Detailed information of TA system TA047018

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 2538963..2540189
• Replicon: chromosome
• Accession: NZ_CP007786
• Organism: Burkholderia cepacia strain DDS 7H-2

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: DM42_RS16425
• Protein ID: WP_034202038.1
• Coordinates: 2538963..2539544 (-)
• Length: 194 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: DM42_RS16430
• Protein ID: WP_006483170.1
• Coordinates: 2539623..2540189 (-)
• Length: 189 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DM42_RS16410	2534687..2536720	-	2034	WP_034202037.1	MacB family efflux pump subunit	-
DM42_RS16415	2536723..2537907	-	1185	WP_034203312.1	macrolide transporter subunit MacA	-
DM42_RS16420	2538179..2538907	-	729	WP_006483165.1	class I SAM-dependent methyltransferase	-
DM42_RS16425	2538963..2539544	-	582	WP_034202038.1	HD domain-containing protein	Toxin
DM42_RS16430	2539623..2540189	-	567	WP_006483170.1	helix-turn-helix domain-containing protein	Antitoxin
DM42_RS16435	2540636..2542039	+	1404	WP_034202039.1	hypothetical protein	-
DM42_RS16440	2542133..2542705	+	573	WP_034202040.1	hypothetical protein	-
DM42_RS16445	2542784..2543173	-	390	WP_006498850.1	OsmC family protein	-
DM42_RS16450	2543404..2544135	+	732	WP_034202041.1	ribonuclease T2	-
DM42_RS16455	2544161..2544796	-	636	WP_034202042.1	cysteine hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• 5'-deoxynucleotidase YfbR/HDDC2 (6-146)

Antitoxin

• Cro/C1-type helix-turn-helix domain (12-64)

Sequences

Toxin

Protein

• Length: 194 a.a.
• Molecular weight: 21310.91 Da
• Isoelectric Point: 4.9572

>T47018 WP_034202038.1 NZ_CP007786:c2539544-2538963 [Burkholderia cepacia]
MNPDTIRARLDFLRDAERLKDVLRSGHTSAGRAESTAEHSWRLCLMALVFADALPGVDTLKLLKLCVVHDLGEALHGDIP
AIEQAAHPDKSVHERDDLLTLTASLDRAARDEIVALWDEYEAAASPEARAAKALDKLETILQHNQGSNPPDFDYAFNLGY
GRRYTDAAPLFSAIREIVDVDTQRRIDAGGQRA

Nucleotide

• Length: 582 bp

>T47018 NZ_CP007786:c2539544-2538963 [Burkholderia cepacia]
ATGAATCCCGATACGATCCGCGCGCGCCTCGATTTCCTGCGCGACGCCGAACGCCTGAAGGACGTGCTGCGCAGCGGCCA
CACGTCGGCCGGGCGCGCGGAAAGCACGGCCGAGCATAGCTGGCGGCTGTGCCTGATGGCGCTCGTGTTCGCCGACGCGC
TGCCCGGCGTCGATACGCTGAAGCTGCTGAAACTGTGCGTCGTCCACGACCTCGGCGAGGCGCTGCACGGCGACATCCCC
GCGATCGAGCAGGCCGCGCACCCCGACAAGAGCGTGCACGAACGCGACGACCTGCTGACGCTGACCGCGTCGCTCGACCG
CGCGGCGCGCGACGAGATCGTCGCGCTGTGGGACGAATACGAGGCGGCCGCCTCGCCGGAAGCCCGCGCGGCGAAAGCGC
TCGACAAGCTCGAAACGATCCTGCAGCACAACCAGGGCAGCAATCCGCCCGATTTCGACTATGCGTTCAATCTCGGCTAC
GGCCGGCGCTATACCGACGCCGCGCCGCTGTTCAGCGCGATCCGCGAGATCGTCGATGTCGACACGCAGCGCAGGATCGA
CGCGGGTGGGCAGCGCGCGTAA

Antitoxin

Protein

• Length: 189 a.a.
• Molecular weight: 20583.56 Da
• Isoelectric Point: 10.7753

>AT47018 WP_006483170.1 NZ_CP007786:c2540189-2539623 [Burkholderia cepacia]
MPHPPLHPSSLGPQLKRWRALHRVKQSHAAELFRVAQSTISRWEAGLQQMSPAERATAERLLAARLDSAGDHALARLIAG
STGRMHLVCDLTHRLLASSPARAAEFSRPLSTLLGASLWRYATPEIARMEAALDPLGWYDRAGPPSVEFDTGANASRVVP
IRGSLCRWTRMTLSDGSAVRLVETLDAH

Nucleotide

• Length: 567 bp

>AT47018 NZ_CP007786:c2540189-2539623 [Burkholderia cepacia]
ATGCCCCACCCGCCGCTTCATCCATCCTCGCTCGGCCCGCAACTCAAGCGCTGGCGCGCGCTGCACCGCGTAAAGCAAAG
CCATGCAGCCGAACTGTTCCGCGTCGCGCAATCGACGATCTCCCGCTGGGAAGCCGGCCTTCAGCAGATGTCGCCCGCCG
AGCGCGCGACGGCCGAACGGCTGCTCGCCGCGCGCCTCGATTCCGCGGGCGACCACGCGCTCGCGCGGCTGATCGCCGGC
AGCACGGGCCGCATGCATCTCGTGTGCGACCTCACGCACCGCCTGCTGGCCAGCTCGCCGGCGCGCGCGGCCGAGTTCTC
GCGGCCGCTTTCGACGCTGCTCGGCGCGTCGCTGTGGCGCTATGCGACGCCGGAAATCGCCCGCATGGAAGCCGCGCTCG
ACCCGCTCGGCTGGTACGACCGCGCGGGACCGCCGAGCGTCGAGTTCGATACCGGCGCGAACGCGTCGCGCGTCGTGCCG
ATTCGCGGCAGCCTGTGCCGATGGACGCGGATGACGCTGTCGGACGGCTCGGCCGTGCGGCTCGTGGAAACGCTGGACGC
GCACTGA