvdF	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-94)

Antitoxin

• Antitoxin ParD (1-78)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11720.37 Da
• Isoelectric Point: 6.9677

>T47021 WP_021033200.1 NZ_CP007787:c50969-50670 [Burkholderia cepacia]
MAVKGRQLRLTPLAECDLEDIWRYTAEHWSPEQAEHYYRDLIGTMEALARGKKAGRICVVRDGYFRYPAGSHVVFYRETD
ETIDVIRVLHQRMDIERHL

Nucleotide

• Length: 300 bp

>T47021 NZ_CP007787:c50969-50670 [Burkholderia cepacia]
ATGGCGGTTAAAGGCAGACAACTTCGGCTGACCCCGTTGGCTGAATGCGATCTTGAAGACATTTGGCGCTATACCGCCGA
GCATTGGTCGCCTGAGCAGGCAGAGCACTATTACCGCGATCTGATTGGCACCATGGAAGCGCTGGCGCGCGGCAAAAAAG
CGGGGCGGATTTGCGTTGTTCGCGACGGATATTTTCGCTACCCCGCTGGTTCTCACGTTGTGTTCTATCGCGAAACGGAT
GAAACCATCGACGTCATCCGTGTCCTGCATCAACGGATGGACATCGAACGACATCTGTAG

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8708.68 Da
• Isoelectric Point: 7.3196

>AT47021 WP_021033199.1 NZ_CP007787:c51204-50959 [Burkholderia cepacia]
MSRNTSVSLGDHFAEFVDAQVRSGRYGSASDVVRAGLRLLESHETQMRALQEALKAGEGSGTPKPFDSEAFLARMRATHG
G

Nucleotide

• Length: 246 bp

>AT47021 NZ_CP007787:c51204-50959 [Burkholderia cepacia]
ATGTCGCGAAACACATCCGTTTCCCTTGGCGATCACTTTGCAGAATTTGTCGATGCGCAGGTGCGATCGGGACGATATGG
TTCCGCAAGTGACGTCGTGCGAGCCGGGTTGCGGCTCCTCGAATCACACGAAACGCAAATGCGTGCATTGCAGGAAGCAT
TGAAGGCGGGTGAAGGGTCGGGGACGCCCAAGCCCTTCGACAGCGAGGCCTTCCTGGCCCGCATGCGGGCCACGCATGGC
GGTTAA