Detailed information of TA system TA047007

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/Tad-HTH_37
• Location: 2672232..2672932
• Replicon: chromosome
• Accession: NZ_CP007783
• Organism: Burkholderia cenocepacia strain DDS 22E-1

Toxin (Protein)

• Gene name: tad
• Uniprot ID: -
• Locus tag: DM39_RS16710
• Protein ID: WP_040127915.1
• Coordinates: 2672232..2672609 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: A0A132EQT4
• Locus tag: DM39_RS16715
• Protein ID: WP_009688335.1
• Coordinates: 2672609..2672932 (+)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DM39_RS16685	2667936..2668391	+	456	WP_040127911.1	VOC family protein	-
DM39_RS16690	2668459..2670009	-	1551	WP_040127912.1	sodium:solute symporter family protein	-
DM39_RS16695	2670006..2670248	-	243	WP_009688332.1	DUF3311 domain-containing protein	-
DM39_RS16700	2670448..2671365	-	918	WP_040127913.1	spermidine synthase	-
DM39_RS16705	2671655..2671909	+	255	WP_040127914.1	hypothetical protein	-
DM39_RS16710	2672232..2672609	+	378	WP_040127915.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DM39_RS16715	2672609..2672932	+	324	WP_009688335.1	helix-turn-helix domain-containing protein	Antitoxin
DM39_RS16720	2672955..2673446	-	492	WP_040127916.1	DNA-deoxyinosine glycosylase	-
DM39_RS16725	2673443..2674057	-	615	WP_040128972.1	chorismate lyase	-
DM39_RS16730	2674066..2675964	-	1899	WP_040127917.1	molecular chaperone HtpG	-
DM39_RS16735	2676115..2677575	-	1461	WP_040127918.1	PLP-dependent aminotransferase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (22-115)

Antitoxin

• Cro/C1-type helix-turn-helix domain (30-85)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13766.80 Da
• Isoelectric Point: 9.9130

>T47007 WP_040127915.1 NZ_CP007783:2672232-2672609 [Burkholderia cenocepacia]
MGINSSMAPYTKRLYWLGSARKDLKAMPEAVQDTFGYALYLAQTGRKHDQAKPLRGFGSAGVLEVVESEDNGTYRAVYTV
KLGSAVYVLHCFQKKSSRGIATPKPDVDLVRERLKAAEAHAMGEK

Nucleotide

• Length: 378 bp

>T47007 NZ_CP007783:2672232-2672609 [Burkholderia cenocepacia]
ATGGGTATAAATTCATCGATGGCTCCGTACACCAAACGGCTCTACTGGCTCGGCTCGGCACGCAAGGATTTGAAAGCGAT
GCCCGAAGCGGTGCAGGACACGTTCGGCTACGCGCTGTATCTGGCCCAGACGGGAAGAAAGCACGATCAGGCCAAACCGT
TGAGGGGCTTTGGATCGGCCGGCGTGCTCGAGGTCGTGGAGTCGGAGGACAACGGCACGTATCGTGCCGTCTATACGGTG
AAACTGGGTAGCGCCGTCTATGTGCTGCACTGCTTTCAGAAGAAATCGTCGCGCGGTATCGCTACGCCGAAGCCGGACGT
CGATCTGGTTCGCGAGCGTCTGAAAGCAGCCGAAGCACACGCAATGGGAGAAAAGTGA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 11749.69 Da
• Isoelectric Point: 7.2791

>AT47007 WP_009688335.1 NZ_CP007783:2672609-2672932 [Burkholderia cenocepacia]
MIEIEPGSGNVYADLGMPDAEEMRVKAQLAAKIAEIIKARKWTQQHAARLLGMTQPKLSNMLRGQFRGVSEAKMLDCLAK
LGRDVQIVVGPDRHPEAEGHIEVVFAA

Nucleotide

• Length: 324 bp

>AT47007 NZ_CP007783:2672609-2672932 [Burkholderia cenocepacia]
ATGATCGAAATCGAACCGGGCAGCGGCAACGTCTACGCGGACCTCGGCATGCCCGATGCCGAAGAAATGCGCGTGAAGGC
TCAACTCGCCGCCAAGATCGCGGAGATCATCAAGGCGCGGAAATGGACGCAGCAGCACGCGGCCCGGTTGCTCGGCATGA
CGCAACCCAAGCTATCGAACATGCTGCGCGGGCAGTTTCGCGGCGTGAGCGAAGCAAAGATGCTGGACTGTCTCGCCAAG
CTCGGGCGCGACGTACAGATCGTCGTGGGGCCGGACCGTCATCCAGAAGCCGAAGGACACATCGAAGTCGTGTTCGCTGC
CTGA

Structures

Antitoxin

• AlphaFold DB: A0A132EQT4