Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 1132660..1133307 Replicon chromosome
Accession NZ_CP007784
Organism Burkholderia cenocepacia strain DDS 22E-1

Toxin (Protein)


Gene name relE Uniprot ID A0A088UBP1
Locus tag DM39_RS26045 Protein ID WP_040130286.1
Coordinates 1132660..1133004 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A132EUP1
Locus tag DM39_RS26050 Protein ID WP_009692881.1
Coordinates 1133008..1133307 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DM39_RS26035 1129162..1130595 - 1434 WP_040130284.1 aldehyde dehydrogenase family protein -
DM39_RS26040 1130624..1132264 - 1641 WP_040130285.1 acetolactate synthase large subunit -
DM39_RS26045 1132660..1133004 + 345 WP_040130286.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DM39_RS26050 1133008..1133307 + 300 WP_009692881.1 putative addiction module antidote protein Antitoxin
DM39_RS26055 1133347..1134633 - 1287 WP_040130287.1 DUF445 domain-containing protein -
DM39_RS26060 1134952..1135692 + 741 WP_052102342.1 IclR family transcriptional regulator -
DM39_RS26065 1135859..1137409 + 1551 WP_144397939.1 OPT/YSL family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(16-109)

Antitoxin

Uncharacterized protein HI1420

(5-93)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13093.90 Da        Isoelectric Point: 8.8567

>T47009 WP_040130286.1 NZ_CP007784:1132660-1133004 [Burkholderia cenocepacia]
MVYIPTTTRYTPPIYSIRTTDVFDAWFDALQDRVAKRRIQARIDRLSMGNPGDWKSAGAPVVEMRIDHGSGYRVYYTRRE
SIWVILLCGGDKSTQRADIRAAHAMLAHLDFDTE

Download         Length: 345 bp

>T47009 NZ_CP007784:1132660-1133004 [Burkholderia cenocepacia]
ATGGTTTACATACCGACGACAACACGCTACACTCCGCCCATCTACAGCATTCGCACCACCGACGTGTTCGACGCGTGGTT
CGACGCGCTGCAGGACCGCGTCGCGAAACGCCGCATTCAGGCGCGCATCGACCGGCTGTCGATGGGCAATCCGGGCGACT
GGAAATCCGCCGGCGCGCCGGTCGTCGAAATGCGGATCGACCACGGCTCCGGCTACCGCGTCTACTACACGCGACGGGAG
TCGATCTGGGTGATCCTGCTTTGCGGCGGCGACAAGTCGACGCAACGGGCGGACATCCGCGCCGCGCACGCGATGCTCGC
GCATCTCGATTTCGATACGGAGTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10690.10 Da        Isoelectric Point: 6.6384

>AT47009 WP_009692881.1 NZ_CP007784:1133008-1133307 [Burkholderia cenocepacia]
MDKIKTRPWDSAEHLKTEDDMADYFDACLQEAGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGSKAHA

Download         Length: 300 bp

>AT47009 NZ_CP007784:1133008-1133307 [Burkholderia cenocepacia]
ATGGACAAGATCAAGACCCGGCCCTGGGATTCGGCCGAACACCTGAAAACCGAAGACGACATGGCCGATTATTTCGACGC
CTGTCTGCAGGAAGCCGGCGACGATCCGGCGTTCATCGCGCATGCGCTCGGCGTGATCGCGCGCGCGCGCGGCATGTCGC
AGGTCGCGCGCGATGCGGGCCTGTCGCGCGAAGGGCTGTACAAGGCGCTGTCGCACGACGGCAACCCGAGCTTCGGCACG
ATCCTGAAGGTCATCAAGGCGCTCGGCCTGCAGCTGCACGGCTCGAAAGCACACGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A088UBP1

Antitoxin

Source ID Structure
AlphaFold DB A0A132EUP1

References