Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC-StbC |
Location | 3135725..3136364 | Replicon | chromosome |
Accession | NZ_CP007786 | ||
Organism | Burkholderia cepacia strain DDS 7H-2 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | - |
Locus tag | DM42_RS18945 | Protein ID | WP_171984041.1 |
Coordinates | 3135948..3136364 (+) | Length | 139 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | A0A364H554 |
Locus tag | DM42_RS18940 | Protein ID | WP_006481537.1 |
Coordinates | 3135725..3135961 (+) | Length | 79 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
DM42_RS18925 | 3131896..3132669 | + | 774 | WP_034202282.1 | SDR family oxidoreductase | - |
DM42_RS18930 | 3133318..3133995 | + | 678 | WP_077176171.1 | hypothetical protein | - |
DM42_RS18935 | 3134006..3135232 | - | 1227 | WP_034202283.1 | acyltransferase | - |
DM42_RS18940 | 3135725..3135961 | + | 237 | WP_006481537.1 | DNA-binding protein | Antitoxin |
DM42_RS18945 | 3135948..3136364 | + | 417 | WP_171984041.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
DM42_RS18950 | 3136624..3137520 | + | 897 | WP_034202285.1 | VOC family protein | - |
DM42_RS18955 | 3137530..3138423 | + | 894 | WP_034202286.1 | CoA transferase subunit A | - |
DM42_RS18960 | 3138434..3139231 | + | 798 | WP_006481539.1 | hypothetical protein | - |
DM42_RS18965 | 3139240..3140160 | + | 921 | WP_006481536.1 | enoyl-CoA hydratase | - |
DM42_RS18970 | 3140157..3141257 | + | 1101 | WP_034202287.1 | nitronate monooxygenase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 15388.61 Da Isoelectric Point: 6.8818
>T47020 WP_171984041.1 NZ_CP007786:3135948-3136364 [Burkholderia cepacia]
VFLIDTNVISEIRKGKRTNRGVRAFFRQAEADASPLYLSVVTVAELRRGVDLIRHRGDHSQASALEAWLSMILSGYAPNI
LPVDVETGQMWGHLRVPDPTHELDKLIAATALINDLTVVTRNVDDFARTGVRLLNPFE
VFLIDTNVISEIRKGKRTNRGVRAFFRQAEADASPLYLSVVTVAELRRGVDLIRHRGDHSQASALEAWLSMILSGYAPNI
LPVDVETGQMWGHLRVPDPTHELDKLIAATALINDLTVVTRNVDDFARTGVRLLNPFE
Download Length: 417 bp
>T47020 NZ_CP007786:3135948-3136364 [Burkholderia cepacia]
GTGTTTTTGATTGATACGAACGTCATCAGCGAAATCAGGAAGGGCAAGCGAACCAACCGCGGCGTGCGGGCGTTCTTCAG
GCAGGCCGAAGCCGACGCGAGCCCGCTTTACCTGTCCGTCGTGACGGTGGCCGAGCTGCGGCGCGGTGTCGACCTGATCC
GTCATCGCGGCGATCACAGCCAGGCGTCGGCGCTCGAGGCTTGGCTGTCGATGATCCTGTCCGGCTATGCGCCGAACATC
CTGCCGGTCGATGTCGAAACCGGCCAGATGTGGGGGCATTTGCGCGTGCCCGATCCGACGCACGAACTCGACAAGCTGAT
CGCGGCCACCGCATTGATCAACGATTTGACGGTCGTCACGCGCAACGTCGACGATTTCGCTCGCACCGGCGTCCGGTTGC
TGAATCCGTTCGAGTAA
GTGTTTTTGATTGATACGAACGTCATCAGCGAAATCAGGAAGGGCAAGCGAACCAACCGCGGCGTGCGGGCGTTCTTCAG
GCAGGCCGAAGCCGACGCGAGCCCGCTTTACCTGTCCGTCGTGACGGTGGCCGAGCTGCGGCGCGGTGTCGACCTGATCC
GTCATCGCGGCGATCACAGCCAGGCGTCGGCGCTCGAGGCTTGGCTGTCGATGATCCTGTCCGGCTATGCGCCGAACATC
CTGCCGGTCGATGTCGAAACCGGCCAGATGTGGGGGCATTTGCGCGTGCCCGATCCGACGCACGAACTCGACAAGCTGAT
CGCGGCCACCGCATTGATCAACGATTTGACGGTCGTCACGCGCAACGTCGACGATTTCGCTCGCACCGGCGTCCGGTTGC
TGAATCCGTTCGAGTAA
Antitoxin
Download Length: 79 a.a. Molecular weight: 8710.78 Da Isoelectric Point: 5.0916
>AT47020 WP_006481537.1 NZ_CP007786:3135725-3135961 [Burkholderia cepacia]
MANLLVRNVDDTLVQSLREQAAANGRSAEAEHRAILAEALGRPKRRTFAQVLMSMPEVGEDADFQRVQDSGEVRRVFD
MANLLVRNVDDTLVQSLREQAAANGRSAEAEHRAILAEALGRPKRRTFAQVLMSMPEVGEDADFQRVQDSGEVRRVFD
Download Length: 237 bp
>AT47020 NZ_CP007786:3135725-3135961 [Burkholderia cepacia]
ATGGCAAATCTTCTGGTGCGTAACGTGGATGACACTCTCGTTCAAAGCCTGCGCGAGCAGGCTGCGGCCAACGGCAGGAG
CGCCGAGGCCGAACATCGAGCCATTCTGGCCGAGGCGCTCGGCCGGCCGAAGCGGCGCACATTCGCGCAAGTGCTGATGA
GCATGCCGGAGGTGGGCGAAGACGCGGATTTCCAACGTGTTCAGGATTCAGGCGAGGTCAGGCGTGTTTTTGATTGA
ATGGCAAATCTTCTGGTGCGTAACGTGGATGACACTCTCGTTCAAAGCCTGCGCGAGCAGGCTGCGGCCAACGGCAGGAG
CGCCGAGGCCGAACATCGAGCCATTCTGGCCGAGGCGCTCGGCCGGCCGAAGCGGCGCACATTCGCGCAAGTGCTGATGA
GCATGCCGGAGGTGGGCGAAGACGCGGATTTCCAACGTGTTCAGGATTCAGGCGAGGTCAGGCGTGTTTTTGATTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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