Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1755788..1756464 Replicon chromosome
Accession NZ_CP007783
Organism Burkholderia cenocepacia strain DDS 22E-1

Toxin (Protein)


Gene name vagD Uniprot ID A0A088U587
Locus tag DM39_RS12515 Protein ID WP_040127400.1
Coordinates 1756048..1756464 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A132ESV6
Locus tag DM39_RS12510 Protein ID WP_009694207.1
Coordinates 1755788..1756051 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DM39_RS12495 1751451..1753673 + 2223 WP_040128872.1 TonB-dependent siderophore receptor -
DM39_RS12500 1753732..1754571 + 840 WP_040127398.1 N(5)-hydroxyornithine transformylase PvdF -
DM39_RS12505 1754571..1755575 + 1005 WP_040127399.1 acetyltransferase -
DM39_RS12510 1755788..1756051 + 264 WP_009694207.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
DM39_RS12515 1756048..1756464 + 417 WP_040127400.1 PIN domain-containing protein Toxin
DM39_RS12520 1756495..1757400 - 906 WP_040127401.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
DM39_RS12525 1757369..1758436 - 1068 WP_040127402.1 hypothetical protein -
DM39_RS12530 1758749..1759912 + 1164 WP_040127403.1 amidohydrolase -
DM39_RS12535 1760047..1761390 - 1344 WP_052102229.1 cobyrinate a,c-diamide synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-130)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14765.99 Da        Isoelectric Point: 8.5393

>T47006 WP_040127400.1 NZ_CP007783:1756048-1756464 [Burkholderia cenocepacia]
VTALYMLDTNICSFIMRERPAAVLSRLQACVDAQHRIVVSAITYAEMRFGAIGRKASPKHADLVTAFVARLDGVLPWDTA
AIDATVTVRAALAARGTPIGANDASIAGHAIAAGAVLVTNNSREFRRVERLSFEDWAA

Download         Length: 417 bp

>T47006 NZ_CP007783:1756048-1756464 [Burkholderia cenocepacia]
GTGACCGCGCTCTACATGCTCGATACGAACATCTGCTCGTTCATCATGCGCGAGCGGCCGGCGGCGGTCCTGTCGCGGCT
GCAGGCGTGCGTCGATGCGCAGCACCGGATCGTCGTGTCGGCGATTACCTATGCGGAAATGCGGTTCGGCGCGATCGGCA
GGAAAGCGTCGCCGAAGCATGCGGATCTCGTCACGGCCTTCGTCGCGCGGCTGGACGGCGTGCTGCCGTGGGACACGGCG
GCCATCGATGCGACCGTCACCGTTCGCGCGGCGCTTGCCGCGCGCGGCACGCCGATCGGCGCGAACGACGCGTCGATTGC
CGGGCATGCGATCGCGGCCGGCGCGGTGCTCGTGACGAACAACAGTCGCGAATTCCGCCGGGTCGAGCGCTTGTCGTTCG
AGGATTGGGCGGCTTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9728.01 Da        Isoelectric Point: 4.5112

>AT47006 WP_009694207.1 NZ_CP007783:1755788-1756051 [Burkholderia cenocepacia]
MRTVSIFKNARNQAIRIPKDMEFEGVTELEIRREGDTLLLRPVRPTWMSLASEPLADADFLAERPAVVESGRFDLPGDDA
APTESGR

Download         Length: 264 bp

>AT47006 NZ_CP007783:1755788-1756051 [Burkholderia cenocepacia]
ATGCGTACCGTTTCCATTTTCAAGAACGCCCGTAACCAGGCGATCCGCATCCCGAAGGACATGGAATTCGAGGGGGTGAC
GGAACTCGAGATCCGCCGGGAGGGCGACACGCTGCTGTTGCGTCCGGTGCGTCCGACCTGGATGTCGCTCGCGAGCGAGC
CGCTGGCCGACGCCGACTTCCTCGCCGAACGTCCGGCCGTCGTCGAATCCGGCCGCTTCGACCTGCCCGGCGACGATGCC
GCGCCGACGGAGTCCGGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A088U587

Antitoxin

Source ID Structure
AlphaFold DB A0A132ESV6

References