Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 2142506..2143101 Replicon chromosome
Accession NZ_CP007784
Organism Burkholderia cenocepacia strain DDS 22E-1

Toxin (Protein)


Gene name chpB Uniprot ID A0A132EL24
Locus tag DM39_RS30615 Protein ID WP_009693107.1
Coordinates 2142506..2142856 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID B9B2F5
Locus tag DM39_RS30620 Protein ID WP_006397258.1
Coordinates 2142850..2143101 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DM39_RS30605 2137574..2140774 + 3201 WP_040130933.1 multidrug efflux RND transporter permease subunit CeoB -
DM39_RS30610 2140785..2142326 + 1542 WP_040130934.1 multidrug efflux transporter outer membrane subunit OpcM -
DM39_RS30615 2142506..2142856 - 351 WP_009693107.1 type II toxin-antitoxin system ChpB family toxin Toxin
DM39_RS30620 2142850..2143101 - 252 WP_006397258.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
DM39_RS30625 2143421..2144914 - 1494 WP_040130935.1 M81 family metallopeptidase -
DM39_RS30630 2145015..2146319 - 1305 WP_040130936.1 MFS transporter -
DM39_RS30635 2146461..2147432 + 972 WP_009695446.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12414.43 Da        Isoelectric Point: 8.8909

>T47012 WP_009693107.1 NZ_CP007784:c2142856-2142506 [Burkholderia cenocepacia]
MVKRVKFERGDIVRVSLNPTLGREQQGDFRPALVLSPAAFNALGVALVAPITQGGEFARFAGFAVPLSGAGTETQGVALV
NMVRMLDLEARGARKVERAPVEVVEDALARLQTIIE

Download         Length: 351 bp

>T47012 NZ_CP007784:c2142856-2142506 [Burkholderia cenocepacia]
ATGGTGAAGCGCGTCAAGTTCGAGCGAGGCGATATCGTGCGCGTGAGCCTGAATCCGACTCTCGGTCGTGAGCAGCAGGG
CGACTTTCGTCCGGCGCTGGTGCTCTCCCCGGCAGCGTTCAACGCTTTGGGCGTTGCGCTGGTCGCACCGATCACCCAGG
GTGGCGAATTTGCCCGGTTCGCAGGGTTCGCGGTCCCGCTGTCCGGTGCAGGAACCGAGACGCAGGGCGTCGCACTGGTG
AACATGGTTCGCATGCTCGACCTGGAGGCGCGCGGCGCTCGCAAGGTCGAACGCGCGCCTGTCGAGGTCGTGGAAGATGC
ACTCGCCCGGCTTCAGACGATCATCGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9007.36 Da        Isoelectric Point: 6.2420

>AT47012 WP_006397258.1 NZ_CP007784:c2143101-2142850 [Burkholderia cenocepacia]
MELKIQKWGNSAAVRLPSVLLEQINATVGSSLSADVRPDGVLLTPARRKYSLDDLVAQCDTKAPFPADMAAWGEVKPVGR
EAW

Download         Length: 252 bp

>AT47012 NZ_CP007784:c2143101-2142850 [Burkholderia cenocepacia]
ATGGAACTCAAGATTCAAAAATGGGGCAATAGCGCGGCGGTTCGTTTGCCCAGCGTTCTGCTCGAACAGATCAATGCGAC
GGTCGGCAGTTCGCTGAGCGCGGACGTGCGCCCGGATGGCGTGTTGTTGACGCCGGCCCGCCGCAAGTATTCGCTCGATG
ATCTCGTTGCCCAATGCGACACGAAAGCGCCTTTCCCTGCCGACATGGCTGCATGGGGCGAGGTCAAGCCGGTGGGGCGT
GAGGCATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A132EL24

Antitoxin

Source ID Structure
AlphaFold DB A0A132EKI4

References