Detailed information of TA system TA047020

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 3135725..3136364
• Replicon: chromosome
• Accession: NZ_CP007786
• Organism: Burkholderia cepacia strain DDS 7H-2

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: DM42_RS18945
• Protein ID: WP_171984041.1
• Coordinates: 3135948..3136364 (+)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A364H554
• Locus tag: DM42_RS18940
• Protein ID: WP_006481537.1
• Coordinates: 3135725..3135961 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DM42_RS18925	3131896..3132669	+	774	WP_034202282.1	SDR family oxidoreductase	-
DM42_RS18930	3133318..3133995	+	678	WP_077176171.1	hypothetical protein	-
DM42_RS18935	3134006..3135232	-	1227	WP_034202283.1	acyltransferase	-
DM42_RS18940	3135725..3135961	+	237	WP_006481537.1	DNA-binding protein	Antitoxin
DM42_RS18945	3135948..3136364	+	417	WP_171984041.1	type II toxin-antitoxin system VapC family toxin	Toxin
DM42_RS18950	3136624..3137520	+	897	WP_034202285.1	VOC family protein	-
DM42_RS18955	3137530..3138423	+	894	WP_034202286.1	CoA transferase subunit A	-
DM42_RS18960	3138434..3139231	+	798	WP_006481539.1	hypothetical protein	-
DM42_RS18965	3139240..3140160	+	921	WP_006481536.1	enoyl-CoA hydratase	-
DM42_RS18970	3140157..3141257	+	1101	WP_034202287.1	nitronate monooxygenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-130)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 15388.61 Da
• Isoelectric Point: 6.8818

>T47020 WP_171984041.1 NZ_CP007786:3135948-3136364 [Burkholderia cepacia]
VFLIDTNVISEIRKGKRTNRGVRAFFRQAEADASPLYLSVVTVAELRRGVDLIRHRGDHSQASALEAWLSMILSGYAPNI
LPVDVETGQMWGHLRVPDPTHELDKLIAATALINDLTVVTRNVDDFARTGVRLLNPFE

Nucleotide

• Length: 417 bp

>T47020 NZ_CP007786:3135948-3136364 [Burkholderia cepacia]
GTGTTTTTGATTGATACGAACGTCATCAGCGAAATCAGGAAGGGCAAGCGAACCAACCGCGGCGTGCGGGCGTTCTTCAG
GCAGGCCGAAGCCGACGCGAGCCCGCTTTACCTGTCCGTCGTGACGGTGGCCGAGCTGCGGCGCGGTGTCGACCTGATCC
GTCATCGCGGCGATCACAGCCAGGCGTCGGCGCTCGAGGCTTGGCTGTCGATGATCCTGTCCGGCTATGCGCCGAACATC
CTGCCGGTCGATGTCGAAACCGGCCAGATGTGGGGGCATTTGCGCGTGCCCGATCCGACGCACGAACTCGACAAGCTGAT
CGCGGCCACCGCATTGATCAACGATTTGACGGTCGTCACGCGCAACGTCGACGATTTCGCTCGCACCGGCGTCCGGTTGC
TGAATCCGTTCGAGTAA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8710.78 Da
• Isoelectric Point: 5.0916

>AT47020 WP_006481537.1 NZ_CP007786:3135725-3135961 [Burkholderia cepacia]
MANLLVRNVDDTLVQSLREQAAANGRSAEAEHRAILAEALGRPKRRTFAQVLMSMPEVGEDADFQRVQDSGEVRRVFD

Nucleotide

• Length: 237 bp

>AT47020 NZ_CP007786:3135725-3135961 [Burkholderia cepacia]
ATGGCAAATCTTCTGGTGCGTAACGTGGATGACACTCTCGTTCAAAGCCTGCGCGAGCAGGCTGCGGCCAACGGCAGGAG
CGCCGAGGCCGAACATCGAGCCATTCTGGCCGAGGCGCTCGGCCGGCCGAAGCGGCGCACATTCGCGCAAGTGCTGATGA
GCATGCCGGAGGTGGGCGAAGACGCGGATTTCCAACGTGTTCAGGATTCAGGCGAGGTCAGGCGTGTTTTTGATTGA

Structures

Antitoxin

• AlphaFold DB: A0A364H554