Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-vagC/VapC-VagC
Location 36548..37185 Replicon chromosome
Accession NZ_CP007783
Organism Burkholderia cenocepacia strain DDS 22E-1

Toxin (Protein)


Gene name vapC Uniprot ID A0A088U2G3
Locus tag DM39_RS04760 Protein ID WP_009694331.1
Coordinates 36784..37185 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A132EWB1
Locus tag DM39_RS04755 Protein ID WP_006408845.1
Coordinates 36548..36784 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DM39_RS04735 31683..32225 + 543 WP_040128677.1 hypothetical protein -
DM39_RS04740 32442..33479 + 1038 WP_040128679.1 helix-turn-helix domain-containing protein -
DM39_RS04745 33555..34658 - 1104 WP_040126408.1 ADP-heptose--LPS heptosyltransferase -
DM39_RS04750 34655..36358 - 1704 WP_040126409.1 thiamine pyrophosphate-binding protein -
DM39_RS04755 36548..36784 + 237 WP_006408845.1 hypothetical protein Antitoxin
DM39_RS04760 36784..37185 + 402 WP_009694331.1 type II toxin-antitoxin system VapC family toxin Toxin
DM39_RS04765 37297..38685 - 1389 WP_040126410.1 L-serine ammonia-lyase -
DM39_RS04770 38716..39858 - 1143 WP_040128681.1 alginate lyase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14963.17 Da        Isoelectric Point: 5.7487

>T47004 WP_009694331.1 NZ_CP007783:36784-37185 [Burkholderia cenocepacia]
MPRYMLETNMCIYLMKNQPEQVARRFAQCYTGDVVMSAITYAELEYGVTVCANPARERRNLAALIEDIPVAPFDGAAAQA
YGPIREATRERKKDHLDKLIGAHAVSLDVVLVTNNERDFASYPGLRLENWLIG

Download         Length: 402 bp

>T47004 NZ_CP007783:36784-37185 [Burkholderia cenocepacia]
ATGCCGCGCTACATGCTCGAGACCAACATGTGCATCTATCTGATGAAGAACCAGCCGGAGCAGGTCGCGCGGCGTTTCGC
GCAGTGCTACACGGGGGACGTCGTCATGTCGGCGATCACCTATGCGGAACTCGAGTACGGCGTGACGGTATGTGCCAATC
CGGCCCGCGAACGCCGCAATCTCGCCGCGCTGATCGAGGATATCCCGGTTGCGCCGTTCGACGGAGCGGCTGCGCAGGCA
TACGGCCCCATTCGCGAGGCGACGCGGGAACGCAAGAAGGATCATCTCGACAAGCTGATCGGCGCGCACGCGGTATCGCT
CGACGTTGTGCTGGTGACCAACAACGAGCGTGATTTCGCGAGTTATCCGGGCTTGAGGCTCGAGAACTGGCTGATCGGCT
AG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8915.00 Da        Isoelectric Point: 5.8651

>AT47004 WP_006408845.1 NZ_CP007783:36548-36784 [Burkholderia cenocepacia]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERVGDEIRIRPARRPLTGVLGKFAKFGPDFMAEGRGDQEQAEREGW

Download         Length: 237 bp

>AT47004 NZ_CP007783:36548-36784 [Burkholderia cenocepacia]
ATGCATACCACCCGGGTCTTCCGGAATGGCAACTCGCAGGCGGTGCGGATTCCTGCGGATCTGGCTTATGAGCGCAGCGA
CATCGAACTCGAAATCGAGCGTGTCGGTGACGAAATTCGCATCCGGCCTGCGCGGCGGCCGCTGACCGGCGTGCTCGGCA
AGTTCGCGAAATTCGGGCCGGATTTCATGGCCGAGGGGCGAGGCGATCAGGAACAGGCCGAGCGCGAGGGCTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A088U2G3

Antitoxin

Source ID Structure
AlphaFold DB A0A132EWB1

References