Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 862917..863537 Replicon chromosome
Accession NZ_CP007786
Organism Burkholderia cepacia strain DDS 7H-2

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag DM42_RS08805 Protein ID WP_144446004.1
Coordinates 862917..863234 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag DM42_RS08810 Protein ID WP_034202654.1
Coordinates 863238..863537 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DM42_RS08795 859426..860859 - 1434 WP_006490987.1 aldehyde dehydrogenase family protein -
DM42_RS08800 860888..862528 - 1641 WP_006490980.1 acetolactate synthase large subunit -
DM42_RS08805 862917..863234 + 318 WP_144446004.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DM42_RS08810 863238..863537 + 300 WP_034202654.1 putative addiction module antidote protein Antitoxin
DM42_RS08815 863586..864872 - 1287 WP_006490986.1 DUF445 domain-containing protein -
DM42_RS08820 864982..866202 - 1221 WP_034202655.1 FAD-dependent oxidoreductase -
DM42_RS08825 866192..866518 - 327 WP_006496019.1 non-heme iron oxygenase ferredoxin subunit -
DM42_RS08830 866554..867030 - 477 WP_006490977.1 aromatic-ring-hydroxylating dioxygenase subunit beta -
DM42_RS08835 867046..868317 - 1272 WP_006496020.1 Rieske 2Fe-2S domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(9-102)

Antitoxin

Uncharacterized protein HI1420

(4-97)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11841.52 Da        Isoelectric Point: 7.2769

>T47017 WP_144446004.1 NZ_CP007786:862917-863234 [Burkholderia cepacia]
MPYSPPAFSIRTTDVFDAWFAGLPDRLAKRRIQARIDRLSMGNPGDWKSAGSPVVEMRIDHGPGYRVYDVRRETIWVILL
CGGDQSTQQADIRAAHAMLAHLDME

Download         Length: 318 bp

>T47017 NZ_CP007786:862917-863234 [Burkholderia cepacia]
ATGCCCTACAGTCCTCCTGCATTCAGCATCCGGACCACCGACGTCTTCGACGCCTGGTTTGCCGGCCTGCCCGATCGCCT
CGCCAAACGCCGCATTCAGGCGCGCATCGACCGCCTGTCGATGGGCAATCCGGGCGACTGGAAATCCGCCGGCTCCCCCG
TCGTCGAAATGCGTATCGACCACGGCCCCGGCTATCGCGTCTATGACGTGAGGCGCGAAACGATATGGGTCATCCTGCTG
TGCGGCGGCGATCAATCGACGCAACAGGCCGACATCCGCGCCGCGCACGCAATGCTCGCGCACCTCGACATGGAGTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10644.12 Da        Isoelectric Point: 6.9774

>AT47017 WP_034202654.1 NZ_CP007786:863238-863537 [Burkholderia cepacia]
MDKIKTRPWDSAEHLKTEDDMADYFDACLQEAGDDPAFIAHALGVIARARGMSQVARHAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHAAKAAA

Download         Length: 300 bp

>AT47017 NZ_CP007786:863238-863537 [Burkholderia cepacia]
ATGGACAAGATCAAGACGCGGCCGTGGGATTCGGCCGAACACCTGAAAACCGAAGACGACATGGCCGACTACTTCGACGC
ATGCCTGCAGGAGGCCGGCGACGATCCGGCCTTCATCGCGCATGCGCTCGGCGTGATCGCCCGTGCACGCGGCATGTCGC
AGGTCGCGCGCCATGCGGGCCTGTCGCGCGAAGGGCTGTACAAGGCGCTGTCGCACGACGGCAATCCGAGCTTCGGCACG
ATCCTGAAAGTCATCAAGGCGCTCGGCCTGCAATTGCACGCCGCCAAGGCTGCCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References