Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 3184315..3184954 Replicon chromosome
Accession NZ_CP007784
Organism Burkholderia cenocepacia strain DDS 22E-1

Toxin (Protein)


Gene name vapC Uniprot ID A0A132F6A2
Locus tag DM39_RS35115 Protein ID WP_040131699.1
Coordinates 3184538..3184954 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A132F697
Locus tag DM39_RS35110 Protein ID WP_040131698.1
Coordinates 3184315..3184551 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DM39_RS35085 3179422..3180165 + 744 WP_040131694.1 GntR family transcriptional regulator -
DM39_RS35090 3180179..3181030 + 852 WP_040131695.1 sulfite exporter TauE/SafE family protein -
DM39_RS35095 3181027..3181350 + 324 WP_040131696.1 DUF1634 domain-containing protein -
DM39_RS35100 3182150..3182842 + 693 WP_080293159.1 hypothetical protein -
DM39_RS37520 3183000..3184154 - 1155 WP_144397932.1 hypothetical protein -
DM39_RS35110 3184315..3184551 + 237 WP_040131698.1 DNA-binding protein Antitoxin
DM39_RS35115 3184538..3184954 + 417 WP_040131699.1 type II toxin-antitoxin system VapC family toxin Toxin
DM39_RS35120 3185165..3186061 + 897 WP_040131700.1 VOC family protein -
DM39_RS35125 3186071..3186964 + 894 WP_040131701.1 CoA transferase subunit A -
DM39_RS35130 3186975..3187772 + 798 WP_040131702.1 ketoacid CoA transferase -
DM39_RS35135 3187781..3188719 + 939 WP_040131703.1 enoyl-CoA hydratase -
DM39_RS35140 3188716..3189804 + 1089 WP_040131704.1 nitronate monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15515.78 Da        Isoelectric Point: 9.7278

>T47015 WP_040131699.1 NZ_CP007784:3184538-3184954 [Burkholderia cenocepacia]
MYLIDTNVISETRKKTRANAGVLSFFRQARDNNDPLYLSIVTISELQRGVDLVRFRGDTKQAARLDAWLATIVQDHARHV
LTVDAEIAQLWGRLRVPQPDHALDKLIAATALIHDLTVVTRNVGDFARTGVKLLNPFD

Download         Length: 417 bp

>T47015 NZ_CP007784:3184538-3184954 [Burkholderia cenocepacia]
ATGTATTTGATTGACACGAACGTCATCAGCGAAACACGCAAGAAAACGCGCGCCAATGCCGGCGTGCTCTCGTTCTTCCG
ACAGGCGCGCGACAACAACGACCCGCTGTACCTGTCGATCGTGACGATTTCCGAGCTGCAGCGCGGCGTCGATCTCGTGC
GCTTTCGCGGCGATACGAAACAGGCGGCCCGGCTCGATGCATGGCTCGCGACGATCGTGCAGGACCACGCGCGCCATGTC
CTGACTGTCGACGCCGAAATCGCGCAGCTCTGGGGTCGCCTGCGCGTGCCGCAGCCCGACCACGCACTCGACAAGCTGAT
CGCCGCCACCGCGCTGATCCACGACCTGACGGTCGTCACCCGCAACGTCGGCGATTTCGCGCGAACCGGCGTGAAACTCC
TGAACCCGTTCGACTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8646.60 Da        Isoelectric Point: 5.5563

>AT47015 WP_040131698.1 NZ_CP007784:3184315-3184551 [Burkholderia cenocepacia]
MPDLLVRNVDKTIIQSLREQAAAHGRSAEAEHRAILADALHRPKRRSLAEVLASMPNVGEDADFERRDDSGEGSHVFD

Download         Length: 237 bp

>AT47015 NZ_CP007784:3184315-3184551 [Burkholderia cenocepacia]
ATGCCTGATCTTCTGGTGCGAAATGTAGACAAGACCATCATCCAGAGTCTGCGCGAGCAGGCCGCGGCGCATGGCCGCAG
CGCGGAAGCGGAGCATCGGGCCATTCTGGCCGACGCGCTGCACCGCCCGAAACGCAGAAGCCTGGCCGAGGTGCTGGCAA
GCATGCCGAACGTGGGCGAAGACGCCGATTTCGAGCGCCGGGACGATTCCGGCGAGGGTTCTCATGTATTTGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A132F6A2

Antitoxin

Source ID Structure
AlphaFold DB A0A132F697

References